Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease

scientific article published on January 2016

Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease is …
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P356DOI10.1007/978-3-319-21756-7_12
P698PubMed publication ID26860308

P50authorMeytal LandauQ28037100
P2093author name stringEtana Padan
P2860cites workThe epithelial sodium-hydrogen antiporter Na+/H+ exchanger 3 accumulates and is functional in recycling endosomesQ74088762
Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubuleQ74599385
Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic miceQ77975263
A pH-dependent conformational change of NhaA Na(+)/H(+) antiporter of Escherichia coli involves loop VIII-IX, plays a role in the pH response of the protein, and is maintained by the pure protein in dodecyl maltosideQ78151377
Ouabain inhibits tubuloglomerular feedback in mutant mice with ouabain-sensitive alpha1 Na,K-ATPaseQ79999464
Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of AktQ80148220
Structural biology. (Pseudo-)symmetrical transportQ85954834
Cytoplasmic pH, a key determinant of growth factor-induced DNA synthesis in quiescent fibroblastsQ93614908
Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brainQ22001480
Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi networkQ24291060
NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cellQ24291821
Structural and functional analysis of the transmembrane segment pair VI and VII of the NHE1 isoform of the Na+/H+ exchangerQ24297913
Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7Q24300303
Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporterQ24306376
Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulationQ24310771
Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)Q24314316
IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calciumQ24317729
A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchangeQ24318471
Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elementsQ24318715
Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit developmentQ24336124
Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophyQ24338075
beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoformQ24556620
A map of human genome variation from population-scale sequencingQ24617794
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorderQ24644291
Identifying autism loci and genes by tracing recent shared ancestryQ24655308
The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cellsQ24795765
Physiology of na+/h+ exchangers in the male reproductive tract: relevance for male fertilityQ26852460
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporterQ27643578
Conformations of NhaA, the Na/H exchanger from Escherichia coli, in the pH-activated and ion-translocating statesQ27653379
Transport mechanism of a bacterial homologue of glutamate transporters.Q27658257
Structural and Functional Analysis of Transmembrane Segment VI of the NHE1 Isoform of the Na+/H+ ExchangerQ27664496
Structure of Human Na+/H+ Exchanger NHE1 Regulatory Region in Complex with Calmodulin and Ca2+Q27674259
Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBTQ27674756
Binding thermodynamics of a glutamate transporter homologQ27677232
A two-domain elevator mechanism for sodium/proton antiportQ27679843
Structural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1.Q34452689
Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implicationsQ34479637
The changing face of the Na+/H+ exchanger, NHE1: structure, regulation, and cellular actionsQ34504091
Roles of NhaA, NhaB, and NhaD Na+/H+ antiporters in survival of Vibrio cholerae in a saline environmentQ34514641
Crucial steps in the structure determination of the Na+/H+ antiporter NhaA in its native conformationQ34558712
Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1.Q34575006
Characterization of a Na+/H+ antiporter gene of Escherichia coliQ34616491
Mechanism of Na+/H+ antiporting.Q34661701
The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush borderQ34661729
Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulationQ34676624
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclastsQ34711561
Alkaline pH homeostasis in bacteria: new insightsQ34772638
SSM-based electrophysiologyQ34803581
Ion selectivity in channels and transportersQ34865633
Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in familiesQ34895403
Transmembrane segment II of NhaA Na+/H+ antiporter lines the cation passage, and Asp65 is critical for pH activation of the antiporterQ35013536
Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform 1, in an experimental model of cardiopulmonary bypassQ35047112
Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorderQ35054670
Regulation of dendritic spine growth through activity-dependent recruitment of the brain-enriched Na⁺/H⁺ exchanger NHE5Q35083437
Role of the cardiac Na+/H+ exchanger during ischemia and reperfusionQ35090058
An overview of inhibitors of Na(+)/H(+) exchangerQ35165408
Acidification and protein trafficQ35200859
Functional analysis of the Na+,K+/H+ antiporter PeNHX3 from the tree halophyte Populus euphratica in yeast by model-guided mutagenesisQ35219636
Site-directed tryptophan fluorescence reveals two essential conformational changes in the Na+/H+ antiporter NhaA.Q35229161
Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilliQ35266484
X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction.Q35540083
Endosomal Na+ (K+)/H+ exchanger Nhx1/Vps44 functions independently and downstream of multivesicular body formationQ35626230
High capacity Na+/H+ exchange activity in mineralizing osteoblastsQ35690907
A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC)Q35839579
NhaA of Escherichia coli, as a model of a pH-regulated Na+/H+antiporterQ35849739
A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohortQ35854717
Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchangerQ35947311
Evolutionary origins of eukaryotic sodium/proton exchangersQ36005608
Molecular physiology of intestinal Na+/H+ exchangeQ36041041
Arginine oscillation explains Na+ independence in the substrate/product antiporter CaiTQ27680182
Structural basis of the alternating-access mechanism in a bile acid transporterQ27680833
Crystallographic evidence for the action of potassium, thallium, and lithium ions on fructose-1,6-bisphosphataseQ27729690
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle traffickingQ27936889
A novel topology model of the human Na(+)/H(+) exchanger isoform 1Q28138314
Diversity of the mammalian sodium/proton exchanger SLC9 gene familyQ28185218
Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeletonQ28219753
Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kDQ28236680
The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domainQ28246948
Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignmentsQ28258370
RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activityQ28258906
Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavageQ28278245
Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brainQ28296488
Role of the ubiquitin system in regulating ion transportQ28296575
Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1Q28301884
Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3Q28365699
Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiationQ28505241
A new sperm-specific Na+/H+ exchanger required for sperm motility and fertilityQ28506300
Impaired gastric acid secretion in mice with a targeted disruption of the NHE4 Na+/H+ exchangerQ28512455
Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenumQ28566267
NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected]Q28589589
Characterization of the sodium/hydrogen exchanger NHA2Q28909807
Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivoQ28910193
Sodium/hydrogen exchanger NHA2 is critical for insulin secretion in β-cellsQ28910221
A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertensionQ28910394
Family-based genome-wide association scan of attention-deficit/hyperactivity disorderQ28943341
Na+/H+ Exchangers in Renal Regulation of Acid-Base BalanceQ28972309
Intact Functional Fourteen-subunit Respiratory Membrane-bound [NiFe]-Hydrogenase Complex of the Hyperthermophilic ArchaeonPyrococcus furiosusQ29032075
Methanococcus jannaschii sp. nov., an extremely thermophilic methanogen from a submarine hydrothermal ventQ29039075
Animal plasma membrane energization by proton-motive V-ATPasesQ29540652
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transportersQ29616590
Structure of a glutamate transporter homologue from Pyrococcus horikoshiiQ30032687
Discontinuous membrane helices in transport proteins and their correlation with functionQ30158032
Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testisQ40253854
Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.Q40346034
Structure-based functional study reveals multiple roles of transmembrane segment IX and loop VIII-IX in NhaA Na+/H+ antiporter of Escherichia coli at physiological pHQ40447278
Dimeric interaction between the cytoplasmic domains of the Na+/H+ exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitationQ40523371
Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B.Q40567906
