Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age.

scientific article published on 8 April 2011

Th17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VACCINE.2011.03.081
P8608Fatcat IDrelease_cpw4uz64efa55kc3ndgtn7gqzi
P698PubMed publication ID21481328

P50authorBeatrix Grubeck-LoebensteinQ21255470
P2093author name stringMichael Keller
Stefan Seidel
Sanja Selak
Eszter Nagy
Christoph Reinisch
Karen Lingnau
Petra Schlick
Petra Schmid
Zoltan Magyarics
Barbara Luhan
P2860cites workVaccines in the era of genomics: the pneumococcal challengeQ28290283
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cellsQ29618163
Prevention of pneumococcal disease in mice immunized with conserved surface-accessible proteinsQ33202131
Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodiesQ33312893
Initial and subsequent response to pneumococcal polysaccharide and protein-conjugate vaccines administered sequentially to adults who have recovered from pneumococcal pneumoniaQ33360868
Interleukin-17A mediates acquired immunity to pneumococcal colonizationQ33370537
Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children.Q41827353
Challenges for vaccination in the elderly.Q41957098
The immune response to pneumococcal proteins during experimental human carriageQ42944608
The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitroQ43132784
T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and diseaseQ43645903
Natural development of antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A, and pneumolysin in relation to pneumococcal carriage and acute otitis mediaQ44836024
Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulatorQ45014787
Characterization of a eukaryotic type serine/threonine protein kinase and protein phosphatase of Streptococcus pneumoniae and identification of kinase substrates.Q45273413
Regulation of IL-17 in human CCR6+ effector memory T cells.Q51964294
Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children.Q51977040
Altered memory B-cell homeostasis in human aging.Q52011425
The Immunogenicity of 7‐Valent Pneumococcal Conjugate Vaccine versus 23‐Valent Polysaccharide Vaccine in Adults Aged 50–80 YearsQ57385750
Reactogenicity and immunogenicity of a protein-conjugated pneumococcal oligosaccharide vaccine in older adultsQ71007455
Persistence of cell-mediated immunity and decline of humoral immunity to the intracellular bacterium Francisella tularensis 25 years after natural infectionQ72022248
Immunization of humans with recombinant pneumococcal surface protein A (rPspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspAQ73166608
Functional analysis of a PcsB-deficient mutant of group B streptococcusQ73269246
Human antibodies to pneumococcal surface protein A in health and diseaseQ73491325
Pneumococcal carriage and otitis media induce salivary antibodies to pneumococcal surface adhesin a, pneumolysin, and pneumococcal surface protein a in childrenQ73585328
A eukaryotic-type serine/threonine protein kinase StkP of Streptococcus pneumoniae acts as a dimer in vivoQ79791550
Booster vaccination in the elderly: their success depends on the vaccine type applied earlier in life as well as on pre-vaccination antibody titersQ80006417
Precise answers to the wrong question: prospective clinical trials and the meta-analyses of pneumococcal vaccine in elderly and high-risk adultsQ80128843
Serum antibodies to the pneumococcal surface proteins PhtB and PhtE in Finnish infants and adultsQ80237417
Insufficient protection for healthy elderly adults by tetanus and TBE vaccinesQ81661572
Effectiveness of the pneumococcal polysaccharide vaccine in preventing pneumonia in the elderlyQ82518964
T cell responses are better correlates of vaccine protection in the elderlyQ83276474
Effectiveness of the 23-valent polysaccharide pneumococcal vaccine against invasive pneumococcal disease in people 60 years or olderQ33542866
Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriageQ33798317
Age-associated increased interleukin-6 gene expression, late-life diseases, and frailtyQ33896033
Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center GroupQ33896897
Efficacy of a pneumococcal conjugate vaccine against acute otitis mediaQ33932973
CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonizationQ33935327
Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trialQ33986009
Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination.Q34001923
Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniaeQ34003306
Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsisQ34005995
Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells.Q34768051
Dynamics of nasopharyngeal colonization by potential respiratory pathogensQ35056169
Streptococcus pneumoniae colonisation: the key to pneumococcal diseaseQ35681330
Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae.Q35689099
Eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniaeQ35879288
Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes.Q36089312
Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humansQ36183460
B cell development and receptor diversity during agingQ36213043
Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteinsQ36313904
Inflammation markers predicting frailty and mortality in the elderly.Q36388062
Antibody quality in old age.Q36445511
Streptococcus pneumoniae protein vaccine candidates: properties, activities and animal studiesQ36558990
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humansQ36658296
B-cell diversity decreases in old age and is correlated with poor health statusQ37155196
Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in miceQ37190966
Influences of capsule on cell shape and chain formation of wild-type and pcsB mutants of serotype 2 Streptococcus pneumoniae.Q37191467
The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation.Q37280352
Pneumococcal vaccination of elderly adults: new paradigms for protection.Q37290048
Immunosenescence and vaccine failure in the elderlyQ37538366
Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine developmentQ37668036
Immune responses to novel pneumococcal proteins pneumolysin, PspA, PsaA, and CbpA in adenoidal B cells from childrenQ39656521
The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease.Q39910189
Human antibody response towards the pneumococcal surface proteins PspA and PspC during invasive pneumococcal infectionQ40285793
The proline-rich region of pneumococcal surface proteins A and C contains surface-accessible epitopes common to all pneumococci and elicits antibody-mediated protection against sepsisQ40332317
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)3982-3989
P577publication date2011-04-08
P1433published inVaccineQ7907941
P1476titleTh17/Th1 biased immunity to the pneumococcal proteins PcsB, StkP and PsaA in adults of different age.
P478volume29

Reverse relations

cites work (P2860)
Q64119526A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Challenge
Q35668540A Serine-Threonine Kinase (StkP) Regulates Expression of the Pneumococcal Pilus and Modulates Bacterial Adherence to Human Epithelial and Endothelial Cells In Vitro
Q36013814Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country
Q36731284Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses
Q36999810Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults
Q47658958Development of pneumococcal vaccines over the last 10 years
Q38140041Exploitation of physiology and metabolomics to identify pneumococcal vaccine candidates
Q39037134Genetic conjugation of components in two pneumococcal fusion protein vaccines enhances paediatric mucosal immune responses
Q90602359Immunologic Dysfunction Contributes to the Otitis Prone Condition
Q90136333Immunosenescence and human vaccine immune responses
Q38185814Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions
Q24625664Interleukin-17 production and T helper 17 cells in peripheral blood mononuclear cells in response to ocular lysate in patients with birdshot chorioretinopathy
Q58596157Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation
Q35665351Novel protein-based pneumococcal vaccines administered with the Th1-promoting adjuvant IC31 induce protective immunity against pneumococcal disease in neonatal mice
Q37309218Rationale and prospects for novel pneumococcal vaccines
Q27009118Recent advances in pneumococcal peptidoglycan biosynthesis suggest new vaccine and antimicrobial targets
Q38069943Serotype-independent pneumococcal vaccines.
Q39146450The contrasting roles of Th17 immunity in human health and disease
Q92968776Vaccination for the control of childhood bacterial pneumonia - Haemophilus influenzae type b and pneumococcal vaccines

Search more.