The biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3

scientific article published on 09 August 2013

The biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.12-225466
P932PMC publication ID3804747
P698PubMed publication ID23934281
P5875ResearchGate publication ID255735492

P2093author name stringKomal Vadnagara
Francesca Di Sole
Victor Babich
P2860cites workCalcineurin homologous protein as an essential cofactor for Na+/H+ exchangersQ24291225
Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elementsQ24318715
Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoformQ24321413
Diversity of the mammalian sodium/proton exchanger SLC9 gene familyQ28185218
Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchangerQ28591899
Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-)Q28941777
Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factorsQ33762974
Na+/H+ exchangers: physiology and link to hypertension and organ ischemiaQ33818226
Acute regulation of renal Na+/H+ exchanger NHE3 by dopamine: role of protein phosphatase 2A.Q33840532
Luminal Na(+)/H (+) exchange in the proximal tubuleQ33884278
Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1.Q34575006
Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulationQ34676624
Multiple modes of regulation of Na+/H+ exchangers.Q35034509
Molecular mechanisms of acid-base sensing by the kidneyQ35917532
Evolutionary origins of eukaryotic sodium/proton exchangersQ36005608
Molecular physiology of intestinal Na+/H+ exchangeQ36041041
Calcineurin homologous protein: a multifunctional Ca2+-binding protein familyQ36114956
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.Q36263013
N-myristoylation and Ca2+ binding of calcineurin B homologous protein CHP3 are required to enhance Na+/H+ exchanger NHE1 half-life and activity at the plasma membraneQ36347689
Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methodsQ36672564
Intracellular pH sensors: design principles and functional significanceQ36731993
Ca-dependent nonsecretory vesicle fusion in a secretory cellQ36741180
Regulatory binding partners and complexes of NHE3.Q36872214
The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing"Q36901232
Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer coupling models with 2Na/2H stoichiometryQ36908946
SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangersQ37047843
The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylationQ37297700
NHE3 regulatory complexesQ37485479
Deciphering the mechanisms of the Na+/H+ exchanger-3 regulation in organ dysfunction.Q37998392
Acute regulation of Na/H exchanger NHE3 by adenosine A(1) receptors is mediated by calcineurin homologous proteinQ40624365
Two histidine residues in the juxta-membrane cytoplasmic domain of Na+/H+ exchanger isoform 3 (NHE3) determine the set pointQ40676841
Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylationQ40809383
Regulation of NHE3 activity by G protein subunits in renal brush-border membranes.Q40889016
Adenosine inhibits the transfected Na+-H+ exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1).Q40969026
Giant membrane patches: improvements and applicationsQ41015149
Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domainsQ41129642
Parathyroid Hormone and Parathyroid Hormone-related Peptide Inhibit the Apical Na+/H+ Exchanger NHE-3 Isoform in Renal Cells (OK) via a Dual Signaling Cascade Involving Protein Kinase A and CQ41308389
Na/H exchange activities in NHE1-transfected OK-cells: cell polarity and regulationQ41523583
Parathyroid hormone regulation of Na+/H+ exchange in opossum kidney cells: polarity and mechanismsQ41726357
Regulation of Na+/H+ exchange in opossum kidney cells by parathyroid hormone, cyclic AMP and phorbol estersQ41753113
Impaired cell volume regulation in Na(+)-H+ exchange-deficient mutantsQ41759980
Ion fluxes in giant excised cardiac membrane patches detected and quantified with ion-selective microelectrodesQ41808783
Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domains.Q41888749
Gbeta regulation of Na/H exchanger-3 activity in rat renal proximal tubules during developmentQ42486083
Characterization of acute inhibition of Na/H exchanger NHE-3 by dopamine in opossum kidney cellsQ43514427
Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubilityQ43558559
Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.Q44132304
Bimodal acute effects of A1 adenosine receptor activation on Na+/H+ exchanger 3 in opossum kidney cellsQ44486181
Kinetic dissection of two distinct proton binding sites in Na+/H+ exchangers by measurement of reverse mode reactionQ44556038
Dysregulated pH: a perfect storm for cancer progression.Q45255109
Structural characterization of calcineurin B homologous protein 1.Q55040996
Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesiclesQ59070247
Distinct structural domains confer cAMP sensitivity and ATP dependence to the Na+/H+ exchanger NHE3 isoformQ71081834
Mutation of calmodulin-binding site renders the Na+/H+ exchanger (NHE1) highly H(+)-sensitive and Ca2+ regulation-defectiveQ72403727
Characterization of a histidine rich cluster of amino acids in the cytoplasmic domain of the Na+/H+ exchangerQ73233402
Dopamine(1) receptor, G(salpha), and Na(+)-H(+) exchanger interactions in the kidney in hypertensionQ74316950
Loss of calcineurin homologous protein-1 in chicken B lymphoma DT40 cells destabilizes Na+/H+ exchanger isoform-1 proteinQ80057945
NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activityQ80099460
Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failureQ82228645
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)4646-4658
P577publication date2013-08-09
P1433published inFASEB JournalQ520194
P1476titleThe biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3
P478volume27

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cites work (P2860)
Q50010141Application of Electrophysiology Measurement to Study the Activity of Electro-Neutral Transporters
Q40328966Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans
Q40902972Dual Effect of Adenosine A1 Receptor Activation on Renal O2 Consumption
Q38979089Novel developments in differentiating the role of renal and intestinal sodium hydrogen exchanger 3.
Q38727458Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease
Q27314340The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.
Q35652619The Na+/H+ Exchanger-3 (NHE3) Activity Requires Ezrin Binding to Phosphoinositide and Its Phosphorylation

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