Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis

scientific article published on 29 May 2013

Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.469023
P932PMC publication ID3711336
P698PubMed publication ID23720776

P2093author name stringAnthony Carruthers
Di Deng
Kara B Levine
Julie K De Zutter
P2860cites workGlucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1Q24294593
Transmembrane segment 6 of the Glut1 glucose transporter is an outer helix and contains amino acid side chains essential for transport activityQ24310467
Supply and demand in cerebral energy metabolism: the role of nutrient transportersQ24671074
Single particle electron microscopy analysis of the bovine anion exchanger 1 reveals a flexible linker connecting the cytoplasmic and membrane domainsQ27316894
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Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coliQ27641769
Design, function and structure of a monomeric ClC transporterQ27665592
Equilibriums and kinetics of ligand binding to the human erythrocyte glucose transporter. Evidence for an alternating conformation model for transportQ70967923
Crystal structure of a bacterial homologue of glucose transporters GLUT1-4Q27682874
Structure of the multidrug transporter EmrD from Escherichia coliQ28238417
Glucose transporter proteins in brain: delivery of glucose to neurons and gliaQ28248997
Sequence and structure of a human glucose transporterQ28305569
Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library.Q30328726
The GxxxG motif: a framework for transmembrane helix-helix associationQ30839523
Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathwayQ33832542
The major facilitator superfamilyQ34004285
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators.Q34117304
Predicting the three-dimensional structure of the human facilitative glucose transporter glut1 by a novel evolutionary homology strategy: insights on the molecular mechanism of substrate migration, and binding sites for glucose and inhibitory molecuQ34187609
Simple Allosteric Model for Membrane PumpsQ34242760
Structural basis of human erythrocyte glucose transporter function in proteoliposome vesicles: circular dichroism measurementsQ34631362
Regulation of amino acid and glucose transporters in endothelial and smooth muscle cellsQ35035933
Structural basis of GLUT1 inhibition by cytoplasmic ATP.Q36074320
Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasisQ36197966
AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stressQ36312779
Sequence determinants of GLUT1-mediated accelerated-exchange transport: analysis by homology-scanning mutagenesisQ36466596
Aquaporin-4 square array assembly: opposing actions of M1 and M23 isoformsQ37089692
Model of the exofacial substrate-binding site and helical folding of the human Glut1 glucose transporter based on scanning mutagenesisQ37419540
Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promotes GLUT1 tetramerizationQ38292996
The red blood cell glucose transporter presents multiple, nucleotide-sensitive sugar exit sitesQ38293835
The human erythrocyte sugar transporter presents two sugar import sitesQ38317309
A modified, dual reporter TOXCAT system for monitoring homodimerization of transmembrane segments of proteinsQ38318639
Inhibitions of sugar transport produced by ligands binding at opposite sides of the membrane. Evidence for simultaneous occupation of the carrier by maltose and cytochalasin B.Q38335577
Equilibrium ligand binding to the human erythrocyte sugar transporter. Evidence for two sugar-binding sites per carrierQ38349365
Characterization of a mutation and an alternative splicing of UDP-galactose transporter in MDCK-RCAr cell lineQ40325660
Molecular determinants of sugar transport regulation by ATP.Q40697670
Transporters of nucleotide sugars, ATP, and nucleotide sulfate in the endoplasmic reticulum and Golgi apparatusQ40841104
Evidence that functional erythrocyte-type glucose transporters are oligomersQ41169871
Analysis of glucose transporter topology and structural dynamicsQ41868460
Rapid kinetics of the glucose transporter from human erythrocytes. Detection and measurement of a half-turnover of the purified transporterQ42229047
Abnormal SDS-PAGE migration of cytosolic proteins can identify domains and mechanisms that control surfactant bindingQ42533603
Transmembrane segment 3 of the Glut1 glucose transporter is an outer helixQ45016639
Properties of the human erythrocyte glucose transport protein are determined by cellular contextQ46431878
Glucose transport carrier of human erythrocytes. Radiation-target size of glucose-sensitive cytochalasin B binding protein.Q47298637
Analysis of the oligomeric state of Band 3, the anion transport protein of the human erythrocyte membrane, by size exclusion high performance liquid chromatography. Oligomeric stability and origin of heterogeneityQ47426088
Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteinsQ48418596
Topology of the Glut 1 glucose transporter deduced from glycosylation scanning mutagenesisQ49092757
Transmembrane segment 12 of the Glut1 glucose transporter is an outer helix and is not directly involved in the transport mechanism.Q50644095
Testing and characterizing the simple carrierQ68827936
Fourier transform infrared spectroscopic study of the structure and conformational changes of the human erythrocyte glucose transporterQ69752972
Cholate-solubilized erythrocyte glucose transporters exist as a mixture of homodimers and homotetramersQ70150096
P433issue28
P407language of work or nameEnglishQ1860
P304page(s)20734-20744
P577publication date2013-05-29
P1433published inJournal of Biological ChemistryQ867727
P1476titleSequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesis
P478volume288

Reverse relations

cites work (P2860)
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Q37054474Determination of GLUT1 Oligomerization Parameters using Bioluminescent Förster Resonance Energy Transfer
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Q88643832Intestinal Absorption of Fructose
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Q40373924Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.
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Q30395148WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site

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