Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation

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Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.01567-18
P953full work available at URLhttp://eprints.whiterose.ac.uk/136929
P932PMC publication ID6191540
P698PubMed publication ID30327442

P50authorJuan FontanaQ55189685
Lucas J AdamsQ56451770
Anna T GresQ57175635
Eric O FreedQ67208349
P2093author name stringStefan G Sarafianos
Alasdair C Steven
Ferri Soheilian
Muthukumar Balasubramaniam
Mariia Novikova
Dennis C Winkler
Sagar B Kudchodkar
P2860cites workRetrovirus maturation-an extraordinary structural transformationQ26752271
Virus budding and the ESCRT pathwayQ26828590
Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation InhibitorsQ27324263
Protease cleavage leads to formation of mature trimer interface in HIV-1 capsidQ27342743
Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle productionQ27485930
X-ray structures of the hexameric building block of the HIV capsidQ27655910
Atomic-level modelling of the HIV capsidQ27666657
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamicsQ27678383
Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA ProteinQ27678471
Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolutionQ27696126
The Mechanism of HIV-1 Core Assembly: Insights from Three-Dimensional Reconstructions of Authentic VirionsQ27702100
An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturationQ27719352
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid proteinQ27746461
XDSQ27860472
Coot: model-building tools for molecular graphicsQ27860505
Overview of the CCP4 suite and current developmentsQ27860782
REFMAC5 for the refinement of macromolecular crystal structuresQ27860905
PHENIX: building new software for automated crystallographic structure determinationQ27861044
Scaling and assessment of data qualityQ27861107
Structural and functional insights into the HIV-1 maturation inhibitor binding pocketQ28485054
The HIV mutation browser: a resource for human immunodeficiency virus mutagenesis and polymorphism dataQ28542469
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular cloneQ29547734
Automated electron microscope tomography using robust prediction of specimen movementsQ29616585
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.Q29622903
Crystal structure of an HIV assembly and maturation switch.Q30276365
STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.Q30279235
The structural biology of HIV assemblyQ30437103
Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shellsQ30479297
Maturation of the HIV-1 core by a non-diffusional phase transition.Q30613887
In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathwayQ30832180
How HIV-1 Gag assembles in cells: Putting together pieces of the puzzleQ33358839
The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturationQ33727091
The C-terminal half of the human immunodeficiency virus type 1 Gag precursor is sufficient for efficient particle assembly.Q33785479
Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.Q34131332
Structural changes in Influenza virus at low pH characterized by cryo-electron tomographyQ34132726
p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing proteaseQ34288376
HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag latticeQ34529834
Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restrictionQ34624282
Extreme genetic fragility of the HIV-1 capsid.Q34789351
Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.Q34984031
In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).Q35139703
Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice.Q35832693
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.Q36650046
Computational resources for cryo-electron tomography in Bsoft.Q36692815
In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivityQ36825840
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturationQ36944553
Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturationQ36958798
PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processingQ37089562
A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.Q37336728
HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.Q37447762
HIV-1 assembly, budding, and maturationQ38023864
In vitro assembly properties of purified bacterially expressed capsid proteins of human immunodeficiency virusQ38341673
HIV-1 assembly, release and maturation.Q38539565
Second site reversion of a mutation near the amino terminus of the HIV-1 capsid proteinQ39065469
A Consensus View of ESCRT-Mediated Human Immunodeficiency Virus Type 1 Abscission.Q39439244
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid ProteinQ39748566
The structure and flexibility of conical HIV-1 capsids determined within intact virionsQ40408064
Species-specific tropism determinants in the human immunodeficiency virus type 1 capsidQ40556428
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assemblyQ41047831
Image reconstructions of helical assemblies of the HIV-1 CA proteinQ41631451
A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycleQ42546287
Antiviral inhibition of the HIV-1 capsid proteinQ44380725
Quenching protein dynamics interferes with HIV capsid maturation.Q47107077
Susceptibility and adaptation to human TRIM5α alleles at positive selected sites in HIV-1 capsid.Q51059421
Assembly and analysis of conical models for the HIV-1 core.Q52228420
Noise Reduction in Electron Tomographic Reconstructions Using Nonlinear Anisotropic DiffusionQ58022775
P433issue5
P407language of work or nameEnglishQ1860
P577publication date2018-10-16
P1433published inmBioQ15817061
P1476titleIdentification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation
P478volume9

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cites work (P2860)
Q99557057Elucidating the basis for permissivity of the MT-4 T-cell line to replication of an HIV-1 mutant lacking the gp41 cytoplasmic tail
Q64247477Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle
Q92967377Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly

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