Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturation

scientific article published on 26 July 2008

Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2008.06.030
P932PMC publication ID2577075
P698PubMed publication ID18657842
P5875ResearchGate publication ID51430891

P50authorRoger G PtakQ90694284
William FuQ115679043
P2093author name stringVinay K Pathak
Wei-Shau Hu
Kunio Nagashima
Ferri Soheilian
Michael D Moore
P2860cites workActive human immunodeficiency virus protease is required for viral infectivityQ24647696
Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different ratesQ24812175
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionQ29547852
Viral dynamics in human immunodeficiency virus type 1 infectionQ29547908
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.Q29619254
Genetic recombination of human immunodeficiency virus type 1 in one round of viral replication: effects of genetic distance, target cells, accessory genes, and lack of high negative interference in crossover eventsQ33716831
Proteolytic processing of the p2/nucleocapsid cleavage site is critical for human immunodeficiency virus type 1 RNA dimer maturation.Q33845445
The late domain of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent mannerQ34104639
p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing proteaseQ34288376
Effects of Gag mutation and processing on retroviral dimeric RNA maturationQ34302140
The stoichiometry of Gag protein in HIV-1.Q34328141
The conformation of the mature dimeric human immunodeficiency virus type 1 RNA genome requires packaging of pol protein.Q34999802
Effects of blocking individual maturation cleavages in murine leukemia virus gag.Q35542805
Human immunodeficiency virus type 1 virions composed of unprocessed Gag and Gag-Pol precursors are capable of reverse transcribing viral genomic RNAQ35823493
Structure of B77 sarcoma virus RNA: stabilization of RNA after packagingQ36568149
Characterization of human immunodeficiency virus type 1 dimeric RNA from wild-type and protease-defective virionsQ36624873
The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency.Q36636632
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.Q36650046
Maturation of dimeric viral RNA of Moloney murine leukemia virus.Q36652049
HIV-1 protease: structure, dynamics, and inhibitionQ36857092
PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processingQ37089562
HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitroQ37427179
Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120Q39612212
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid ProteinQ39748566
Role of human immunodeficiency virus type 1-specific protease in core protein maturation and viral infectivity.Q40115512
Mutant murine leukemia virus Gag proteins lacking proline at the N-terminus of the capsid domain block infectivity in virions containing wild-type Gag.Q40326740
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assemblyQ41047831
Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanismQ41275889
Image reconstructions of helical assemblies of the HIV-1 CA proteinQ41631451
Ordered processing of the human immunodeficiency virus type 1 GagPol precursor is influenced by the context of the embedded viral proteaseQ41997191
Ultrastructure of human retrovirusesQ44966201
Key interactions in HIV-1 maturation identified by hydrogen-deuterium exchange.Q47314618
New hope in HIV diseaseQ47627157
Immunologic and Ultrastructural Characterization of HIV Pseudovirions Containing Gag and Env Precursor Proteins Engineered in Insect CellsQ52550200
A procedure for Northern blot analysis of native RNAQ68984616
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
virionQ1757347
P304page(s)152-160
P577publication date2008-07-26
P1433published inVirologyQ7934867
P1476titleSuboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturation
P478volume379

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cites work (P2860)
Q41730903A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro
Q42546287A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle
Q27677515Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
Q51082089Attenuation of Bleomycin-Induced Pulmonary Fibrosis in Rats with S-Allyl Cysteine.
Q33761008Cryo electron tomography of native HIV-1 budding sites
Q28743199Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1)
Q31106756Generation and characterization of a defective HIV-1 Virus as an immunogen for a therapeutic vaccine.
Q37447762HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.
Q57459053Identification of a Structural Element in HIV-1 Gag Required for Virus Particle Assembly and Maturation
Q35477673Lentiviral Gag assembly analyzed through the functional characterization of chimeric simian immunodeficiency viruses expressing different domains of the feline immunodeficiency virus capsid protein
Q37574479Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors
Q36414162Novel two-round phenotypic assay for protease inhibitor susceptibility testing of recombinant and primary HIV-1 isolates.
Q40732172RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly
Q45388085Role of capsid sequence and immature nucleocapsid proteins p9 and p15 in Human Immunodeficiency Virus type 1 genomic RNA dimerization
Q35073452Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle
Q35215018The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genome
Q39615571The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity

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