Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility

scientific article

Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0960-894X(01)00059-2
P698PubMed publication ID11277524

P2093author name stringHill RJ
Allen MC
Brown JA
Tracey WR
Kennedy SP
Knight DR
Cook ER
Ruggeri RB
Kowalczyk PJ
Marala RB
Hamanaka ES
Day WW
Buchholz AR
Wester RT
Guzman-Perez A
Mularski CJ
Novomisle WA
P2860cites workNa+/H+ exchangers of mammalian cells.Q41581776
The Na-H exchanger revisited: an update on Na-H exchange regulation and the role of the exchanger in hypertension and cardiac function in health and diseaseQ41700674
Comparative molecular analysis of Na+/H+ exchangers: a unified model for Na+/H+ antiport?Q41736525
The myocardial sodium-hydrogen exchanger (NHE) and its role in mediating ischemic and reperfusion injury.Q47863154
(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitorsQ73477687
Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injuryQ77530047
GUARD During Ischemia Against Necrosis (GUARDIAN) trial in acute coronary syndromesQ78245339
Na+/H+ exchanger: proton modifier site regulation of activityQ33650017
The role of the myocardial sodium-hydrogen exchanger in mediating ischemic and reperfusion injury. From amiloride to cariporideQ33692467
Na+/H+ exchangers. Molecular diversity and relevance to heart.Q33692479
Functional and cellular regulation of the myocardial Na+/H+ exchangerQ33730443
Regulation of cardiac sarcolemmal Na+/H+ exchanger activity: potential pathophysiological significance of endogenous mediators and oxidant stressQ33730454
Mechanisms of protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibitionQ33730458
If ischemic preconditioning is the gold standard, has a platinum standard of cardioprotection arrived? Comparison with NHE inhibitionQ33730463
Protection of the myocardium with sodium-hydrogen exchange inhibitors: A cardiac surgical perspectiveQ33730472
Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemiaQ33730884
Sodium-hydrogen exchange inhibition: novel strategy to prevent myocardial injury following ischemia and reperfusionQ33730891
The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart diseaseQ33758353
The expanding family of eucaryotic Na(+)/H(+) exchangersQ33807152
Pharmacology and clinical assessment of cariporide for the treatment coronary artery diseasesQ34074858
Molecular physiology of vertebrate Na+/H+ exchangersQ41336654
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)803-807
P577publication date2001-03-01
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleDiscovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility
P478volume11

Reverse relations

cites work (P2860)
Q46308399Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na+/H+ exchanger 1.
Q44728606Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli
Q37304956Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research
Q50481301Catalyst-free, one-pot, three-component synthesis of 5-amino-1,3-aryl-₁Η-pyrazole-4-carbonitriles in green media.
Q46563940Chemoselective synthesis of substituted pyrazoles through AgOTf-catalyzed cascade propargylic substitution-cyclization-aromatization
Q58855703Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition
Q57771831Effects of KR-33028, a novel Na+/H+exchanger-1 inhibitor, on ischemia and reperfusion-induced myocardial infarction in rats and dogs
Q38068566Inside out: targeting NHE1 as an intracellular and extracellular regulator of cancer progression
Q51305174Interspecies variation in the metabolism of zoniporide by aldehyde oxidase.
Q35164744Is timing everything? Therapeutic potential of modulators of cardiac Na(+) transporters
Q93167009Isatin and its derivatives: a survey of recent syntheses, reactions, and applications
Q38184984Role of pHi, and proton transporters in oncogene-driven neoplastic transformation
Q36948618Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility
Q39068701Sodium hydrogen exchangers contribute to arenavirus cell entry
Q38354012Targeting osteopontin, the silent partner of Na+/H+ exchanger isoform 1 in cardiac remodeling
Q36769105The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury
Q37245963The biophysical and molecular basis of intracellular pH sensing by Na+/H+ exchanger-3
Q44132304Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.

Search more.