| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Ian Martin | |
| P2860 | cites work | Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease | Q22242985 |
| A novel protein with RNA-binding motifs interacts with ataxin-2 | Q22254111 | ||
| Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity | Q22254785 | ||
| The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity | Q24293505 | ||
| Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression | Q24293587 | ||
| Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP | Q24293723 | ||
| Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease | Q24294458 | ||
| Ataxin-2 and its Drosophila homolog, ATX2, physically assemble with polyribosomes | Q24296835 | ||
| Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS | Q24297462 | ||
| The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity | Q24297634 | ||
| LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis | Q24299176 | ||
| LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status | Q24300605 | ||
| Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules | Q24301077 | ||
| Kinase activity of mutant LRRK2 mediates neuronal toxicity | Q24303603 | ||
| GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2 | Q24306167 | ||
| RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways | Q24313263 | ||
| RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk | Q24315688 | ||
| Interplay of LRRK2 with chaperone-mediated autophagy | Q24322747 | ||
| Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death | Q24323228 | ||
| Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease | Q24336432 | ||
| Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia | Q24337840 | ||
| Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity | Q24338647 | ||
| Sustained translational repression by eIF2α-P mediates prion neurodegeneration | Q24602153 | ||
| Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS | Q24608159 | ||
| Aging as an event of proteostasis collapse | Q24630961 | ||
| Genome-wide association study reveals genetic risk underlying Parkinson's disease | Q24646654 | ||
| LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model | Q24656256 | ||
| The neurology of mTOR | Q26824286 | ||
| Principles of translational control: an overview | Q26995200 | ||
| Spreading of pathology in neurodegenerative diseases: a focus on human studies | Q28082279 | ||
| Regulation of translation initiation in eukaryotes: mechanisms and biological targets | Q28111696 | ||
| Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein | Q28117589 | ||
| Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology | Q28131833 | ||
| Translation initiator EIF4G1 mutations in familial Parkinson disease | Q28247679 | ||
| Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease | Q28292932 | ||
| Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice | Q28300013 | ||
| 'Rejuvenation' protects neurons in mouse models of Parkinson's disease | Q28305585 | ||
| DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras | Q28305931 | ||
| Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1 | Q28510145 | ||
| Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration | Q28590188 | ||
| Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease | Q29614900 | ||
| Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study | Q29614953 | ||
| LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity | Q29615144 | ||
| Kinase activity is required for the toxic effects of mutant LRRK2/dardarin | Q29620478 | ||
| Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss | Q30547326 | ||
| The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation | Q33525587 | ||
| Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster | Q33769106 | ||
| With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging | Q33912952 | ||
| Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy | Q33920691 | ||
| Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease | Q34112588 | ||
| Cellular strategies of protein quality control | Q34199521 | ||
| The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration. | Q34202584 | ||
| Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations | Q34452296 | ||
| Non-ATG-initiated translation directed by microsatellite expansions | Q34471662 | ||
| Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders | Q34543709 | ||
| Profiling of Parkin-binding partners using tandem affinity purification | Q35045403 | ||
| Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities | Q35172817 | ||
| LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice | Q35288337 | ||
| Transcriptional responses to loss or gain of function of the leucine-rich repeat kinase 2 (LRRK2) gene uncover biological processes modulated by LRRK2 activity | Q35605204 | ||
| PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane. | Q35684286 | ||
| EIF4G1 mutations do not cause Parkinson's disease | Q35732432 | ||
| Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning | Q35771011 | ||
| Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases | Q35864966 | ||
| G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies | Q36143858 | ||
| Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease | Q36841500 | ||
| Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila | Q36891456 | ||
| Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2. | Q37079316 | ||
| RNA-mediated toxicity in neurodegenerative disease | Q37216891 | ||
| Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions | Q37225356 | ||
| Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease | Q37402225 | ||
| Genetic animal models of Parkinson's disease | Q37765030 | ||
| LRRK2 pathobiology in Parkinson's disease | Q38253871 | ||
| Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate | Q38300785 | ||
| The PI3K/AKT Pathway as a Target for Cancer Treatment | Q38608907 | ||
| DJ-1, a novel regulator of the tumor suppressor PTEN. | Q39129969 | ||
| Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation | Q41812724 | ||
| Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. | Q41818673 | ||
| CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome | Q42068973 | ||
| Neuropathology of Parkinson's disease with the R1441G mutation in LRRK2. | Q43280089 | ||
| A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity | Q45814006 | ||
| Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation | Q47835833 | ||
| Survey on the PABC recognition motif PAM2. | Q47994563 | ||
| Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations | Q48252778 | ||
| EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts | Q48256432 | ||
| Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays. | Q54781213 | ||
| Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation | Q57373779 | ||
| Linking the VPS35 and EIF4G1 pathways in Parkinson's disease | Q64760478 | ||
| Mutations in EIF4G1 are not a common cause of Parkinson's disease | Q86380884 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial 4.0 International | Q34179348 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Parkinson's disease | Q11085 |
| messenger RNA | Q188928 | ||
| protein biosynthesis | Q211935 | ||
| pathogenesis | Q372016 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 17-27 | |
| P577 | publication date | 2016-01-29 | |
| P1433 | published in | Journal of Parkinson's disease | Q26842319 |
| P1476 | title | Decoding Parkinson's Disease Pathogenesis: The Role of Deregulated mRNA Translation | |
| P478 | volume | 6 |
Search more.