CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study

scientific article published on 23 January 2013

CD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2012-10-461848
P932PMC publication ID3700465
P698PubMed publication ID23343832
P5875ResearchGate publication ID235366546

P50authorMichael Boe MøllerQ40448280
Karen DybkærQ41600604
Jane WinterQ43103944
Ronald S GoQ56990716
Attilio OraziQ57839894
Han van KriekenQ61840699
Kristy L RichardsQ86634383
Eric D. HsiQ87608965
Andrés J M FerreriQ88671445
Ken H YoungQ96348689
Zijun Y Xu-MonetteQ98718521
Maurilio PonzoniQ101383725
April ChiuQ110194439
William W L ChoiQ116791261
Alexander TzankovQ116791271
Aarthi BalasubramanyamQ116791277
Santiago Montes-MorenoQ37831466
Miguel A. PirisQ37831476
Roberto N. MirandaQ37842538
Govind BhagatQ38546986
Ganiraju ManyamQ39692890
P2093author name stringLi Zhang
Ling Li
Yong Li
Qin Huang
Lin Wu
L Jeffrey Medeiros
Youli Zu
Mingzhi Zhang
Carlo Visco
Jooryung Huh
Weiyun Ai
Xiaoying Zhao
Wei-min Liu
Shimin Hu
P2860cites workMolecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's diseaseQ24324634
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphomaQ24672476
CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cellsQ40177590
ALK+ lymphoma: clinico-pathological findings and outcome.Q40818386
Pleiotropic effects of the CD30 ligand on CD30-expressing cells and lymphoma cell lines.Q41474009
Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations.Q42277563
CD30+ lymphoproliferative disordersQ42415931
Immunoblastic morphology but not the immunohistochemical GCB/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL.Q42927053
The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: a bio-CORAL studyQ44875676
Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphomaQ46458342
Introduction of combined CHOP plus rituximab therapy dramatically improved outcome of diffuse large B-cell lymphoma in British ColumbiaQ46546765
Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: the British Columbia experienceQ46763721
LMO2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with anthracycline-based chemotherapy with and without rituximabQ46845332
Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.Q50495776
EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive post-germinal center B-cell neoplasm characterized by prominent nuclear factor-kB activation.Q51374652
CD30-CD30 ligand interaction in primary cutaneous CD30(+) T-cell lymphomas: A clue to the pathophysiology of clinical regression.Q52173273
Prognostic impact of immunohistochemically defined germinal center phenotype in diffuse large B-cell lymphoma patients treated with immunochemotherapy.Q53241753
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.Q53931762
Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient MiceQ57185434
Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cellsQ73281237
CD30 overexpression enhances negative selection in the thymus and mediates programmed cell death via a Bcl-2-sensitive pathwayQ77929168
High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosisQ79909002
Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signalingQ80422472
A phase I weekly dosing study of brentuximab vedotin in patients with relapsed/refractory CD30-positive hematologic malignanciesQ82489143
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphomaQ24680233
Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingQ27860529
Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarrayQ28204313
A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracyQ28256358
The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cellsQ28287097
Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphomaQ28290466
MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancersQ28306431
Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapyQ28307991
Safety and efficacy of brentuximab vedotin for Hodgkin lymphoma recurring after allogeneic stem cell transplantationQ33400803
Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: results of a phase II studyQ33401346
Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma.Q33669371
Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomasQ34147803
Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'AdulteQ34184706
Among diffuse large B-cell lymphomas, T-cell-rich/histiocyte-rich BCL and CD30+ anaplastic B-cell subtypes exhibit distinct clinical features.Q34325760
ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma ProjectQ34589970
Immunohistochemical methods for predicting cell of origin and survival in patients with diffuse large B-cell lymphoma treated with rituximabQ34679166
Cell of origin fails to predict survival in patients with diffuse large B-cell lymphoma treated with autologous hematopoietic stem cell transplantationQ35915899
Brentuximab vedotin enables successful reduced-intensity allogeneic hematopoietic cell transplantation in patients with relapsed or refractory Hodgkin lymphomaQ36058584
Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisoneQ36267666
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program StudyQ36395599
Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP ConQ36799606
Anaplastic Large Cell Lymphoma.Q36825791
Relation of CD30 expression to survival and morphology in large cell B cell lymphomasQ37245136
Double-hit B-cell lymphomasQ37813897
Anaplastic large-cell lymphomaQ37919489
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectdiffuse large B-cell lymphomaQ2626074
B-cell lymphomaQ4833719
P304page(s)2715-2724
P577publication date2013-01-23
P1433published inBloodQ885070
P1476titleCD30 expression defines a novel subgroup of diffuse large B-cell lymphoma with favorable prognosis and distinct gene expression signature: a report from the International DLBCL Rituximab-CHOP Consortium Program Study
P478volume121

