The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation

scientific article

The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation is …
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scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2010.01.028
P932PMC publication ID2838455
P698PubMed publication ID20172577
P5875ResearchGate publication ID41509326

P50authorEric O FreedQ67208349
P2093author name stringKunio Nagashima
Benjamin G Luttge
Ferri Soheilian
Mary Ann Checkley
P2860cites workVirus maturation as a new HIV-1 therapeutic targetQ24642446
Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle productionQ27485930
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular cloneQ29547734
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.Q29619254
The structural biology of HIV assemblyQ30437103
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral proteaseQ30850215
Helical structure determined by NMR of the HIV-1 (345-392)Gag sequence, surrounding p2: implications for particle assembly and RNA packagingQ30980940
A putative alpha-helical structure which overlaps the capsid-p2 boundary in the human immunodeficiency virus type 1 Gag precursor is crucial for viral particle assemblyQ33782377
Cleavage of the murine leukemia virus transmembrane env protein by human immunodeficiency virus type 1 protease: transdominant inhibition by matrix mutations.Q33785977
Efficient particle production by minimal Gag constructs which retain the carboxy-terminal domain of human immunodeficiency virus type 1 capsid-p2 and a late assembly domainQ33805303
Ultrastructure of HIV/AIDS.Q34847845
In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).Q35139703
Molecular characterization of feline immunodeficiency virus buddingQ36483903
Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120.Q36632356
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles.Q36650046
In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivityQ36825840
Human immunodeficiency virus type 1 assembly, release, and maturation.Q36857103
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturationQ36944553
PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processingQ37089562
HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.Q37447762
Sequential steps in human immunodeficiency virus particle maturation revealed by alterations of individual Gag polyprotein cleavage sites.Q39579012
N-Terminal extension of human immunodeficiency virus capsid protein converts the in vitro assembly phenotype from tubular to spherical particlesQ39580545
Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag.Q39685850
The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivityQ39870242
The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions.Q40042979
Mutagenesis of protease cleavage sites in the human immunodeficiency virus type 1 gag polyproteinQ40059062
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assemblyQ41047831
Proteolytic processing and particle maturationQ41100821
Image reconstructions of helical assemblies of the HIV-1 CA proteinQ41631451
A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycleQ42546287
A conformational switch controlling HIV-1 morphogenesisQ42690194
HIV-1 gag proteins: diverse functions in the virus life cycleQ43783202
Assembly and analysis of conical models for the HIV-1 core.Q52228420
Cleavage of HIV-1 gag polyprotein synthesized in vitro: sequential cleavage by the viral proteaseQ69564852
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectHIVQ15787
P304page(s)137-144
P577publication date2010-02-20
P1433published inVirologyQ7934867
P1476titleThe capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation
P478volume400

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cites work (P2860)
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