An iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins

scientific article published on July 2013

An iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CHEMBIOL.2013.04.019
P932PMC publication ID3728708
P698PubMed publication ID23890005

P50authorChristopher T. WalshQ1086992
Kendall HoukQ6388913
Gonzalo Jiménez-OsésQ43178326
P2093author name stringYi Tang
Wei Jiang
Xue Gao
Moon Seok Choi
P2860cites workDevelopment of the Colle-Salvetti correlation-energy formula into a functional of the electron densityQ21708802
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Anthranilate-activating modules from fungal nonribosomal peptide assembly linesQ33787584
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicumQ34163017
Aminobenzoates as building blocks for natural product assembly linesQ34230699
The near attack conformation approach to the study of the chorismate to prephenate reactionQ34267037
Biosynthesis of nonribosomal peptides1.Q34359384
Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesisQ34425191
A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceusQ34564624
A view at the millennium: the efficiency of enzymatic catalysisQ34568401
Universal solvation model based on solute electron density and on a continuum model of the solvent defined by the bulk dielectric constant and atomic surface tensionsQ34975596
Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites.Q35058923
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.Q35355749
Cyclization of fungal nonribosomal peptides by a terminal condensation-like domainQ36420193
5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. I. Taxonomy and fermentation of the producing organism and biological activityQ36780974
Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocksQ37228644
Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.Q37229208
Use of solution-phase vibrational frequencies in continuum models for the free energy of solvationQ37923477
Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeeminQ39972234
Complete reconstitution of a highly reducing iterative polyketide synthaseQ40705862
Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin EQ41417291
Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigationQ46253077
Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases.Q51636993
An Evaluation of Harmonic Vibrational Frequency Scale FactorsQ58485371
Genomic mining for Aspergillus natural productsQ62658783
Novel cholecystokinin antagonists from Aspergillus alliaceus. II. Structure determination of asperlicins B, C, D, and EQ68506267
Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetasesQ74248709
5-N-Acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. I. Taxonomy and fermentation of the producing organism and biological activity.Q104985664
P433issue7
P304page(s)870-878
P577publication date2013-07-01
P1433published inChemistry and BiologyQ15758410
P1476titleAn iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins
P478volume20

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cites work (P2860)
Q27021412Biosynthesis of fungal indole alkaloids
Q56890015Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
Q35866989In Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic
Q28607124Metabolic Engineering of Pseudomonas putida KT2440 to Produce Anthranilate from Glucose
Q36316177Nonribosomal Peptide Synthesis-Principles and Prospects
Q48144026Traceless Solid-Phase Synthesis of Fused Chiral Macrocycles via Conformational Constraint-Assisted Cyclic Iminium Formation.

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