SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers

scientific article published on April 2013

SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MAM.2012.05.001
P932PMC publication ID3724465
P698PubMed publication ID23506868
P5875ResearchGate publication ID236059324

P2093author name stringMark Donowitz
C Ming Tse
Daniel Fuster
P2860cites workNa+ channel expression and neuronal function in the Na+/H+ exchanger 1 null mutant mouse.Q48411517
Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological diseaseQ50335672
Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9.Q50461676
Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures.Q52177965
Intracellular sequestration of sodium by a novel Na+/H+ exchanger in yeast is enhanced by mutations in the plasma membrane H+-ATPase. Insights into mechanisms of sodium tolerance.Q52527519
Identification and biochemical characterization of the SLC9A7 interactome.Q52588312
Effect of mutations affecting Na+: H+ antiport activity on tumorigenic potential of hamster lung fibroblasts.Q53523434
Amiloride enhances postischemic ventricular recovery: possible role of Na+-H+ exchangeQ69836543
NHE2 and NHE3 are human and rabbit intestinal brush-border proteinsQ71441670
Heterologous expression of rat NHE4: a highly amiloride-resistant Na+/H+ exchanger isoformQ73085868
The epithelial Na(+)/H(+) exchanger, NHE3, is internalized through a clathrin-mediated pathwayQ73297480
Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubuleQ74599385
In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrheaQ78346293
Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileumQ80775988
Na+/H+ exchanger isoform 6 (NHE6/SLC9A6) is involved in clathrin-dependent endocytosis of transferrinQ84863941
Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi networkQ24291060
Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondriaQ24293474
Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7Q24300303
Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulationQ24310771
IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calciumQ24317729
beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoformQ24556620
Identifying autism loci and genes by tracing recent shared ancestryQ24655308
Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1Q24681699
Structure of Human Na+/H+ Exchanger NHE1 Regulatory Region in Complex with Calmodulin and Ca2+Q27674259
Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBTQ27674756
The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle traffickingQ27936889
A novel topology model of the human Na(+)/H(+) exchanger isoform 1Q28138314
Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocationQ28143472
Diversity of the mammalian sodium/proton exchanger SLC9 gene familyQ28185218
Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kDQ28236680
RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activityQ28258906
Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3Q28365699
A new sperm-specific Na+/H+ exchanger required for sperm motility and fertilityQ28506300
Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchangerQ28512455
Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenumQ28566267
Circadian regulation of electrolyte absorption in the rat colonQ28581734
Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3Q28609283
Characterization of the sodium/hydrogen exchanger NHA2Q28909807
Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivoQ28910193
A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertensionQ28910394
Na+/H+ Exchangers in Renal Regulation of Acid-Base BalanceQ28972309
COBALT: constraint-based alignment tool for multiple protein sequencesQ30014837
Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.Q30436136
Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertensionQ33665631
BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interactionQ39431004
A loss-of-function mutation in the SLC9A6 gene causes X-linked mental retardation resembling Angelman syndromeQ39495967
The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH.Q39498401
CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.Q39597237
Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8).Q40022256
Na+/H+ exchange and pH regulation in the control of neutrophil chemokinesis and chemotaxisQ40033025
NHE8 mediates amiloride-sensitive Na+/H+ exchange across mosquito Malpighian tubules and catalyzes Na+ and K+ transport in reconstituted proteoliposomesQ40173477
Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3.Q40184118
Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testisQ40253854
Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B.Q40567906
Differential regulation of Na+/H+ exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cellsQ40568292
Acute inhibition of brain-specific Na(+)/H(+) exchanger isoform 5 by protein kinases A and C and cell shrinkageQ40781766
Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.Q40845948
Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivationQ40899400
Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchangerQ41043721
Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice.Q41086785
Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domainsQ41129642
Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2)Q41548156
Membrane surface charge dictates the structure and function of the epithelial Na+/H+ exchangerQ41825284
Changes in mucosal homeostasis predispose NHE3 knockout mice to increased susceptibility to DSS-induced epithelial injuryQ41994420
The sodium/proton exchanger NHE8 regulates late endosomal morphology and functionQ42410551
Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa.Q42438913
D-Glucose Acts via Sodium/Glucose Cotransporter 1 to Increase NHE3 in Mouse Jejunal Brush Border by a Na+/H+ Exchange Regulatory Factor 2–Dependent ProcessQ42586814
Decreased NHE8 isoform expression and defective acidification in proximal convoluted tubules of senile ratsQ43177264
Preserved Na(+)/H(+) exchanger isoform 3 expression and localization, but decreased NHE3 function indicate regulatory sodium transport defect in ulcerative colitisQ43211963
Increased neuronal excitability and seizures in the Na(+)/H(+) exchanger null mutant mouseQ43666345
NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epitheliaQ43766328
Impact of sodium/proton exchanger 3 gene variants on sudden infant death syndromeQ43939359
Immunolocalization of NHE8 in rat kidneyQ45137007
Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failureQ46384565
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implicationsQ46915314
Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydricQ47658185
Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchangerQ47852356
Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger.Q48116251
Selective inhibition of the Na+/H+ exchanger type 3 activates CO2/H+-sensitive medullary neuronesQ48168683
NHE4 is critical for the renal handling of ammonia in rodentsQ33882811
Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea.Q33902827
Ontogeny of NHE8 in the rat proximal tubuleQ33989698
Effect of thyroid hormone on the postnatal renal expression of NHE8.Q34044085
Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functionsQ34155725
Transcriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5Q34212100
Nedd4-1 and β-Arrestin-1 Are Key Regulators of Na+/H+ Exchanger 1 Ubiquitylation, Endocytosis, and FunctionQ34352196
Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH.Q34430086
Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubuleQ34432837
Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1.Q34575006
Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathwayQ34597605
The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush borderQ34661729
Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulationQ34676624
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclastsQ34711561
NHE2X3 DKO mice exhibit gender-specific NHE8 compensationQ34783940
Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorderQ35054670
Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na⁺/H⁺ exchanger NHE5Q35083437
Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilliQ35266484
Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repairQ35516245
Endosomal Na+ (K+)/H+ exchanger Nhx1/Vps44 functions independently and downstream of multivesicular body formationQ35626230
A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC)Q35839579
Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexesQ35882115
Evolutionary origins of eukaryotic sodium/proton exchangersQ36005608
Molecular physiology of intestinal Na+/H+ exchangeQ36041041
Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.Q36342478
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndromeQ36718915
Regulatory binding partners and complexes of NHE3.Q36872214
Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrheaQ37064596
Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretionQ37379322
NhaA crystal structure: functional-structural insightsQ37485456
NHE3 regulatory complexesQ37485479
Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calciumQ37524282
Ammonium transport in the kidney.Q37822342
Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1.Q38295734
P433issue2-3
P407language of work or nameEnglishQ1860
P304page(s)236-251
P577publication date2013-04-01
P1433published inMolecular Aspects of MedicineQ6895933
P1476titleSLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers
P478volume34

Reverse relations

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