Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults

scientific article published on April 2013

Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1164/RCCM.201212-2277OC
P932PMC publication ID3707375
P698PubMed publication ID23370916

P50authorDaniel R. NeillQ41681295
Stephen B. GordonQ42703812
Mathieu BangertQ47708130
David GoldblattQ51053608
Daniela M FerreiraQ57005808
Shaun H PenningtonQ58765120
Eliane N MiyajiQ58765151
Aras KadiogluQ61609002
P2093author name stringJenna F Gritzfeld
Adam K A Wright
Angela D Wright
Laura Bricio-Moreno
Andrea M Collins
Nicola Green
Adriana T Moreno
P2860cites workRegulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children.Q41827353
Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse modelQ42171376
The immune response to pneumococcal proteins during experimental human carriageQ42944608
Vaccine-induced human antibodies to PspA augment complement C3 deposition on Streptococcus pneumoniae.Q43078345
Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalitiesQ46898607
Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age.Q53083052
The current burden of pneumococcal disease in England and WalesQ57385772
Nasopharyngeal carriage with Streptococcus pneumoniae augments the immunizing effect of pneumolysin toxoid BQ58043338
Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosisQ59244201
Lack of pneumococcal carriage in the hospitalised elderlyQ61911776
Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) variant stimulates broadly cross-reactive antibodies to heterologous PspA moleculesQ73502898
Natural development of antibodies to pneumococcal capsular polysaccharides depends on the serotype: association with pneumococcal carriage and acute otitis media in young childrenQ74332994
Recognition of pneumococcal isolates by antisera raised against PspA fragments from different cladesQ80738099
Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?Q24809188
Comparison of a new multiplex binding assay versus the enzyme-linked immunosorbent assay for measurement of serotype-specific pneumococcal capsular polysaccharide IgGQ28392402
Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisationQ28744146
Interleukin-17A mediates acquired immunity to pneumococcal colonizationQ33370537
Immunization of mice with single PspA fragments induces antibodies capable of mediating complement deposition on different pneumococcal strains and cross-protection.Q33725192
Potential role for mucosally active vaccines against pneumococcal pneumoniaQ33792681
Comparison between nasopharyngeal swab and nasal wash, using culture and PCR, in the detection of potential respiratory pathogensQ33871573
CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonizationQ33935327
Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: relationships with pneumococcal colonization.Q33996628
Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriageQ34229627
Standardization of an opsonophagocytic assay for the measurement of functional antibody activity against Streptococcus pneumoniae using differentiated HL-60 cellsQ35229917
Streptococcus pneumoniae colonisation: the key to pneumococcal diseaseQ35681330
Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice.Q35784046
Niche and neutral effects of acquired immunity permit coexistence of pneumococcal serotypesQ35927343
Epidemiological differences among pneumococcal serotypesQ36024118
Inflammation markers predicting frailty and mortality in the elderly.Q36388062
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humansQ36658296
Experimental human pneumococcal carriage.Q36695032
Effects of ageing and gender on naturally acquired antibodies to pneumococcal capsular polysaccharides and virulence-associated proteinsQ36898018
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and diseaseQ37109940
Antibodies to pneumococcal proteins PhtD, CbpA, and LytC in Filipino pregnant women and their infants in relation to pneumococcal carriageQ37213916
Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in miceQ37241352
The pneumococcus: why a commensal misbehavesQ37629673
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.Q39910189
Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonizationQ39912979
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectStreptococcus pneumoniaeQ221179
P304page(s)855-864
P577publication date2013-04-01
P1433published inAmerican Journal of Respiratory and Critical Care MedicineQ4744267
P1476titleControlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults
P478volume187