Mutations of Arg440 and Gly455/Gly456 oppositely change pH sensing of Na+/H+ exchanger 1.Q40673458
Specific modulation of Kex2/furin family proteases by potassiumQ40744778
Second-site revertants of a low-sodium-affinity mutant of the Na+/H+ exchanger reveal the participation of TM4 into a highly constrained sodium-binding siteQ40812416
Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosomeQ40826327
Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH.Q40874589
Phosphoinositide 3-kinase is involved in the tumor-specific activation of human breast cancer cell Na(+)/H(+) exchange, motility, and invasion induced by serum deprivationQ40899400
Cell type-specific acquired protection from crystal adherence by renal tubule cells in cultureQ40960989
Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchangerQ41043721
Calmodulin-binding autoinhibitory domain controls "pH-sensing" in the Na+/H+ exchanger NHE1 through sequence-specific interactionQ41086762
Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice.Q41086785
Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domainsQ41129642
Characterization of the rat Na+/H+ exchanger isoform NHE4 and localization in rat hippocampusQ41153722
Molecular physiology of vertebrate Na+/H+ exchangersQ41336654
Protein dynamics and conformational transitions in allosteric proteinsQ41376670
Na+/H+ exchanger-2 is an O-linked but not an N-linked sialoglycoproteinQ41429693
Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependenceQ41521361
A cation counterflux supports lysosomal acidificationQ41572483
Characterization of the placental brush border membrane Na+/H+ exchanger: identification of thiol-dependent transitions in apparent molecular sizeQ41583256
Membrane surface charge dictates the structure and function of the epithelial Na+/H+ exchangerQ41825284
Multiple carbohydrate moieties on the Na+/H+ exchangerQ41832664
Assessing oligomerization of membrane proteins by four-pulse DEER: pH-dependent dimerization of NhaA Na+/H+ antiporter of E. coli.Q41867016
The influence of protonation states on the dynamics of the NhaA antiporter from Escherichia coliQ41874029
Structure and substrate ion binding in the sodium/proton antiporter PaNhaP.Q41883653
Transport mechanism and pH regulation of the Na+/H+ antiporter NhaA from Escherichia coli: an electrophysiological studyQ41979595
Differential effects of mutations on the transport properties of the Na+/H+ antiporter NhaA from Escherichia coliQ42067529
Proton/sodium ion antiport in Escherichia coliQ42147886
Proximal tubule specific knockout of the Na⁺/H⁺ exchanger NHE3: effects on bicarbonate absorption and ammonium excretionQ42155895
The sodium/proton exchanger NHE8 regulates late endosomal morphology and functionQ42410551
Genes for endosomal NHE6 and NHE9 are misregulated in autism brains.Q42433166
Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa.Q42438913
Identification of sites required for down-regulation of Na+/H+ exchanger NHE3 activity by cAMP-dependent protein kinase. phosphorylation-dependent and -independent mechanismsQ42446313
Structure of the archaeal Na+/H+ antiporter NhaP1 and functional role of transmembrane helix 1.Q42578051
D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent processQ42586814
Functional and structural interactions of the transmembrane domain X of NhaA, Na+/H+ antiporter of Escherichia coli, at physiological pH.Q42611414
pH-induced structural change in a sodium/proton antiporter from Methanococcus jannaschiiQ42737359
Benchmarking membrane protein detergent stability for improving throughput of high-resolution X-ray structuresQ42751651
Structural dynamics and regulation of the mammalian SLC9A family of Na⁺/H⁺ exchangersQ43524456
Oligomerization of NhaA, the Na+/H+ antiporter of Escherichia coli in the membrane and its functional and structural consequences.Q43547737
Defective fluid secretion and NaCl absorption in the parotid glands of Na+/H+ exchanger-deficient miceQ43612393
Trans membrane domain IV is involved in ion transport activity and pH regulation of the NhaA-Na(+)/H(+) antiporter of Escherichia coliQ43847621
Conserved arginine and aspartate residues are critical for function of MjNhaP1, a Na+/H+ antiporter of M. jannaschiiQ44428888
Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435.Q44480855
Kinetic dissection of two distinct proton binding sites in Na+/H+ exchangers by measurement of reverse mode reactionQ44556038
Mice with a null mutation in the NHE1 Na+-H+ exchanger are resistant to cardiac ischemia-reperfusion injuryQ44582355
