Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.

scientific article published in September 2002

Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0014-2999(02)02193-3
P698PubMed publication ID12223226

P2093author name stringDelvin R Knight
Roger J Hill
Scott P Kennedy
W Ross Tracey
Janice A Brown
Roger B Ruggeri
Ronald T Wester
Jimmy X Kong
Ravi B Marala
Dexue Sun
Ernest S Hamanaka
P2860cites workMolecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2)Q24309159
Na+/H+ exchangers. Molecular diversity and relevance to heart.Q33692479
Hoe 694, a new Na+/H+ exchange inhibitor and its effects in cardiac ischaemiaQ36329610
Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusionQ36702426
Molecular physiology of vertebrate Na+/H+ exchangersQ41336654
Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubilityQ43558559
The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trialQ43796510
New Na(+)-H+ exchange inhibitor HOE 694 improves postischemic function and high-energy phosphate resynthesis and reduces Ca2+ overload in isolated perfused rabbit heartQ57189917
Na+-H+ exchange in isolated myocytes from adult rat heartQ69354423
Role of intracellular Na+ in Ca2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Possible involvement of H+-Na+ and Na+-Ca2+ exchangeQ69356843
Comparative Effects of Na+/H+ Exchange Inhibitors Against Cardiac Injury Produced by Ischemia/Reperfusion, Hypoxia/Reoxygenation, and the Calcium ParadoxQ72068282
Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) InvestigatorsQ73306456
(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitorsQ73477687
Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na(+)-H+ exchangeQ73709622
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)37-41
P577publication date2002-09-01
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleZoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.
P478volume451

Reverse relations

cites work (P2860)
Q37143512AMPA receptor pHluorin-GluA2 reports NMDA receptor-induced intracellular acidification in hippocampal neurons
Q44898182Adverse postresuscitation myocardial effects elicited by buffer-induced alkalemia ameliorated by NHE-1 inhibition in a rat model of ventricular fibrillation
Q30403680Amiloride and SN-6 suppress audiogenic seizure susceptibility in genetically epilepsy-prone rats
Q34672914Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion
Q46308399Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na+/H+ exchanger 1.
Q39200522Antiplatelet activity of drugs used in hypertension, dyslipidemia and diabetes: Additional benefit in cardiovascular diseases prevention.
Q46533714Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury
Q42922739Cardioprotective effects of the novel Na+/H+ exchanger-1 inhibitor KR-32560 in a perfused rat heart model of global ischemia and reperfusion: Involvement of the Akt-GSK-3β cell survival pathway and antioxidant enzyme
Q35047112Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform 1, in an experimental model of cardiopulmonary bypass
Q34583556Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation – the rat isolated working heart
Q39475053Cross-reactivity of acid-sensing ion channel and Na⁺-H⁺ exchanger antagonists with nicotinic acetylcholine receptors
Q39226084Effect of NSAIDs on Na⁺/H⁺ exchanger activity in rat colonic crypts.
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Q37245963The biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3
Q42172121The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms
Q61444189Tissue acidosis does not mediate the hypoxia selectivity of [Cu][Cu(ATSM)] in the isolated perfused rat heart
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Q37142208Why did the NHE inhibitor clinical trials fail?
Q34459460[Pt(O,O'-acac)(γ-acac)(DMS)] alters SH-SY5Y cell migration and invasion by the inhibition of Na+/H+ exchanger isoform 1 occurring through a PKC-ε/ERK/mTOR Pathway

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