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cites work (P2860)
Q89554855A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease
Q64119526A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Challenge
Q48125700A milestone in the investigation of population-wide effects of vaccines.
Q94603399A pneumococcal controlled human infection model in Malawi: Transfer of an established pneumococcal carriage model from Liverpool, UK to Blantyre, Malawi - A feasibility study
Q41445924Absence of Streptococcus pneumoniae in pharyngeal swabs of geriatric inpatients
Q38255618Age-related immune response to pneumococcal polysaccharide vaccination: lessons for the clinic
Q37675714Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage
Q55491630Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging.
Q52715343Antibodies Reactive to Commensal Streptococcus mitis Show Cross-Reactivity With Virulent Streptococcus pneumoniae Serotypes.
Q41436543Antibody Response is More Likely to Pneumococcal Proteins Than to Polysaccharide After HIV-associated Invasive Pneumococcal Disease
Q37264678CD4 T cell memory and antibody responses directed against the pneumococcal histidine triad proteins PhtD and PhtE following nasopharyngeal colonization and immunization and their role in protection against pneumococcal colonization in mice
Q35806621Clinical and Microbiological Factors Associated with High Nasopharyngeal Pneumococcal Density in Patients with Pneumococcal Pneumonia
Q88068954Colonization-induced protection against invasive pneumococcal disease in mice is independent of CD103 driven adaptive immune responses
Q90340982Controlled human infection with Bordetella pertussis induces asymptomatic, immunising colonisation
Q27009175Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus
Q35635685Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy
Q34479487Density and duration of pneumococcal carriage is maintained by transforming growth factor β1 and T regulatory cells
Q30279261Design, recruitment, and microbiological considerations in human challenge studies.
Q39123904Dynamics of pneumococcal carriage among day-care center attendees during the transition from the 7-valent to the higher-valent pneumococcal conjugate vaccines in Greece.
Q56378326Experimental infection of human volunteers
Q34794776Expression of Streptococcus pneumoniae Virulence-Related Genes in the Nasopharynx of Healthy Children
Q38950882First human challenge testing of a pneumococcal vaccine. Double-blind randomized controlled trial
Q35855909Genetic stability of pneumococcal isolates during 35 days of human experimental carriage
Q56912161Identifying human encounters that shape the transmission of Streptococcus pneumoniae and other acute respiratory infections
Q38185814Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions
Q33734282Impact of experimental human pneumococcal carriage on nasopharyngeal bacterial densities in healthy adults
Q37086940Increased IgG but normal IgA anti-pneumococcal protein antibodies in lung of HIV-infected adults
Q58105793Inflammation induced by influenza virus impairs human innate immune control of pneumococcus
Q92285842Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization
Q91665960Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine
Q35113446Low prevalence of pneumococcal carriage and high serotype and genotype diversity among adults over 60 years of age living in Portugal
Q38984814Macrophage migration inhibitory factor promotes clearance of pneumococcal colonization
Q64076710Mechanisms of Naturally Acquired Immunity to
Q91936430Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface
Q36438285Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage
Q90471605Mouse IgG2a Antibodies Specific for the Commensal Streptococcus mitis Show Stronger Cross-Reactivity with Streptococcus pneumoniae than IgG1 Antibodies
Q55633626Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138+ Cells.
Q38768647Nasopharyngeal colonization with Streptococcus pneumoniae triggers dendritic cell dependent antibody responses against invasive disease in mice
Q36263931Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens
Q37287225Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization.
Q34078369Pathogen evolution and the immunological niche
Q38861144Pneumococcal Capsular Polysaccharide Immunity in the Elderly
Q36734938Pneumococcal Colonization Rates in Patients Admitted to a United Kingdom Hospital with Lower Respiratory Tract Infection: a Prospective Case-Control Study
Q90186763Pneumococcal colonisation is an asymptomatic event in healthy adults using an experimental human colonisation model
Q62487380Pneumococcal colonization in healthy adult research participants in the conjugate vaccine era, United Kingdom, 2010-2017
Q49352945Pneumococcal conjugate vaccine 13 delivered as one primary and one booster dose (1 + 1) compared with two primary doses and a booster (2 + 1) in UK infants: a multicentre, parallel group randomised controlled trial
Q37559933Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage
Q41612508Promises and pitfalls of live attenuated pneumococcal vaccines
Q39147459Protection against Streptococcus pneumoniae Invasive Pathogenesis by a Protein-Based Vaccine Is Achieved by Suppression of Nasopharyngeal Bacterial Density during Influenza A Virus Coinfection
Q35154329Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses
Q37309218Rationale and prospects for novel pneumococcal vaccines
Q58586401Role of Inflammatory Risk Factors in the Pathogenesis of
Q34196888Serological response to 13-valent pneumococcal conjugate vaccine in children and adolescents with perinatally acquired HIV infection
Q92700350Serotype-Independent Protection Against Invasive Pneumococcal Infections Conferred by Live Vaccine With lgt Deletion
Q38177271Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design.
Q52337590Streptococcus pneumoniae: transmission, colonization and invasion.
Q89609370Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx
Q33627684The Alpha-Tocopherol Form of Vitamin E Boosts Elastase Activity of Human PMNs and Their Ability to Kill Streptococcus pneumoniae
Q89975815The Dynamics of Respiratory Microbiota during Mechanical Ventilation in Patients with Pneumonia
Q35068763The adult nasopharyngeal microbiome as a determinant of pneumococcal acquisition
Q104517897The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae
Q28084920The host immune dynamics of pneumococcal colonization: implications for novel vaccine development
Q48364114The immunological mechanisms that control pneumococcal carriage.
Q91705453The low carriage prevalence of pneumococcus among community-dwelling older people: A cross-sectional study in Japan
Q35224554Unveiling time in dose-response models to infer host susceptibility to pathogens.
Q35199001Update in sepsis and pulmonary infections 2013.
Q94545406Vaccines to Prevent Infectious Diseases in the Older Population: Immunological Challenges and Future Perspectives
Q40409110Were Antibody Titers the Right Parameter When Immunologically Comparing Pneumococcal Vaccines?

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