Mutation E252C Increases Drastically the K Value for Na+ and Causes an Alkaline Shift of the pH Dependence of NhaA Na+/H+ Antiporter of Escherichia coliQ44646965
Unraveling functional and structural interactions between transmembrane domains IV and XI of NhaA Na+/H+ antiporter of Escherichia coliQ44811170
Inhibition of the Na+/H+ exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbitsQ44974880
The fourth transmembrane domain of the Helicobacter pylori Na+/H+ antiporter NhaA faces a water-filled channel required for ion transport.Q44985710
Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestineQ45154807
2-Aminoperimidine, a specific inhibitor of bacterial NhaA Na(+)/H(+) antiportersQ45218376
Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress?Q46232820
Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failureQ46384565
Increased acyclovir oral bioavailability via a bile acid conjugateQ46439260
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.Q46745879
Dimeric structure of human Na+/H+ exchanger isoform 1 overproduced in Saccharomyces cerevisiae.Q46852370
Oligomeric structure of the carnitine transporter CaiT from Escherichia coliQ46859374
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implicationsQ46915314
NhaA crystal structure: functional-structural insightsQ37485456
NHE3 regulatory complexesQ37485479
Unlocking the molecular secrets of sodium-coupled transporters.Q37490830
The structural basis of secondary active transport mechanisms.Q37804492
Synapse development in health and disease.Q37833266
Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy.Q37987593
Structural and functional insights into the cardiac Na⁺/H⁺ exchangerQ38065640
Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer MetastasisQ38080049
NHE-1: still a viable therapeutic targetQ38083449
Common folds and transport mechanisms of secondary active transportersQ38105113
Traditional and emerging roles for the SLC9 Na+/H+ exchangersQ38171314
Functional and structural dynamics of NhaA, a prototype for Na(+) and H(+) antiporters, which are responsible for Na(+) and H(+) homeostasis in cellsQ38173211
Role of Na/H exchange in insulin secretion by islet cellsQ38212750
Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferationQ38263958
Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1.Q38295734
Kinetic properties of the plasma membrane Na+-H+ exchangerQ38393148
The intracellular Na(+)/H(+) exchanger NHE7 effects a Na(+)-coupled, but not K(+)-coupled proton-loading mechanism in endocytosisQ39001172
BetaPix up-regulates Na+/H+ exchanger 3 through a Shank2-mediated protein-protein interactionQ39431004
A loss-of-function mutation in the SLC9A6 gene causes X-linked mental retardation resembling Angelman syndromeQ39495967
The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH.Q39498401
The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 traffickingQ39572445
CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis.Q39597237
Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks.Q39911979
High-resolution structure of a Na+/H+ antiporter dimer obtained by pulsed electron paramagnetic resonance distance measurementsQ39939476
The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell linesQ39943810
Keeping it simple, transport mechanism and pH regulation in Na+/H+ exchangers.Q39999346
Gastrointestinal distribution and kinetic characterization of the sodium-hydrogen exchanger isoform 8 (NHE8).Q40022256
Dynamin is functionally coupled to insulin granule exocytosisQ40082346
A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogensQ40098154
Functional importance of charged residues within the putative intracellular loops in pH regulation by Na+/ H+ exchanger NHE1.Q40100915
Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3.Q40184118
Dimerization is crucial for the function of the Na+/H+ exchanger NHE1.Q40214270
The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single natureQ36228788
The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorptionQ36275737
A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosisQ36302254
Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.Q36325558
Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.Q36342478
Physiology and pathophysiology of Na+/H+ exchange and Na+ -K+ -2Cl- cotransport in the heart, brain, and blood.Q36399226
Gap junctional conductance between pairs of ventricular myocytes is modulated synergistically by H+ and Ca++.Q36410564
Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cellsQ36412230
22Na+ fluxes in thymic lymphocytes. I. Na+/Na+ and Na+/H+ exchange through an amiloride-insensitive pathwayQ36433579
Bile acid reabsorption inhibitors (BARI): novel hypolipidemic drugsQ36447222
