Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development

scientific article published on 06 June 2016

Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1026388905
P356DOI10.1038/SREP27273
P932PMC publication ID4893675
P698PubMed publication ID27265527

P50authorNicole J CamlinQ59509946
Eileen A. McLaughlinQ40566884
Jose M TeixeiraQ41678012
P2093author name stringManish Kumar
Pradeep S Tanwar
Janet E Holt
P2860cites workThe APC/C activator FZR1 is essential for meiotic prophase I in miceQ50687460
Bilateral Sertoli cell tumors of the testis-a likely new extracolonic manifestation of familial adenomatous polyposis.Q54325079
Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.Q54443542
Frequent Mutation and Nuclear Localization of β-Catenin in Sertoli Cell Tumors of the TestisQ58813259
Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cellsQ73473616
RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovaryQ21135138
Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergyQ24319025
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin geneQ24529898
Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTENQ27335766
Wnt/beta-catenin signaling in development and diseaseQ27860784
Female development in mammals is regulated by Wnt-4 signallingQ28507770
Mice null for Frizzled4 (Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and functionQ28584867
The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progressionQ28584889
Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinizationQ30431287
A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse.Q30497823
Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesisQ33601965
Wt1 negatively regulates beta-catenin signaling during testis developmentQ33684753
WNT4 is required for normal ovarian follicle development and female fertility.Q34017075
Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchymeQ34136372
β-catenin/Tcf-signaling appears to establish the murine ovarian surface epithelium (OSE) and remains active in selected postnatal OSE cellsQ34298272
Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.Q34390606
Adenomatous polyposis coli (APC) is essential for maintaining the integrity of the seminiferous epitheliumQ35238445
A fast and sensitive alternative for β-galactosidase detection in mouse embryos.Q36432913
The Müllerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained β-catenin signalingQ36435768
PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progressionQ36740722
Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression.Q36959003
Generation of a germ cell-specific mouse transgenic Cre line, Vasa-CreQ37001598
Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice.Q37318625
The mammalian ovary from genesis to revelationQ37385514
Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouseQ37404723
TCF/LEFs and Wnt signaling in the nucleus.Q38048246
Cre reporter mouse expressing a nuclear localized fusion of GFP and beta-galactosidase reveals new derivatives of Pax3-expressing precursorsQ42026011
β-Catenin/Tcf signaling in murine oocytes identifies nonovulatory folliclesQ44493687
Seminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in sertoli cellsQ46595570
Misregulated Wnt/beta-catenin signaling leads to ovarian granulosa cell tumor development.Q46757466
Analysis of regulatory elements of E-cadherin with reporter gene constructs in transgenic mouse embryosQ48303624
Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimüllerian hormone expression during oocyte maturation in the female follicle.Q48611818
The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development.Q48637468
The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytesQ48682522
Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryosQ48761731
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)27273
P577publication date2016-06-06
P1433published inScientific ReportsQ2261792
P1476titleGerm cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development
P478volume6

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cites work (P2860)
Q57471218CPEB2 Is Necessary for Proper Porcine Meiotic Maturation and Embryonic Development
Q89929937Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads
Q52564617Genome-Wide Association Analyses Highlight the Potential for Different Genetic Mechanisms for Litter Size Among Sheep Breeds.
Q37699112Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs.
Q90471369Investigating the role of BCAR4 in ovarian physiology and female fertility by genome editing in rabbit
Q92217820Synergistic inhibition of csal1 and csal3 in granulosa cell proliferation and steroidogenesis of hen ovarian prehierarchical development†
Q48274790Wnt signaling pathway regulates differentiation of chicken embryonic stem cells into spermatogonial stem cells via Wnt5a.

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