Human Immunodeficiency Virus Type 1 N-Terminal Capsid Mutants Containing Cores with Abnormally High Levels of Capsid Protein and Virtually No Reverse Transcriptase

scientific article published on December 1, 2003

Human Immunodeficiency Virus Type 1 N-Terminal Capsid Mutants Containing Cores with Abnormally High Levels of Capsid Protein and Virtually No Reverse Transcriptase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.77.23.12592-12602.2003
P953full work available at URLhttps://jvi.asm.org/content/jvi/77/23/12592.full.pdf
https://europepmc.org/articles/PMC262599
https://europepmc.org/articles/PMC262599?pdf=render
https://doi.org/10.1128/jvi.77.23.12592-12602.2003
https://journals.asm.org/doi/pdf/10.1128/JVI.77.23.12592-12602.2003
P932PMC publication ID262599
P698PubMed publication ID14610182

P50authorEric O FreedQ67208349
P2093author name stringNaiqian Cheng
Shixing Tang
Tsutomu Murakami
Alasdair C. Steven
Judith G. Levin
P2860cites workStructural insights into the catalytic mechanism of cyclophilin AQ24301154
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and compositionQ24673418
Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infectionQ24673913
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structuresQ26778412
Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyproteinQ27639039
Crystal structure of dimeric HIV-1 capsid proteinQ27733334
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsidQ27734262
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid proteinQ27746461
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infectionQ28646834
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular cloneQ29547734
Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and BQ29618922
Viral DNA synthesis defects in assembly-competent Rous sarcoma virus CA mutants.Q30327614
Cyclophilin A-induced alterations of human immunodeficiency virus type 1 CA protein in vitroQ30428149
Retrovirus capsid protein assembly arrangementsQ30873476
Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.Q33685950
Isolation of human immunodeficiency virus type 1 cores: retention of Vpr in the absence of p6(gag).Q33807166
Reversion of a human immunodeficiency virus type 1 matrix mutation affecting Gag membrane binding, endogenous reverse transcriptase activity, and virus infectivityQ33813747
Association of Nef with the human immunodeficiency virus type 1 coreQ33821376
Second-site suppressors of Rous sarcoma virus Ca mutations: evidence for interdomain interactionsQ33844210
Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cellsQ33845811
Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1.Q33851147
Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA.Q33852465
Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequencesQ33930053
Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin AQ34024214
Structural biology of HIV.Q34068223
Assembling the human immunodeficiency virus type 1.Q34148871
p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing proteaseQ34288376
Functional association of cyclophilin A with HIV-1 virionsQ34326356
Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replicationQ34364648
Treatment of human immunodeficiency virus type 1 virions depleted of cyclophilin A by natural endogenous reverse transcription restores infectivityQ34782333
Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity.Q35830898
Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix.Q35835956
Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcriptionQ35861172
The role of Gag in human immunodeficiency virus type 1 virion morphogenesis and early steps of the viral life cycleQ35873645
Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120.Q36632356
Functional domains of the capsid protein of human immunodeficiency virus type 1Q36638060
Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutantsQ36650299
Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex.Q36684088
A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivityQ36756570
The gag gene products of human immunodeficiency virus type 1: alignment within the gag open reading frame, identification of posttranslational modifications, and evidence for alternative gag precursorsQ36881276
Specific incorporation of cyclophilin A into HIV-1 virionsQ38302257
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.Q39579012
N-Terminal extension of human immunodeficiency virus capsid protein converts the in vitro assembly phenotype from tubular to spherical particlesQ39580545
Biochemical and structural analysis of isolated mature cores of human immunodeficiency virus type 1.Q39588178
Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein.Q39602742
Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complexQ39736736
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid ProteinQ39748566
Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.Q39880513
Effects of gag mutations on human immunodeficiency virus type 1 particle assembly, processing, and cyclophilin A incorporationQ40706744
In vitro assembly properties of wild-type and cyclophilin-binding defective human immunodeficiency virus capsid proteins in the presence and absence of cyclophilin A.Q40959792
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assemblyQ41047831
Amino acid substitutions in the CA protein of Moloney murine leukemia virus that block early events in infectionQ41174834
Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strainQ41299810
Identification of novel interactions in HIV-1 capsid protein assembly by high-resolution mass spectrometry.Q41629680
Image reconstructions of helical assemblies of the HIV-1 CA proteinQ41631451
HIV: early virus-cell interactionsQ41748918
Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interactionQ42554107
A conformational switch controlling HIV-1 morphogenesisQ42690194
HIV-1 gag proteins: diverse functions in the virus life cycleQ43783202
Antiviral inhibition of the HIV-1 capsid proteinQ44380725
Mutations within the human immunodeficiency virus type 1 gp160 envelope glycoprotein alter its intracellular transport and processingQ45252128
Characterization of a human immunodeficiency virus type 1 pre-integration complex in which the majority of the cDNA is resistant to DNase I digestionQ45730867
Cyclophilin A incorporation is not required for human immunodeficiency virus type 1 particle maturation and does not destabilize the mature capsidQ45749967
Generation of HIV-1/HIV-2 cross-reactive peptide antisera by small sequence changes in HIV-1 reverse transcriptase and integrase immunizing peptidesQ47789870
Assembly and analysis of conical models for the HIV-1 core.Q52228420
Form, function, and use of retroviral gag proteinsQ67961638
Assembly and morphology of HIV: potential effect of structure on viral functionQ68251795
Structure of the amino-terminal core domain of the HIV-1 capsid proteinQ71142552
Characterization of HIV replication complexes early after cell-to-cell infectionQ71602121
Molecular recognition in the HIV-1 capsid/cyclophilin A complexQ73511357
Proline residues in the HIV-1 NH2-terminal capsid domain: structure determinants for proper core assembly and subsequent steps of early replicationQ73514585
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectmicrobiologyQ7193
immunologyQ101929
P304page(s)12592-12602
P577publication date2003-12-01
P1433published inJournal of VirologyQ1251128
P1476titleHuman immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptase
Human Immunodeficiency Virus Type 1 N-Terminal Capsid Mutants Containing Cores with Abnormally High Levels of Capsid Protein and Virtually No Reverse Transcriptase
P478volume77

