Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice

scientific article published on 26 September 2017

Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.7150/THNO.20270
P932PMC publication ID5695011
P698PubMed publication ID29158824

P2093author name stringYing Chen
Jie Chen
Chao Li
Yiping Lu
Siyi Li
Yiting Zhang
Dong Weng
Fangwei Liu
Sitong Du
P2860cites workCellular and molecular mechanisms of fibrosisQ24648892
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Differential activation of RAW 264.7 macrophages by size-segregated crystalline silicaQ28396563
Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in MiceQ29048610
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Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammationQ38721587
Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transitionQ38799932
Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathwayQ38922785
Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophagesQ39299592
Protective effects of dioscin against alcohol-induced liver injuryQ39328599
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Activated alveolar epithelial cells initiate fibrosis through secretion of mesenchymal proteinsQ41838448
CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary FibrosisQ41872888
Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survivalQ42115674
ASK1/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidneyQ42466844
Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 miceQ42711532
MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2.Q42806693
Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. WrightQ42957763
Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury.Q42965247
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Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibitionQ48280594
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Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanismsQ84762346
Fibrocytes contribute to inflammation and fibrosis in chronic hypersensitivity pneumonitis through paracrine effectsQ86373251
[Observation of the inflammatory factors level and the correlation between induced sputum and whole lung lavage fluid for silicosis]Q95361920
Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivoQ31088558
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repairQ33565774
CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in miceQ33745170
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory responseQ33853821
Macrophages: master regulators of inflammation and fibrosisQ34076279
Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in miceQ35064880
Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of sclerodermaQ35102837
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Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammationQ35230204
Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitisQ35230209
Potent effects of dioscin against liver fibrosisQ35317884
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transitionQ35641181
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiotaQ35671765
Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosisQ35750477
Smad3 as a mediator of the fibrotic responseQ35779047
Fibrotic disease and the T(H)1/T(H)2 paradigmQ35852270
Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosisQ36028616
Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis.Q36123039
Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathwayQ36361268
The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyondQ36493978
Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitmentQ36539561
Apoptosis signal-regulating kinase 1 in stress and immune responseQ36947070
Role of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosisQ37050039
Silicosis and silicotuberculosis in IndiaQ37298507
Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell linesQ37300056
Differential effect of grape seed extract against human non-small-cell lung cancer cells: the role of reactive oxygen species and apoptosis inductionQ37383943
CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytesQ37394389
The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosisQ37415507
ASK1 promotes the contact hypersensitivity response through IL-17 productionQ37705602
Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathwayQ37706853
CD4+ T lymphocytes in lung fibrosis: diverse subsets, diverse functionsQ38060461
The immunology of fibrosisQ38091697
Silica: a lung carcinogenQ38170330
Type 2 cytokines: mechanisms and therapeutic strategiesQ38424752
P433issue17
P921main subjectpulmonary fibrosisQ32446
P304page(s)4255-4275
P577publication date2017-09-26
P1433published inTheranosticsQ21051383
P1476titleDioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice
P478volume7

Reverse relations

cites work (P2860)
Q587544984-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in Mice
Q91790463Design, Preparation, and Characterization of Dioscin Nanosuspensions and Evaluation of Their Protective Effect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice
Q92402446Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3
Q64055129Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy
Q60937783Dioscin Inhibits Virulence Factors of
Q92617632Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway
Q91620789N-acetylcysteine tiherapeutically protects against pulmonary fibrosis in a mouse model of silicosis
Q90070027Recent Advances in the Pharmacological Activities of Dioscin
Q89638541Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex
Q92604926Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis
Q64065347The harmful effects of acute PM exposure to the heart and a novel preventive and therapeutic function of CEOs
Q92704496Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages

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