A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle

scientific article published on 10 June 2009

A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00317-09
P932PMC publication ID2738153
P698PubMed publication ID19515760

P50authorRonald SwanstromQ62641484
P2093author name stringSook-Kyung Lee
Janera Harris
P2860cites workRole of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1Q24609814
Analysis of mutation in human cells by using an Epstein-Barr virus shuttle systemQ24628961
Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyproteinQ27639039
Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA ProteinQ27647971
Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle buddingQ28274359
Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotypeQ28646874
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.Q29619254
Viral DNA synthesis defects in assembly-competent Rous sarcoma virus CA mutants.Q30327614
Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in GagQ30478394
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral proteaseQ30850215
A peptide inhibitor of HIV-1 assembly in vitroQ33220259
Towards the structure of the human immunodeficiency virus: divide and conquerQ33632676
Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequencesQ33930053
HIV preferentially infects HIV-specific CD4+ T cellsQ33958893
The stoichiometry of Gag protein in HIV-1.Q34328141
Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replicationQ34364648
High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS.Q34420162
Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1Q36098898
Recombination of transfected DNAs in vertebrate cells in cultureQ36269941
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.Q36650046
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturationQ36944553
Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturationQ36958798
Human Immunodeficiency Virus Type 1 N-Terminal Capsid Mutants Containing Cores with Abnormally High Levels of Capsid Protein and Virtually No Reverse TranscriptaseQ37060306
PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processingQ37089562
Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activatorQ37256308
High-resolution structure of a retroviral capsid hexameric amino-terminal domainQ39272732
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.Q39579012
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid ProteinQ39748566
Comparison of trans-dominant inhibitory mutant human immunodeficiency virus type 1 genes expressed by retroviral vectors in human T lymphocytes.Q40045233
Lentiviral vector transduction of a dominant-negative Rev gene into human CD34+ hematopoietic progenitor cells potently inhibits human immunodeficiency virus-1 replicationQ40197225
Mutant murine leukemia virus Gag proteins lacking proline at the N-terminus of the capsid domain block infectivity in virions containing wild-type Gag.Q40326740
Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particlesQ40357793
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assemblyQ41047831
Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replicationQ41981808
Dominant negative inhibition of human immunodeficiency virus particle production by the nonmyristoylated form of gag.Q42688106
Inhibition of human immunodeficiency virus-1 (HIV-1) replication after transduction of granulocyte colony-stimulating factor-mobilized CD34+ cells from HIV-1-infected donors using retroviral vectors containing anti-HIV-1 genes.Q43698594
Antiviral inhibition of the HIV-1 capsid proteinQ44380725
Mutational analysis of HIV-1 Tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR-driven gene expressionQ44389543
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitorQ45432280
HIV-1 capsid mutants inhibit the replication of wild-type virus at both early and late infection phasesQ45759776
HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virusQ45843803
Inhibiting AIDS in the central nervous system: gene delivery to protect neurons from HIV.Q45862705
Trans-dominant inhibition of RNA viral replication can slow growth of drug-resistant virusesQ46555479
Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cellsQ46848734
Analysis of retroviral protease cleavage sites reveals two types of cleavage sites and the structural requirements of the P1 amino acidQ54693321
Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev functionQ58611466
Combination genetic therapy to inhibit HIV-1Q77474900
Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278)Q80280623
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)8536-8543
P577publication date2009-06-10
P1433published inJournal of VirologyQ1251128
P1476titleA strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle
P478volume83

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cites work (P2860)
Q41730903A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro
Q40618525A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny
Q42872702A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease
Q39214476A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells
Q34771244A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid
Q36292602ATP generation in a host cell in early-phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag.
Q27324263Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors
Q51740197An RNA-binding compound that stabilizes the HIV-1 gRNA packaging signal structure and specifically blocks HIV-1 RNA encapsidation.
Q41816646BST-2 Diminishes HIV-1 Infectivity
Q42001066Clearly different mechanisms of enhancement of short-lived Nef-mediated viral infectivity between SIV and HIV-1.
Q33761008Cryo electron tomography of native HIV-1 budding sites
Q34435796Development of a Novel Screening Strategy Designed to Discover a New Class of HIV Drugs
Q33791156Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity
Q92623235Dominant Negative MA-CA Fusion Protein Is Incorporated into HIV-1 Cores and Inhibits Nuclear Entry of Viral Preintegration Complexes
Q36434250Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain
Q34237075Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications
Q33990752Generation of infectious feline immunodeficiency virus (FIV) encoding FIV/human immunodeficiency virus chimeric protease
Q39226845Glyceraldehyde 3-phosphate dehydrogenase negatively regulates human immunodeficiency virus type 1 infection
Q24614498HIV type 1 Gag as a target for antiviral therapy
Q58597952HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Classes of Target Sites
Q38366763HIV-1 gag: an emerging target for antiretroviral therapy.
Q57050142High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation
Q57459053Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation
Q30832180In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway
Q41735307Induced maturation of human immunodeficiency virus.
Q36884128Integrating the HIV-1 assembly/maturation pathway
Q35477673Lentiviral Gag assembly analyzed through the functional characterization of chimeric simian immunodeficiency viruses expressing different domains of the feline immunodeficiency virus capsid protein
Q30613887Maturation of the HIV-1 core by a non-diffusional phase transition.
Q59357414Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis
Q33624690Novel approaches to inhibiting HIV-1 replication.
Q47109778Patterns of conserved gp120 epitope presentation on attached HIV-1 virions
Q41844750Protease-Mediated Maturation of HIV: Inhibitors of Protease and the Maturation Process
Q30049307Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant Hepatitis
Q40732172RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly
Q38393674Retroviral proteases and their roles in virion maturation
Q26752271Retrovirus maturation-an extraordinary structural transformation
Q92490664Second Generation Inhibitors of HIV-1 Maturation
Q36814171Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer
Q33769181Structural analysis of HIV-1 maturation using cryo-electron tomography
Q28828191Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396
Q35024116Targeting the HIV entry, assembly and release pathways for anti-HIV gene therapy
Q41682586The C-terminal domain of glyceraldehyde 3-phosphate dehydrogenase plays an important role in suppression of tRNALys3 packaging into human immunodeficiency virus type-1 particles
Q33919690The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.
Q33727091The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation
Q27009643The choreography of HIV-1 proteolytic processing and virion assembly
Q39621109Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacity
Q52339521Transmission genetics of drug-resistant hepatitis C virus.

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