Energy transduction in the thermophilic anaerobic bacterium Clostridium fervidus is exclusively coupled to sodium ionsQ36502560
Structural and functional analysis of the Na+/H+ exchangerQ36702137
Physiological role and regulation of the Na+/H+ exchangerQ36706197
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndromeQ36718915
Mechanism for alternating access in neurotransmitter transportersQ36785076
Bile acid transport systems as pharmaceutical targetsQ36829267
Regulatory binding partners and complexes of NHE3.Q36872214
Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformationQ36895867
The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing"Q36901232
Physiology and pathophysiology of Na(+)/H(+) exchange isoform 1 in the central nervous systemQ36907374
Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer coupling models with 2Na/2H stoichiometryQ36908946
Molecular biology of the myocardial Na+/H+ exchangerQ37055845
Protons extruded by NHE1: digestive or glue?Q37105130
Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1Q37118714
Na+/H+ antiport is essential for Yersinia pestis virulenceQ37123748
Why did the NHE inhibitor clinical trials fail?Q37142208
Genome-wide association studies in ADHD.Q37175234
The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary ciliumQ37237906
The biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3Q37245963
Functional evaluation of autism-associated mutations in NHE9.Q37274127
Transport dynamics in a glutamate transporter homologue.Q37312799
Structure and function of the human Na+/H+ exchanger isoform 1.Q37323205
Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretionQ37379322
Site-directed alkylation of cysteine to test solvent accessibility of membrane proteinsQ37417814
Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insightsQ30268449
pH- and sodium-induced changes in a sodium/proton antiporter.Q30358419
Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.Q30436136
Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epitheliaQ30657941
NhaA Na+/H+ antiporter mutants that hardly react to the membrane potentialQ31155381
Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertensionQ33665631
The putative Na+/H+ antiporter of Vibrio cholerae, Vc-NhaP2, mediates the specific K+/H+ exchange in vivoQ33738180
The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart diseaseQ33758353
The Na+/H+ exchanger NHE6 in the endosomal recycling system is involved in the development of apical bile canalicular surface domains in HepG2 cellsQ33761526
An inside job: how endosomal Na(+)/H(+) exchangers link to autism and neurological diseaseQ33791880
The expanding family of eucaryotic Na(+)/H(+) exchangersQ33807152
A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau depositionQ33808422
Na+/H+ exchangers: physiology and link to hypertension and organ ischemiaQ33818226
Intracellular pH regulation of CA1 neurons in Na(+)/H(+) isoform 1 mutant miceQ33857998
Projection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 A resolutionQ33866894
NHE4 is critical for the renal handling of ammonia in rodentsQ33882811
Luminal Na(+)/H (+) exchange in the proximal tubuleQ33884278
Three-dimensional structure of the ion-coupled transport protein NhaA.Q33886837
Na(+)/H(+) antiporters.Q33937928
Activation of AMP-activated protein kinase regulates hippocampal neuronal pH by recruiting Na(+)/H(+) exchanger NHE5 to the cell surfaceQ33947168
The transporter classification databaseQ34038896
The Proton Electrochemical Gradient in Escherichia coli CellsQ34051990
Single-molecule dynamics of gating in a neurotransmitter transporter homologueQ34130830
Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiaeQ34131430
Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functionsQ34155725
An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssiQ34182074
SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorderQ34209828
Helix VIII of NhaA Na(+)/H(+) antiporter participates in the periplasmic cation passage and pH regulation of the antiporterQ34215202
Acetylcholine receptor channel structure probed in cysteine-substitution mutants.Q34250941
A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changesQ34262440
The conserved nhaAR operon is drastically divergent between B2 and non-B2 Escherichia coli and is involved in extra-intestinal virulenceQ34277589
Unconventional chemiosmotic coupling of NHA2, a mammalian Na+/H+ antiporter, to a plasma membrane H+ gradientQ34297529
Regulation of the cardiac Na⁺/H⁺ exchanger in health and diseaseQ34328953
Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and functionQ34352196
Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH.Q34430086
Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubuleQ34432837
Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchangerQ47852356
Selective inhibition of the Na+/H+ exchanger type 3 activates CO2/H+-sensitive medullary neuronesQ48168683
Na+ channel expression and neuronal function in the Na+/H+ exchanger 1 null mutant mouse.Q48411517
Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.Q49088255
Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9.Q50461676
Monomers of the NhaA Na+/H+ antiporter of Escherichia coli are fully functional yet dimers are beneficial under extreme stress conditions at alkaline pH in the presence of Na+ or Li+.Q50467116
Report on the Na+/H+ Exchanger Satellite Meeting at the 53rd Annual Meeting of the Canadian Society of Biochemistry, Molecular and Cellular Biology.Q51043500
Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes.Q51367888
Na+/H+ exchanger 1 is regulated via its lipid-interacting domain, which functions as a molecular switch: a pharmacological approach using indolocarbazole compounds.Q51751484
A microdeletion in Xp11.3 accounts for co-segregation of retinitis pigmentosa and mental retardation in a large kindred.Q51922234
Intracellular sequestration of sodium by a novel Na+/H+ exchanger in yeast is enhanced by mutations in the plasma membrane H+-ATPase. Insights into mechanisms of sodium tolerance.Q52527519
Identification and biochemical characterization of the SLC9A7 interactome.Q52588312
Evidence that Na+/H+ exchanger 1 is an ATP-binding protein.Q52749646
The unwound portion dividing helix IV of NhaA undergoes a conformational change at physiological pH and lines the cation passage.Q53135546
Effect of mutations affecting Na+: H+ antiport activity on tumorigenic potential of hamster lung fibroblasts.Q53523434
The C-terminal cytoplasmic portion of the NhaP2 cation-proton antiporter from Vibrio cholerae affects its activity and substrate affinity.Q54298605
Conformational changes in NhaA Na+/H+ antiporter.Q54334524
Functional characterization of a NapA Na(+)/H(+) antiporter from Thermus thermophilus.Q54447880
Kinetics of charge translocation in the passive downhill uptake mode of the Na+/H+ antiporter NhaA of Escherichia coli.Q54479740
Identification of a pH regulated Na(+)/H(+) antiporter of Methanococcus jannaschii.Q54538491
ConSurf: Using Evolutionary Data to Raise Testable Hypotheses about Protein FunctionQ56879918
Congenital sodium diarrhea is an autosomal recessive disorder of sodium/proton exchange but unrelated to known candidate genesQ57637037
The Monoclonal Antibody 1F6 Identifies a pH-dependent Conformational Change in the Hydrophilic NH2Terminus of NhaA Na+/H+Antiporter ofEscherichia coliQ57828249
Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesiclesQ59070247
NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial spaceQ61642117
Conformational heterogeneity of the aspartate transporter GltPhQ62035571
Exocytosis-Endocytosis Coupling in the Pancreatic Beta CellQ69282297
Determination of the coupling ratio for Na+ -H+ exchange in renal microvillus membrane vesiclesQ70423104
Delineation of transmembrane domains of the Na+/H+ exchanger that confer sensitivity to pharmacological antagonistsQ71245955
pHi regulation in myocardium of the spontaneously hypertensive rat. Compensated enhanced activity of the Na(+)-H+ exchangerQ71807400
Regulation of cardiac Ca2+ release channel (ryanodine receptor) by Ca2+, H+, Mg2+, and adenine nucleotides under normal and simulated ischemic conditionsQ71834975
Histidine 225, a residue of the NhaA-Na+/H+ antiporter of Escherichia coli is exposed and faces the cell exteriorQ71985034
Heterologous expression of rat NHE4: a highly amiloride-resistant Na+/H+ exchanger isoformQ73085868
The epithelial Na(+)/H(+) exchanger, NHE3, is internalized through a clathrin-mediated pathwayQ73297480
A 90-kD Na(+)-H+ exchanger kinase has increased activity in spontaneously hypertensive rat vascular smooth muscle cellsQ73408679
Kinetic and pharmacological properties of human brain Na(+)/H(+) exchanger isoform 5 stably expressed in Chinese hamster ovary cellsQ73487362
Na+/H+ exchange in ischemia, reperfusion and preconditioningQ73858728
A biophysical study of integral membrane protein foldingQ73940353
P304page(s)391-458
P577publication date2016-01-01
P1433published inMetal ions in life sciencesQ26841945
P1476titleSodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and Disease
P478volume16

Reverse relations

cites work (P2860)
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