Pharmacokinetics-pharmacodynamics and antitumor activity of mercaptoacetamide-based histone deacetylase inhibitors

scientific article published on 29 September 2009

Pharmacokinetics-pharmacodynamics and antitumor activity of mercaptoacetamide-based histone deacetylase inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1535-7163.MCT-09-0629
P932PMC publication ID3711100
P698PubMed publication ID19789216

P2093author name stringAlfredo Velena
Hong Cao
Mira Jung
Zacharoula Konsoula
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Histone deacetylase inhibitors open new doors in cancer therapyQ35864048
The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation.Q36371074
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Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cellsQ37011590
HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in ratsQ37120410
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Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.Q39026671
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A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.Q40477758
Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitorsQ40669828
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cellsQ40765366
Prostate specific antigen and androgen receptor induction and characterization of an immortalized adult human prostatic epithelial cell lineQ41180892
Transformation of human neonatal prostate epithelial cells by strontium phosphate transfection with a plasmid containing SV40 early region genesQ42814677
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion scheduleQ43763013
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamatesQ43879025
Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumorsQ44086974
Thiol-based SAHA analogues as potent histone deacetylase inhibitorsQ44900745
Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug designQ45189994
Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphomaQ46455509
P433issue10
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)2844-2851
P577publication date2009-09-29
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titlePharmacokinetics-pharmacodynamics and antitumor activity of mercaptoacetamide-based histone deacetylase inhibitors
P478volume8

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cites work (P2860)
Q38435029Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots
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Q89529397Understanding Failure and Improving Treatment Using HDAC Inhibitors for Prostate Cancer
Q41115468Valproic acid attenuates the expression of pro-inflammatory cytokines lipopolysaccharide-treated canine peripheral blood mononuclear cells (in vitro) and in a canine endotoxemia model (in vivo).

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