Alternative proton-binding site and long-distance coupling in Escherichia coli sodium-proton antiporter NhaA

scientific article published on 24 September 2020

Alternative proton-binding site and long-distance coupling in Escherichia coli sodium-proton antiporter NhaA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.2005467117
P932PMC publication ID7568328
P698PubMed publication ID32973095

P50authorOliver BecksteinQ30269624
Jana ShenQ87827774
Jack A HendersonQ91315645
Yandong HuangQ99710727
P2860cites workCanonical dynamics: Equilibrium phase-space distributionsQ21709091
An Implicit Membrane Generalized Born Theory for the Study of Structure, Stability, and Interactions of Membrane ProteinsQ24537724
CHARMM: the biomolecular simulation programQ24658108
A two-domain elevator mechanism for sodium/proton antiportQ27679843
Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiportersQ27703757
All-atom empirical potential for molecular modeling and dynamics studies of proteinsQ27860468
Continuous Constant pH Molecular Dynamics in Explicit Solvent with pH-Based Replica ExchangeQ29394790
Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulationsQ29547631
Update of the CHARMM all-atom additive force field for lipids: validation on six lipid typesQ29616710
Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insightsQ30268449
MMTSB Tool Set: enhanced sampling and multiscale modeling methods for applications in structural biology.Q30341299
Remeasuring HEWL pK(a) values by NMR spectroscopy: methods, analysis, accuracy, and implications for theoretical pK(a) calculationsQ30399241
Recent development and application of constant pH molecular dynamicsQ34300732
Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH.Q34430086
Evolutionary origins of eukaryotic sodium/proton exchangersQ36005608
Charge-leveling and proper treatment of long-range electrostatics in all-atom molecular dynamics at constant pH.Q36437502
Thermostat artifacts in replica exchange molecular dynamics simulationsQ37234757
Mechanism of pH-dependent activation of the sodium-proton antiporter NhaAQ37330506
Functional and structural dynamics of NhaA, a prototype for Na(+) and H(+) antiporters, which are responsible for Na(+) and H(+) homeostasis in cellsQ38173211
Sodium-Proton (Na(+)/H(+)) Antiporters: Properties and Roles in Health and DiseaseQ38727458
Lysine 300 is essential for stability but not for electrogenic transport of the Escherichia coli NhaA Na+/H+ antiporter.Q38885407
Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependenceQ41521361
Transport mechanism and pH regulation of the Na+/H+ antiporter NhaA from Escherichia coli: an electrophysiological studyQ41979595
Differential effects of mutations on the transport properties of the Na+/H+ antiporter NhaA from Escherichia coliQ42067529
Trans membrane domain IV is involved in ion transport activity and pH regulation of the NhaA-Na(+)/H(+) antiporter of Escherichia coliQ43847621
Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux PumpQ47154372
Asp133 residue in NhaA Na+/H+ antiporter is required for stabililty cation binding and transportQ50108134
Broad phylogenetic analysis of cation/proton antiporters reveals transport determinantsQ57476538
Replacement of Lys-300 with a glutamine in the NhaA Na/H antiporter of yields a functional electrogenic transporterQ58582436
Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shootingQ64114422
Overproduction and purification of a functional Na+/H+ antiporter coded by nhaA (ant) from Escherichia coliQ68238305
Essential aspartic acid residues, Asp-133, Asp-163 and Asp-164, in the transmembrane helices of a Na+/H+ antiporter (NhaA) from Escherichia coliQ72210118
Predicting Catalytic Proton Donors and Nucleophiles in Enzymes: How Adding Dynamics Helps Elucidate the Structure-Function RelationshipsQ87827776
Zooming in on a small multidrug transporter reveals details of asymmetric protonationQ90646398
GPU-Accelerated Implementation of Continuous Constant pH Molecular Dynamics in Amber: pKa Predictions with Single-pH SimulationsQ90987028
Ion Binding and Selectivity of the Na+/H+ Antiporter MjNhaP1 from Experiment and SimulationQ92005211
How Electrostatic Coupling Enables Conformational Plasticity in a Tyrosine KinaseQ93058867
P921main subjectEscherichia coliQ25419
P577publication date2020-09-24
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAlternative proton-binding site and long-distance coupling in Escherichia coli sodium-proton antiporter NhaA

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