Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy

scientific article published on 23 January 2016

Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/QAD.0000000000001029
P932PMC publication ID4889535
P698PubMed publication ID26807971

P50authorNicolas ChomontQ56909197
Steven G DeeksQ57425986
Gabriela KhouryQ63682046
Rémi FromentinQ89423811
Peter BacchettiQ89655223
Wendy HartogenesisQ114718150
Sharon R. LewinQ37618308
Miranda Z. SmithQ38359495
Frederick M. HechtQ45955550
P2093author name stringJenny L Anderson
Paul U Cameron
P2860cites workFollicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin productionQ24676570
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapyQ28544949
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapyQ29615992
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationQ29619611
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infectionQ29619738
Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cellsQ29622847
Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cureQ33593633
In vivo evidence for instability of episomal human immunodeficiency virus type 1 cDNA.Q33724206
Rapid turnover of 2-LTR HIV-1 DNA during early stage of highly active antiretroviral therapy.Q33936651
A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cellsQ34033414
HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoirQ34097573
Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton.Q34165677
Th17 cells are long lived and retain a stem cell-like molecular signatureQ34241261
Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapyQ34384134
Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapyQ34588169
STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells.Q53629028
Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapyQ73308229
Immune reconstitution in the sigmoid colon after long-term HIV therapyQ82949871
Cross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studiesQ34593784
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllersQ35058635
Peripheral blood CCR4+CCR6+ and CXCR3+CCR6+CD4+ T cells are highly permissive to HIV-1 infectionQ35064033
Expansion of HIV-specific T follicular helper cells in chronic HIV infectionQ36190755
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper functionQ36368291
Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cellsQ36399680
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and productionQ36547664
Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cellsQ36882465
The distribution of HIV DNA and RNA in cell subsets differs in gut and blood of HIV-positive patients on ART: implications for viral persistenceQ37187497
Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligandsQ37252952
Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replicationQ37504330
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissuesQ37587740
HIV-1 persistence in CD4+ T cells with stem cell-like propertiesQ37646541
HIV 2-long terminal repeat circular DNA is stable in primary CD4+T Cells.Q38711403
Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection.Q38984682
Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replicationQ39683177
Rules of chemokine receptor association with T cell polarization in vivoQ39947109
Polarized secretion of CXC chemokines by human intestinal epithelial cells in response to Bacteroides fragilis enterotoxin: NF-kappa B plays a major role in the regulation of IL-8 expressionQ40813378
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.Q42261388
The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut.Q43095069
Both CD31(+) and CD31⁻ naive CD4(+) T cells are persistent HIV type 1-infected reservoirs in individuals receiving antiretroviral therapyQ43941310
Human T cells that are able to produce IL-17 express the chemokine receptor CCR6.Q45054355
Relationship between the size of the human immunodeficiency virus type 1 (HIV-1) reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios in aviremic HIV-1-infected individuals receiving long-term highly active antiretroviral therapyQ45732447
Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitroQ46066602
Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.Q50638760
Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwards.Q51404609
Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell DifferentiationQ52005548
C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential.Q52022548
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectanti-retroviral agentQ50430310
P304page(s)1511-1520
P577publication date2016-01-23
P1433published inAIDSQ4651863
P1476titlePersistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4+ T cells in HIV-infected individuals on antiretroviral therapy
P478volume30

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