Role of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosis

scientific article published on 29 June 2016

Role of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SREP28911
P932PMC publication ID4926212
P698PubMed publication ID27354007

P2093author name stringYing Chen
Jie Chen
Chao Li
Xiaowei Lu
Dong Weng
Fangwei Liu
Wujing Dai
P2860cites workHuman CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells.Q53200046
Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells.Q53256514
Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.Q53957276
The carotenoid lutein enhances matrix metalloproteinase-9 production and phagocytosis through intracellular ROS generation and ERK1/2, p38 MAPK, and RARβ activation in murine macrophages.Q54448181
Type 2 immune response associated with silicosis is not instrumental in the development of the diseaseQ56834653
Experimental silicosis: a shift to a preferential IFN-gamma-based Th1 response in thoracic lymph nodesQ73843372
CD19 regulates the development of bleomycin-induced pulmonary fibrosis in a mouse modelQ79765352
CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivoQ80142486
What are regulatory B cells?Q82249253
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine modelQ83374824
CD19(+)CD1d(+)CD5(+) B cell frequencies are increased in patients with tuberculosis and suppress Th17 responsesQ83504166
Identifying Regulatory B Cells (B10 Cells) that Produce IL-10 in MiceQ85185765
Notes from the field: update: silicosis mortality - United States, 1999-2013Q24824097
IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosisQ28476584
Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cellsQ28732193
CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in miceQ33745170
Regulatory B cells play a key role in immune system balanceQ34033040
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patientsQ34093165
Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.Q34144779
Tregs promote the differentiation of Th17 cells in silica-induced lung fibrosis in miceQ34277943
Th17 can regulate silica-induced lung inflammation through an IL-1β-dependent mechanismQ34336840
Induction of IL-10-producing CD1dhighCD5+ regulatory B cells following Babesia microti-infectionQ34447223
Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg).Q34521067
Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4⁺ T cells to T-regulatory cellsQ34987934
Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 productionQ35016309
Regulatory B cells and allergic diseasesQ35062229
Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in miceQ35187089
Potent effects of dioscin against liver fibrosisQ35317884
Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice.Q35484992
Repeated exposure to Aspergillus fumigatus conidia results in CD4+ T cell-dependent and -independent pulmonary arterial remodeling in a mixed Th1/Th2/Th17 microenvironment that requires interleukin-4 (IL-4) and IL-10.Q35665448
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.Q36385029
In Vitro Induction of Allergen-Specific Interleukin-10-Producing Regulatory B Cell Responses by Interferon-γ in Non-Immunoglobulin E-Mediated Milk AllergyQ36485721
Deficiency of regulatory B cells increases allergic airway inflammationQ36497879
Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in miceQ36553694
Regulatory role of B cells in a murine model of allergic airway disease.Q36957781
Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesisQ37031308
The 'short' history of regulatory B cellsQ37090662
Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammationQ37176336
Regulatory B and T cells in infectionsQ37232197
Regulatory B cells as inhibitors of immune responses and inflammationQ37256986
IL-12 can alleviate Th17-mediated allergic lung inflammation through induction of pulmonary IL-10 expressionQ37276907
Reduction of IL-17A might suppress the Th1 response and promote the Th2 response by boosting the function of Treg cells during silica-induced inflammatory response in vitro.Q37622871
B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancerQ37690373
Effector and regulatory B cells: modulators of CD4+ T cell immunityQ37708012
Regulatory B cells in autoimmune diseasesQ37729359
A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosisQ37818921
IL-10 producing regulatory B cells in mice and humans: state of the art.Q37980170
CD4+ T lymphocytes in lung fibrosis: diverse subsets, diverse functionsQ38060461
IL-10 controls Th2-type cytokine production and eosinophil infiltration in a mouse model of allergic airway inflammationQ39604276
A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligandQ42568871
Regulatory B cells that produce IL-10: a breath of fresh air in allergic airway disease.Q42764563
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.Q42767100
IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosisQ43084852
Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice.Q44779559
Activation of CD4⁺ Foxp3⁺ regulatory T cells proceeds normally in the absence of B cells during EAE.Q47844479
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P304page(s)28911
P577publication date2016-06-29
P1433published inScientific ReportsQ2261792
P1476titleRole of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosis
P478volume6

Reverse relations

cites work (P2860)
Q47113769Association between nonspecific interstitial pneumonia and presence of CD20+ B lymphocytes within pulmonary lymphoid follicles.
Q38756261B lymphocytes in renal interstitial fibrosis
Q92135995B-1 Cells May Drive Macrophages Susceptibility to Trypanosoma cruzi Infection
Q47135902Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice
Q59795167Emerging Role of Immunosuppression in Diseases Induced by Micro- and Nano-Particles: Time to Revisit the Exclusive Inflammatory Scenario
Q33837257Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages
Q90307119Human monocytic myeloid-derived suppressor cells impair B-cell phenotype and function in vitro
Q41430983IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro.
Q37637477IL-10-Producing CD1dhiCD5+ Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients
Q39314792Immune monitoring as prerequisite for transplantation tolerance trials
Q57147435Involvement of Hookworm Co-Infection in the Pathogenesis and Progression of Podoconiosis: Possible Immunological Mechanism
Q52727564Killer (FASL regulatory) B cells are present during latent TB and are induced by BCG stimulation in participants with and without latent tuberculosis.
Q47772304Loss of regulatory characteristics in CD4+ CD25+/hi T cells induced by impaired transforming growth factor beta secretion in pneumoconiosis
Q90131716Lung Transplantation Has a Strong Impact on the Distribution and Phenotype of Monocyte Subsets
Q91620789N-acetylcysteine tiherapeutically protects against pulmonary fibrosis in a mouse model of silicosis
Q97067630Polarization of Immune Cells in the Pathologic Response to Inhaled Particulates
Q55241957Type 2 Immune Mechanisms in Carbon Nanotube-Induced Lung Fibrosis.
Q41221440miR-155 Regulates IL-10-Producing CD24hiCD27+ B Cells and Impairs Their Function in Patients with Crohn's Disease

Search more.