P63 regulates tubular formation via epithelial-to-mesenchymal transition

scientific article published on March 20, 2014

P63 regulates tubular formation via epithelial-to-mesenchymal transition is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2013.101
P953full work available at URLhttps://doi.org/10.1038/onc.2013.101
https://europepmc.org/articles/PMC4905556
https://europepmc.org/articles/pmc4905556?pdf=render
https://europepmc.org/articles/PMC4905556?pdf=render
https://www.nature.com/articles/onc2013101
https://www.nature.com/articles/onc2013101.pdf
P932PMC publication ID4905556
P698PubMed publication ID23542170
P5875ResearchGate publication ID236093501

P2093author name stringY. Zhang
X. Chen
W. Yan
P2860cites workp63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
The p53 family member genes are involved in the Notch signal pathwayQ24291822
A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasisQ24312492
Cloning and functional analysis of human p51, which structurally and functionally resembles p53Q24314965
Regulation of p63 isoforms by snail and slug transcription factors in human squamous cell carcinomaQ24617555
TAp63 prevents premature aging by promoting adult stem cell maintenanceQ24618256
Role of DeltaNp63gamma in epithelial to mesenchymal transitionQ24632945
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2Q24646996
Perp is a p63-regulated gene essential for epithelial integrity.Q45345452
Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures.Q46150566
Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis.Q46366404
Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epitheliaQ46788585
Significance of p63 amplification and overexpression in lung cancer development and prognosis.Q47390579
Three-dimensional sonographic findings associated with ectrodactyly ectodermal dysplasia clefting syndromeQ57923004
Bone Morphogenic Protein-7 Induces Mesenchymal to Epithelial Transition in Adult Renal Fibroblasts and Facilitates Regeneration of Injured KidneyQ58214852
A cell line derived from normal dog kidney (MDCK) exhibiting qualities of papillary adenocarcinoma and of renal tubular epitheliumQ68463064
Morphogenetic clonal growth of kidney epithelial cell line MDCKQ69010904
Frequent alteration of p63 expression in human primary bladder carcinomasQ74052241
Pattern of p63 mutations and their phenotypes--updateQ83324807
Epithelial-mesenchymal transitions in development and diseaseQ27860630
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Q27861068
Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndromeQ28146059
Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injuryQ28251154
ERK and MMPs sequentially regulate distinct stages of epithelial tubule developmentQ28270645
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentQ28587664
p63 is a p53 homologue required for limb and epidermal morphogenesisQ28588206
p63 deficiency activates a program of cellular senescence and leads to accelerated agingQ28592969
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?Q29547559
LGN regulates mitotic spindle orientation during epithelial morphogenesisQ30434467
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancerQ30525287
TAp63 induces senescence and suppresses tumorigenesis in vivoQ34060915
P63 gene mutations and human developmental syndromes.Q34152571
Cell surface polarity in epithelia.Q34195966
DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.Q34353609
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAsQ34662448
Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteinsQ34783580
The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutationsQ34784078
Tubulogenesis in the developing mammalian kidneyQ34793328
Mutant p53 Disrupts MCF-10A Cell Polarity in Three-dimensional Culture via Epithelial-to-mesenchymal TransitionsQ34963520
Distinct roles of cadherin-6 and E-cadherin in tubulogenesis and lumen formationQ35041609
Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigmQ35740652
PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathwayQ37143062
Biomarkers for epithelial-mesenchymal transitionsQ37209254
Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axesQ37661416
p63, a Story of Mice and MenQ37862578
Early organogenesis of the kidneyQ39611879
Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor.Q39894796
Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survivalQ39941908
p63 regulates an adhesion programme and cell survival in epithelial cellsQ40277208
The Hay Wells syndrome-derived TAp63alphaQ540L mutant has impaired transcriptional and cell growth regulatory activity.Q40345592
Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factorsQ41669104
The origin of renal fibroblasts and progression of kidney diseaseQ42235250
p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation.Q42539520
Completing the sequence of the Sulfolobus solfataricus P2 genomeQ43025906
p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genesQ43652191
A dominant-negative form of p63 is required for epidermal proliferation in zebrafish.Q43997050
Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectodermQ43997054
Dominant negative p63 isoform expression in head and neck squamous cell carcinomaQ45163378
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)1548-1557
P577publication date2013-04-01
2014-03-20
P1433published inOncogeneQ1568657
P1476titleP63 regulates tubular formation via epithelial-to-mesenchymal transition
P478volume33

Reverse relations

cites work (P2860)
Q92104526Ectrodactyly-ectodermal dysplasia-clefting syndrome with unusual cutaneous vitiligoid and psoriasiform lesions due to a novel single point TP63 gene mutation
Q46234676Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
Q30791965Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial-mesenchymal transition.
Q91340091Impact of Media in Transport Study on Cell Monolayer Integrity and Permeability
Q35081210Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells
Q27333756Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.
Q35987262P73 tumor suppressor and its targets, p21 and PUMA, are required for madin-darby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition
Q34938075Poly (C)-Binding Protein 1 Regulates p63 Expression through mRNA Stability
Q49891114Preoperative chemotherapy with docetaxel, cisplatin, and 5-fluorouracil for locally advanced esophageal carcinosarcoma: a case report and review of the literature
Q38288544Role of epithelial mesenchymal transition in prostate tumorigenesis
Q90644592Serine 195 phosphorylation in the RNA-binding protein Rbm38 increases p63 expression by modulating Rbm38's interaction with the Ago2-miR203 complex
Q33555190TAp63 suppress metastasis via miR-133b in colon cancer cells
Q46421500TAp63γ and ΔNp63γ are regulated by RBM38 via mRNA stability and have an opposing function in growth suppression
Q34999137The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells
Q33719411ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis
Q54217794ΔNp63γ/SRC/Slug signalling axis promotes epithelial-to-mesenchymal transition in squamous cancers.

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