Reverse relations

cites work (P2860)
Q89393373A B-cell-associated gene signature classification of diffuse large B-cell lymphoma by NanoString technology
Q50220287A treatment refractory CD30-positive diffuse large B cell lymphoma in the ileal neobladder
Q47912434Advances in systemic therapy for malignant mesothelioma: future perspectives
Q37697843Advances in the treatment of hematologic malignancies using immunoconjugates
Q40422243Brentuximab vedotin activity in diffuse large B-cell lymphoma with CD30 undetectable by visual assessment of conventional immunohistochemistry
Q35223221Brentuximab vedotin for relapsed or refractory Hodgkin's lymphoma
Q49282959Brentuximab vedotin: clinical updates and practical guidance
Q38466350CD 30-positive transformed follicular lymphoma: two case reports and literature review.
Q47416235CD30 Expression in Monomorphic Posttransplant Lymphoproliferative Disorder, Diffuse Large B-Cell Lymphoma Correlates With Greater Regulatory T-Cell Infiltration
Q38682195CD30 Expression in Pediatric Neoplasms, Study of 585 Cases
Q38950501CD30 and CD30-Targeted Therapies in Hodgkin Lymphoma and Other B cell Lymphomas
Q41411254CD30 expression and its correlation with MYC rearrangement in de novo diffuse large B-cell lymphoma
Q42199195CD30 expression in de novo diffuse large B-cell lymphoma: a population-based study from British Columbia
Q33655362CD30 expression in extranodal natural killer/T-cell lymphoma, nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China
Q23921491CD30 is a potential therapeutic target in malignant mesothelioma
Q35742367Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries.
Q48108703Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP.
Q89777688Clinicopathologic consensus study of gray zone lymphoma with features intermediate between DLBCL and classical HL
Q92120378Cluster of differentiation 30 expression in lacrimal gland and conjunctival tissues in patients with Sjögren's syndrome: Case series
Q58554680Combining Biology and Chemistry for a New Take on Chemotherapy: Antibody-Drug Conjugates in Hematologic Malignancies
Q92062001Complete Remission of Relapsed Hodgkin's Lymphoma following Brentuximab Vedotin and Gemcitabine Combination Therapy with Severe Hypotension as Possible Treatment-Related Adverse Event: A Case Report
Q55710335Different prevalence and clinical outcome of Epstein-Barr virus positive diffuse large B-cell lymphoma between North American and non-Western populations.
Q91690485Diffuse Large B-Cell Lymphoma in Kenya: MYC, BCL2, and the Cell of Origin
Q38710832Diffuse Large B-cell lymphoma: Prognostic markers and their impact on therapy
Q35419876Diffuse large B-cell lymphoma classification system that associates normal B-cell subset phenotypes with prognosis
Q36302961Does cell-of-origin or MYC, BCL2 or BCL6 translocation status provide prognostic information beyond the International Prognostic Index score in patients with diffuse large B-cell lymphoma treated with rituximab and chemotherapy? A systematic review
Q42051829EBV-negative monomorphic B-cell post-transplant lymphoproliferative disorders are pathologically distinct from EBV-positive cases and frequently contain TP53 mutations.
Q35723777Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma in the Elderly: A Matched Case-Control Analysis
Q35880791Epstein-Barr virus positive diffuse large B-cell lymphoma predict poor outcome, regardless of the age.
Q40796551Evaluation of NF-κB subunit expression and signaling pathway activation demonstrates that p52 expression confers better outcome in germinal center B-cell-like diffuse large B-cell lymphoma in association with CD30 and BCL2 functions
Q38947647Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms.
