Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

scientific article published on November 2008

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.200805163
P932PMC publication ID2582891
P698PubMed publication ID19015317
P5875ResearchGate publication ID23479573

P50authorAvram HershkoQ232302
Tim J. YenQ30504251
P2093author name stringFrancesca Zappacosta
Roland S Annan
Haomin Huang
James Hittle
P2860cites workCharacterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1Q22003896
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APCQ22010522
A role for the Adenomatous Polyposis Coli protein in chromosome segregationQ24291074
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1Q24299555
Mitotic regulation of the human anaphase-promoting complex by phosphorylationQ24301075
Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachmentsQ24305012
Aurora B regulates MCAK at the mitotic centromereQ24307822
The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.Q24313445
The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinaseQ24314385
Mutations of mitotic checkpoint genes in human cancersQ24320018
Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochoresQ24555706
Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2Q24670095
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpointQ24675117
Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signalingQ24679267
Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.Q27939198
Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphaseQ28200158
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochoresQ28201606
Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometryQ28240553
Timing and checkpoints in the regulation of mitotic progressionQ28270657
Mammalian SGO2 appears at the inner centromere domain and redistributes depending on tension across centromeres during meiosis II and mitosisQ28513034
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activityQ30312108
Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/CQ30480589
Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamicsQ33340294
CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cellsQ33946743
Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.Q34101240
Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cellsQ34109497
Mad2 and BubR1 function in a single checkpoint pathway that responds to a loss of tension.Q34168724
The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosisQ34488826
Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors.Q34562965
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpointQ35690967
Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactionsQ35946386
Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cellsQ36118921
Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitopeQ36149262
CENP-E function at kinetochores is essential for chromosome alignment.Q36254954
BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1.Q36325139
Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complexQ36328322
CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpointQ38309596
BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignmentQ39746594
Cdk1 phosphorylation sites on Cdc27 are required for correct chromosomal localisation and APC/C function in syncytial Drosophila embryosQ40243297
Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.Q40724282
Drosophila BubR1 is essential for meiotic sister-chromatid cohesion and maintenance of synaptonemal complexQ42276140
Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1.Q45952803
Kin I kinesins are microtubule-destabilizing enzymesQ46042447
The mitotic checkpoint gene BubR1 has two distinct functions in mitosisQ46502073
Mad3/BubR1 phosphorylation during spindle checkpoint activation depends on both Polo and Aurora kinases in budding yeastQ46560518
Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1.Q51991100
Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint.Q52688239
CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay.Q53628325
Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore proteinQ72041271
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1Q79754843
The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachmentsQ81126953
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
kinetochoreQ908912
P304page(s)667-680
P577publication date2008-11-01
P1433published inJournal of Cell BiologyQ1524550
P1476titlePhosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit
P478volume183

Reverse relations

cites work (P2860)
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