Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery

scientific article published on 22 January 2009

Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/STROKEAHA.108.531236
P932PMC publication ID3718309
P698PubMed publication ID19164788

P50authorJames A. BlumenthalQ88513900
Barbara Phillips-ButeQ115549094
P2093author name stringDaniel T Laskowitz
Donald D Glower
Hilary P Grocott
Joseph P Mathew
Mark F Newman
G Burkhard Mackensen
Neurologic Outcome Research Group (NORG) of the Duke Heart Center
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Cognitive change 5 years after coronary artery bypass surgeryQ34279265
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Lidocaine in the treatment of decompression illness: a review of the literature.Q34687513
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Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various agesQ36634164
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Lidocaine infusions: effect of duration and method of discontinuation on recurrence of arrhythmias and pharmacokinetic variablesQ41718792
Effect of the duration of infusion on the disposition of lidocaine in dogsQ42596848
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Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgeryQ43783508
Effect of experimental diabetes on pharmacokinetic parameters of lidocaine and MEGX in ratsQ44634227
Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in ratsQ44852860
Lidocaine impairs vasodilation mediated by adenosine triphosphate-sensitive K+ channels but not by inward rectifier K+ channels in rat cerebral microvesselsQ45034045
Lidocaine delays cortical ischemic depolarization: relationship to electrophysiologic recovery and neuropathologyQ48150111
Cerebral protection by lidocaine during cardiac operationsQ48216002
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An evaluation of the effect of lidocaine in experimental focal cerebral ischemiaQ48302778
Neuroprotection of the brain during cardiopulmonary bypass: a randomized trial of remacemide during coronary artery bypass in 171 patientsQ48357237
Effect of lidocaine on somatosensory evoked response and cerebral blood flow after canine cerebral air embolismQ48425244
The effects of lidocaine on canine cerebral metabolism and circulation related to the electroencephalogram.Q48558841
Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderlyQ48561058
Lidocaine metabolism in isolated perfused liver from streptozotocin-induced diabetic ratsQ48677642
Neurocognitive deficit following coronary artery bypass grafting: a prospective study of surgical patients and nonsurgical controlsQ48864614
Brain microemboli during cardiac surgery or aortographyQ48886524
The effect of lidocaine on early postoperative cognitive dysfunction after coronary artery bypass surgeryQ49023484
Cerebral arterial gas embolism by helium: an unusual case successfully treated with hyperbaric oxygen and lidocaine.Q51416030
Influence of lidocaine on endotoxin-induced leukocyte-endothelial cell adhesion and macromolecular leakage in vivo.Q51535992
Lidocaine reduces the hypoxia-induced release of an excitatory amino acid analog from rat striatal slices in superfusion.Q51595098
Statement of consensus on assessment of neurobehavioral outcomes after cardiac surgery.Q51604307
Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials.Q51619927
Lidocaine protects hippocampal neurons against ischemic damage by preventing increase of extracellular excitatory amino acids: a microdialysis study in Mongolian gerbils.Q51624967
The pharmacokinetics and pharmacodynamics of lignocaine and MEGX in healthy subjects.Q51792100
Reduction of experimental intracranial hypertension by lidocaine.Q51792269
Lidocaine constricts or dilates rat arterioles in a dose-dependent manner.Q51831269
Protective effect of lidocaine in acute cerebral ischemia induced by air embolism.Q51848363
Inhibition of Cerebral Oxygen and Glucose Consumption in the Dog by Hypothermia, Pentobarbital, and LidocaineQ51865990
Pharmacokinetic Principles of Lidocaine Dosing in Relation to Disease StateQ51868222
Lidocaine inhibits granulocyte adherence and prevents granulocyte delivery to inflammatory sites.Q51875061
Pharmacokinetics of lidocaine after prolonged intravenous infusions in uncomplicated myocardial infarction.Q52707629
Influence of congestive heart failure on blood levels of lidocaine and its active monodeethylated metaboliteQ52717137
The convulsant potency of lidocaine and its N-dealkylated metabolitesQ52729244
Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic ratsQ73944477
Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgeryQ80324479
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcardiac surgeryQ235007
placeboQ269829
lidocaineQ216935
P304page(s)880-887
P577publication date2009-01-22
P1433published inStroke JournalQ7624282
P1476titleRandomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery
P478volume40

Reverse relations

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