Q49789150Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma
Q64917080Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells.
Q41620612Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling
Q47584171Is CD30 a predictive biomarker for brentuximab vedotin?
Q92661439Molecular Complexity of Diffuse Large B-Cell Lymphoma: Can It Be a Roadmap for Precision Medicine?
Q58010774NFκB expression is a feature of both activated B-cell-like and germinal center B-cell-like subtypes of diffuse large B-cell lymphoma
Q38315779New therapies in non-Hodgkin lymphoma
Q38896683New uses for brentuximab vedotin and novel antibody drug conjugates in lymphoma
Q27304386Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review
Q30434521Nucleic Acid Aptamers as Potential Therapeutic and Diagnostic Agents for Lymphoma
Q41728703Occurrence and prognostic relevance of CD30 expression in post-transplant lymphoproliferative disorders.
Q57192334Oligonucleotide Aptamer-Mediated Precision Therapy of Hematological Malignancies
Q45324330Outcomes among US patients with diffuse large B cell lymphoma are independent of tumor Epstein Barr virus positivity or immunosuppression
Q91148601PD-1/PD-L1 expression and interaction by automated quantitative immunofluorescent analysis show adverse prognostic impact in patients with diffuse large B-cell lymphoma having T-cell infiltration: a study from the International DLBCL Consortium Prog
Q38245874Pathogenesis, diagnosis, and treatment of composite lymphomas
Q42230312Prevalence and clinical implications of cyclin D1 expression in diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program.
Q33583294Prevalence and clinical implications of epstein-barr virus infection in de novo diffuse large B-cell lymphoma in Western countries
Q36511738Prevalence and clinicopathologic features of CD30-positive de novo diffuse large B-cell lymphoma in Chinese patients: a retrospective study of 232 cases
Q41564189Primary CD30-positive Diffuse Large B-cell Lymphoma in the Superior Vena Cava
Q90014799Primary diffuse large B-cell lymphoma presenting as acute appendicitis: A report of 2 cases and a literature review
Q37725413Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting
Q38196931Prognostic factors, prognostic indices and staging in mycosis fungoides and Sézary syndrome: where are we now?
Q33598637Prognostic significance of CD30 expression in nasal natural killer/T-cell lymphoma
Q34649109Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan.
Q38191191Role of CD30 targeting in malignant lymphoma
Q64058873Single-Chain Variable Fragment-Based Bispecific Antibodies: Hitting Two Targets with One Sophisticated Arrow
Q58767936Spanish Lymphoma Group (GELTAMO) guidelines for the diagnosis, staging, treatment, and follow-up of diffuse large B-cell lymphoma
Q58011053Targeting CD30 expression in diverse Large B-cell lymphoma entities
Q54117760The Pathological Spectrum of Systemic Anaplastic Large Cell Lymphoma (ALCL).
Q99711031The clinicopathological and molecular features of sinusoidal large B-cell lymphoma
Q52955946The expression levels of JunB, JunD and p-c-Jun are positively correlated with tumor cell proliferation in diffuse large B-cell lymphomas.
Q35606714The expression of CD30 based on immunohistochemistry predicts inferior outcome in patients with diffuse large B-cell lymphoma
Q35607281The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma
Q90320490Using Gene Expression Profiling to Move Beyond MYC/BCL2 Rearrangements in High-Grade Lymphoma
Q36681461p63 expression confers significantly better survival outcomes in high-risk diffuse large B-cell lymphoma and demonstrates p53-like and p53-independent tumor suppressor function

Search more.