Reconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters

scientific article published on 24 October 2017

Reconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M117.815589
P932PMC publication ID5743077
P698PubMed publication ID29066623

P2093author name stringAnthony Carruthers
Kenneth P Lloyd
Julie K De Zutter
Ogooluwa A Ojelabi
P2860cites workGlucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1Q24294593
Molecular basis of ligand recognition and transport by glucose transportersQ24338453
Asymmetry of the hexose transfer system in human erythrocytes. Comparison of the effects of cytochalasin B, phloretin and maltose as competitive inhibitorsQ24537539
Structure and mechanism of the mammalian fructose transporter GLUT5Q27315967
Structure and mechanism of the lactose permease of Escherichia coliQ27641768
Crystal structure of a bacterial homologue of glucose transporters GLUT1-4Q27682874
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transportersQ27684502
Inability of diffusion to account for placental glucose transfer in the sheep and consideration of the kinetics of a possible carrier transferQ72990333
Ultrastructure of human erythrocyte GLUT1Q79790224
Crystal structure of the human glucose transporter GLUT1Q27690274
CASTp: computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residuesQ27860729
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracyQ28251042
Sequence and structure of a human glucose transporterQ28305569
Evidence for two asymmetric conformational states in the human erythrocyte sugar-transport systemQ28339324
Structural requirements for binding to the sugar-transport system of the human erythrocyteQ28363901
ZINC: a free tool to discover chemistry for biologyQ29615857
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexesQ29616736
Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screeningQ29617343
WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding SiteQ30395148
Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathwayQ33832542
Determinants of ligand binding affinity and cooperativity at the GLUT1 endofacial siteQ33839891
Simple Allosteric Model for Membrane PumpsQ34242760
Structural basis of GLUT1 inhibition by cytoplasmic ATP.Q36074320
Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasisQ36197966
Sequence determinants of GLUT1-mediated accelerated-exchange transport: analysis by homology-scanning mutagenesisQ36466596
Three-dimensional crystallization of the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamilyQ36631486
Sequence determinants of GLUT1 oligomerization: analysis by homology-scanning mutagenesisQ37012553
Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promotes GLUT1 tetramerizationQ38292996
The red blood cell glucose transporter presents multiple, nucleotide-sensitive sugar exit sitesQ38293835
The human erythrocyte sugar transporter presents two sugar import sitesQ38317309
Quench-flow analysis reveals multiple phases of GluT1-mediated sugar transportQ38330655
Inhibitions of sugar transport produced by ligands binding at opposite sides of the membrane. Evidence for simultaneous occupation of the carrier by maltose and cytochalasin B.Q38335577
Equilibrium ligand binding to the human erythrocyte sugar transporter. Evidence for two sugar-binding sites per carrierQ38349365
Evidence that functional erythrocyte-type glucose transporters are oligomersQ41169871
Evidence of multiple operational affinities for d-glucose inside the human erythrocyte membraneQ41439585
Purification of the cytochalasin B binding component of the human erythrocyte monosaccharide transport systemQ41544799
Rapid substrate translocation by the multisubunit, erythroid glucose transporter requires subunit associations but not cooperative ligand bindingQ41677900
Reptation-induced coalescence of tunnels and cavities in Escherichia Coli XylE transporter conformers accounts for facilitated diffusionQ42133717
The major facilitator superfamily (MFS) revisitedQ42213199
Presteady-state uptake of glucose by the human erythrocyte is inconsistent with the mobile carrier modelQ43463518
Mechanisms for the facilitated diffusion of substrates across cell membranesQ45164543
A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose TransportersQ48013076
Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteinsQ48418596
Testing and characterizing the simple carrierQ68827936
The asymmetry of the facilitated transfer system for hexoses in human red cells and the simple kinetics of a two component modelQ69545527
Radiation inactivation of the human erythrocyte nucleoside and glucose transportersQ70012524
Cholate-solubilized erythrocyte glucose transporters exist as a mixture of homodimers and homotetramersQ70150096
Binding of cytochalasin B to human erythrocyte glucose transporterQ70656325
Equilibriums and kinetics of ligand binding to the human erythrocyte glucose transporter. Evidence for an alternating conformation model for transportQ70967923
Sugar transport in giant axons of LoligoQ71046587
Human erythrocyte sugar transport is incompatible with available carrier modelsQ71395205
P433issue51
P407language of work or nameEnglishQ1860
P304page(s)21035-21046
P577publication date2017-10-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleReconciling contradictory findings: Glucose transporter 1 (GLUT1) functions as an oligomer of allosteric, alternating access transporters
P478volume292

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cites work (P2860)
Q59329006Chemical biology probes of mammalian GLUT structure and function
Q92057661Extracellular gating of glucose transport through GLUT 1
Q99351936Glut1 Deficiency Syndrome (Glut1DS): State of the art in 2020 and recommendations of the international Glut1DS study group
Q47325234Kinetic Basis of Cis- and Trans-Allostery in GLUT1-Mediated Sugar Transport
Q55005789Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery.
Q61442969New insights into GluT1 mechanics during glucose transfer
Q58558259Red wine and green tea flavonoids are cis-allosteric activators and competitive inhibitors of GLUT1-mediated sugar uptake
Q64907382Transporter oligomerisation: roles in structure and function.

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