Nuclear receptors in macrophages: a link between metabolism and inflammation.

scientific article

Nuclear receptors in macrophages: a link between metabolism and inflammation. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.FEBSLET.2007.11.020
P698PubMed publication ID18022390
P5875ResearchGate publication ID5825515

P50authorTamás RöszerQ57323163
P2093author name stringAttila Szanto
P2860cites workMutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiencyQ22010457
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular CausesQ22250883
Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen speciesQ22253929
Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophagesQ24290466
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgammaQ24311702
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDLQ24311741
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathwayQ24316367
Reduction of atherosclerosis in mice by inhibition of CD40 signallingQ24316540
LXR, a nuclear receptor that defines a distinct retinoid response pathwayQ24317347
Synthetic LXR ligand inhibits the development of atherosclerosis in miceQ24530617
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbetaQ24553340
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in miceQ24623151
Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery diseaseQ44316923
Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouseQ44342113
Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient miceQ44633973
Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient miceQ44936555
Stem cell transplantation reveals that absence of macrophage CD36 is protective against atherosclerosisQ45108277
The mouse CCR2 gene is regulated by two promoters that are responsive to plasma cholesterol and peroxisome proliferator-activated receptor gamma ligands.Q46003373
Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2.Q46445868
The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) miceQ46530547
Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient miceQ46537797
Pioglitazone attenuates TGF-beta(1)-induction of fibronectin synthesis and its splicing variant in human mesangial cells via activation of peroxisome proliferator-activated receptor (PPAR)gammaQ46626934
Blockade of interleukin-12 function by protein vaccination attenuates atherosclerosisQ46652738
PPAR-gamma agonists inhibit toll-like receptor-mediated activation of dendritic cells via the MAP kinase and NF-kappaB pathwaysQ46655077
Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosisQ46897070
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein SlimbQ47070747
Natural killer T cells accelerate atherogenesis in miceQ47685326
Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase geneQ48010812
Requirement for CD154 in the progression of atherosclerosis.Q52536870
Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.Q52541069
Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice.Q52549466
Granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor exacerbate atherosclerosis in apolipoprotein E-deficient mice.Q53562008
Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.Q53574931
Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.Q53591929
Activation of PPARalpha or gamma reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells.Q54256900
Natural regulatory T cells control the development of atherosclerosis in miceQ58149268
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infectionQ59068486
The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.Q42497873
Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- miceQ42757050
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammationQ42832963
27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cellsQ43706818
Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice.Q43794492
Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient miceQ43893171
Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- miceQ43909351
Subendothelial retention of atherogenic lipoproteins in early atherosclerosisQ44029239
Interleukin 12 induces T-cell recruitment into the atherosclerotic plaqueQ44043461
Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemiaQ44066949
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesisQ44121998
AtherosclerosisQ24644573
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alphaQ24683359
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgammaQ24685818
The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier diseaseQ28141040
Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1Q28141056
Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterolsQ28143718
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesisQ28199913
Reciprocal regulation of inflammation and lipid metabolism by liver X receptorsQ28202771
Transcriptional repression of atherogenic inflammation: modulation by PPARdeltaQ28206569
Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophagesQ28215677
CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humansQ28218369
An oxysterol signalling pathway mediated by the nuclear receptor LXR alphaQ28294042
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitmentQ28298072
A major role for VCAM-1, but not ICAM-1, in early atherosclerosisQ28365883
Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophagesQ28378773
Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenaseQ28587071
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout miceQ28591350
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gammaQ28593737
Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathwaysQ28613243
Cerebrotendinous XanthomatosisQ29307222
Inflammation in atherosclerosisQ29547428
Atherosclerosis. the road aheadQ29618972
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activationQ29620219
Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligandsQ30819886
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.Q32085397
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient miceQ33236495
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosisQ33581637
Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic miceQ33905765
Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans.Q33944867
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein EQ33962949
Autoregulation of the human liver X receptor alpha promoterQ34012691
Modulation of atherosclerosis in mice by Toll-like receptor 2Q34063165
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.Q34277079
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaquesQ34327535
PPARdelta is a very low-density lipoprotein sensor in macrophagesQ34330290
Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.Q34377352
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptorQ34467451
Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammationQ34478995
Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.Q34479025
Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophageQ34479176
Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesisQ34620005
Pattern recognition receptors: doubling up for the innate immune responseQ35036522
Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion developmentQ35103176
PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophagesQ35144057
Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitisQ35633338
15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.Q35698498
The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient miceQ35792034
Thematic review series: The immune system and atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesisQ36011463
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosisQ36028683
PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cellsQ36227984
CD1d-dependent activation of NKT cells aggravates atherosclerosis.Q36399122
Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoproteinQ36501176
The immune response in atherosclerosis: a double-edged swordQ36508676
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein EQ36986664
Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient miceQ37242527
Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gammaQ37270009
Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis.Q37354660
Absence of P-selectin delays fatty streak formation in miceQ37364649
IFN-gamma potentiates atherosclerosis in ApoE knock-out miceQ37368296
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient miceQ37377448
The combined role of P- and E-selectins in atherosclerosisQ37387115
LXR-dependent gene expression is important for macrophage survival and the innate immune responseQ38335500
Peroxisome proliferator-activated receptor-gamma ligands inhibit TGF-beta 1-induced fibronectin expression in glomerular mesangial cellsQ38346577
Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophagesQ39961619
PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cellsQ40225700
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis developmentQ40391470
Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxideQ40517615
Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol MetabolismQ40622775
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.Q40743941
The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial LectureQ41010478
Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinaseQ41646524
PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1Q42109973
Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophagesQ42435836
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P304page(s)106-116
P577publication date2007-11-20
P1433published inFEBS LettersQ1388051
P1476titleNuclear receptors in macrophages: a link between metabolism and inflammation
P478volume582

Reverse relations

cites work (P2860)
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