Reverse relations

cites work (P2860)
Q40176627A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA.
Q37780981A new functional role of HIV-1 integrase during uncoating of the viral core
Q35750243A second-site suppressor significantly improves the defective phenotype imposed by mutation of an aromatic residue in the N-terminal domain of the HIV-1 capsid protein
Q40311599A small loop in the capsid protein of Moloney murine leukemia virus controls assembly of spherical cores
Q42546287A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle
Q33755116ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity
Q36845921Capsid proteins from human immunodeficiency virus type 1 and simian immunodeficiency virus SIVmac can coassemble into mature cores of infectious viruses.
Q36424184Cell factors stimulate human immunodeficiency virus type 1 reverse transcription in vitro
Q90115233Characterization of HIV-1 uncoating in human microglial cell lines
Q45046883Characterization of a DNA vaccine expressing a human immunodeficiency virus-like particle
Q40092223Characterization of replication defects induced by mutations in the basic domain and C-terminus of HIV-1 matrix
Q38903364Complementary Assays Reveal a Low Level of CA Associated with Viral Complexes in the Nuclei of HIV-1-Infected Cells
Q36950909Contributions of Charged Residues in Structurally Dynamic Capsid Surface Loops to Rous Sarcoma Virus Assembly
Q40578149Effect of internal cleavage site mutations in human immunodeficiency virus type 1 capsid protein on its structure and function.
Q40074644Effects of rapid antigen degradation and VEE glycoprotein specificity on immune responses induced by a VEE replicon vaccine
Q27490926Focus on flaviviruses: current and future drug targets
Q56988804Forced Complementation between Subgenomic RNAs: Does Human Immunodeficiency Type 1 Virus Reverse Transcription Occur in Viral Core, Cytoplasm, or Early Endosome?
Q35635221Genetic Studies of the beta-hairpin loop of Rous sarcoma virus capsid protein.
Q37447762HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.
Q36702218HIV-1 matrix protein: a mysterious regulator of the viral life cycle
Q41690997Identification of capsid mutations that alter the rate of HIV-1 uncoating in infected cells
Q41956340Isolated HIV-1 core is active for reverse transcription.
Q45411655Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses than soluble envelopes
Q40326740Mutant murine leukemia virus Gag proteins lacking proline at the N-terminus of the capsid domain block infectivity in virions containing wild-type Gag.
Q43168272Mutation of critical serine residues in HIV-1 matrix result in an envelope incorporation defect which can be rescued by truncation of the gp41 cytoplasmic tail
Q40174170Mutational analysis of the N-terminal domain of Moloney murine leukemia virus capsid protein
Q36496940RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis.
Q44949244Resistance of monocyte to HIV-1 infection is not due to uncoating defect
Q34775658Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription
Q33826918Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core
Q34965309Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1
Q45394517Snake venom preparation for drug-resistant human immunodeficiency virus
Q55517077The KT Jeang Retrovirology prize 2018: Eric Freed.
Q37492757The conserved carboxy terminus of the capsid domain of human immunodeficiency virus type 1 gag protein is important for virion assembly and release
Q41849464The cyclosporin A washout assay to detect HIV-1 uncoating in infected cells
Q36614059The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability
Q45413360The matrix protein of human immunodeficiency virus is cleaved and packed into virion cores
Q36329001Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles
Q33718140Virus particle core defects caused by mutations in the human immunodeficiency virus capsid N-terminal domain

Search more.