WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination

scientific article published on 17 April 2013

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPRENAL.00652.2012
P8608Fatcat IDrelease_tzqcjdyxoraczddnhojw6xh7aa
P932PMC publication ID3725674
P698PubMed publication ID23594824
P5875ResearchGate publication ID236224130

P50authorDouglas C EatonQ40752420
P2093author name stringLing Yu
Abdel A Alli
Hui Cai
Hui-Fang Bao
Otor Al-Khalili
Qian Yue
DeXuan Wang
P2860cites workPhosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expressionQ24534668
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family membersQ24633684
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathwayQ24648927
Characterization of the kinase activity of a WNK4 protein complexQ24658170
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasisQ24669948
Intersectin links WNK kinases to endocytosis of ROMK1Q24680263
Human hypertension caused by mutations in WNK kinasesQ28212182
Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cellsQ28213635
Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channelQ28240272
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunitsQ28249570
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndromeQ28288744
Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channelsQ28572912
WNK kinases regulate thiazide-sensitive Na-Cl cotransportQ28584824
Dietary Na+ inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y2-receptor tone.Q33868725
WNK1 activates SGK1 to regulate the epithelial sodium channel.Q33900653
RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporterQ34085234
Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathwaysQ34155287
Internalization of UT-A1 urea transporter is dynamin dependent and mediated by both caveolae- and clathrin-coated pit pathwaysQ34426294
WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cellsQ34524228
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.Q34711250
WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism.Q35159554
WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.Q35651892
WNK kinases: molecular regulators of integrated epithelial ion transportQ35858400
Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent processQ35974133
Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switchQ36088720
Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel poolQ36412575
Recycling of proteins between the endoplasmic reticulum and Golgi complexQ36457800
Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channelQ36749273
Multigene kinase network, kidney transport, and salt in essential hypertensionQ36862737
Regulation of the epithelial sodium channel by phosphatidylinositides: experiments, implications, and speculationsQ36866990
Regulation of a third conserved phosphorylation site in SGK1Q37081895
Physiologic regulation of the epithelial sodium channel by phosphatidylinositidesQ37241597
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interactionQ37258483
Mechanisms of Type I and Type II PseudohypoaldosteronismQ37786859
Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchangerQ39318132
The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical poolQ40112756
Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC.Q40133019
Spontaneous autocrine release of protons activates ASIC-mediated currents in HEK293 cellsQ40143880
Effect of divalent heavy metals on epithelial Na+ channels in A6 cellsQ40146587
Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cellsQ40441541
Distinct pools of epithelial sodium channels are expressed at the plasma membraneQ40507820
Epithelial sodium channels are activated by furin-dependent proteolysisQ40581030
Carboxylmethylation of the beta subunit of xENaC regulates channel activityQ41000456
Brefeldin A inhibition of apical Na+ channels in epitheliaQ41250182
Epithelial sodium channels: function, structure, and regulationQ41441322
Differential effects of brefeldin A on hormonally regulated Na+ transport in a model renal epithelial cell lineQ41480049
Effects of vasopressin and cAMP on single amiloride-blockable Na channelsQ41685903
Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activationQ41889980
Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4.Q42479166
Beta-adrenergic regulation of amiloride-sensitive lung sodium channelsQ43906827
Na+/H+ exchanger activity in the pig kidney epithelial cell line, LLC-PK1: inhibition by amiloride and its derivativesQ45275475
Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressureQ46146557
Aldosterone responsiveness of the epithelial sodium channel (ENaC) in colon is increased in a mouse model for Liddle's syndrome.Q46897768
Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibitionQ48792396
Mutational analysis of cysteine-rich domains of the epithelium sodium channel (ENaC). Identification of cysteines essential for channel expression at the cell surfaceQ48925095
Heteromeric assembly of acid-sensitive ion channel and epithelial sodium channel subunits.Q51796309
Reconstituted amiloride-inhibited sodium transporter from rabbit kidney medulla is responsible for Na+-H+ exchangeQ70189773
Mineralocorticoid regulation of epithelial Na+ channels is maintained in a mouse model of Liddle's syndromeQ73234623
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubuleQ80238253
P433issue1
P921main subjectprotein ubiquitinationQ3547638
P304page(s)F31-41
P577publication date2013-04-17
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleWNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination
P478volume305

Reverse relations

cites work (P2860)
Q37260675Aldosterone Upregulates Transient Receptor Potential Melastatin 7 (TRPM7).
Q49911717Aldosterone, SGK1, and ion channels in the kidney.
Q51102148Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC.
Q36017597Calmodulin and CaMKII modulate ENaC activity by regulating the association of MARCKS and the cytoskeleton with the apical membrane
Q38307745Dietary potassium and the renal control of salt balance and blood pressure
Q38987679Distinct action of flavonoids, myricetin and quercetin, on epithelial Cl⁻ secretion: useful tools as regulators of Cl⁻ secretion
Q34276479ENaC activity and expression is decreased in the lungs of protein kinase C-α knockout mice
Q37575563ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Cα knockout mice
Q51076939ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.
Q39415845Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.
Q39155176Regulation of Transporters and Channels by Membrane-Trafficking Complexes in Epithelial Cells
Q26770258Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity
Q38230038The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters
Q61811751Upregulation of the WNK4 Signaling Pathway Inhibits Epithelial Sodium Channels of Mouse Tracheal Epithelial Cells After Influenza A Infection
Q37694287WNK signalling pathways in blood pressure regulation

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