Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications

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Fundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2010.06.042
P932PMC publication ID2963451
P698PubMed publication ID20655566
P5875ResearchGate publication ID45286503

P50authorSiddhartha A.K. DattaQ57422711
Robert J GorelickQ87445459
P2093author name stringAlan Rein
Judith G Levin
Tiyun Wu
Mithun Mitra
P2860cites workNucleic acid binding and chaperone properties of HIV-1 Gag and nucleocapsid proteinsQ25257759
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Coupled integration of human immunodeficiency virus type 1 cDNA ends by purified integrase in vitro: stimulation by the viral nucleocapsid proteinQ30453495
The role of Pr55(gag) in the annealing of tRNA3Lys to human immunodeficiency virus type 1 genomic RNAQ30453508
Interactions of HIV-1 Gag with assembly cofactorsQ33237729
APOBEC3G inhibits elongation of HIV-1 reverse transcriptsQ33389841
The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral buddingQ33417652
C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanismQ33581258
Human immunodeficiency virus type 1 nucleocapsid protein can prevent self-priming of minus-strand strong stop DNA by promoting the annealing of short oligonucleotides to hairpin sequencesQ33603932
Zinc finger structures in the human immunodeficiency virus type 1 nucleocapsid protein facilitate efficient minus- and plus-strand transferQ33604321
Coronavirus nucleocapsid protein facilitates template switching and is required for efficient transcriptionQ33614644
The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding siteQ33647840
In vitro assembly properties of human immunodeficiency virus type 1 Gag protein lacking the p6 domain.Q33653475
Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domainQ33667586
The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturationQ33727091
Human immunodeficiency virus type 1 N-terminal capsid mutants that exhibit aberrant core morphology and are blocked in initiation of reverse transcription in infected cellsQ33845811
Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequencesQ33930053
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Self-assembly in vitro of purified CA-NC proteins from Rous sarcoma virus and human immunodeficiency virus type 1.Q34304675
Human immunodeficiency virus type 1 nucleocapsid zn(2+) fingers are required for efficient reverse transcription, initial integration processes, and protection of newly synthesized viral DNA.Q34464770
Intra-tRNA distance measurements for nucleocapsid proteindependent tRNA unwinding during priming of HIV reverse transcriptionQ34813558
Interactions between HIV-1 Gag molecules in solution: an inositol phosphate-mediated switchQ35691189
The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenanceQ35724976
Conformation of the HIV-1 Gag protein in solution.Q35785819
Human immunodeficiency virus type 1 virions composed of unprocessed Gag and Gag-Pol precursors are capable of reverse transcribing viral genomic RNAQ35823493
Rapid kinetics of protein-nucleic acid interaction is a major component of HIV-1 nucleocapsid protein's nucleic acid chaperone functionQ56893915
Heteronuclear NMR studies of the interaction of tRNA3Lys with HIV-1 nucleocapsid protein11Edited by M. F. SummersQ57526892
NCp7 activates HIV-1Lai RNA dimerization by converting a transient loop-loop complex into a stable dimerQ71903508
Molecular recognition in the HIV-1 capsid/cyclophilin A complexQ73511357
Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: significance for viral replicationQ77362262
Alteration of nucleic acid structure and stability modulates the efficiency of minus-strand transfer mediated by the HIV-1 nucleocapsid proteinQ80375482
Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesisQ81690042
Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine tractQ35870861
Primer tRNA3Lys on the viral genome exists in unextended and two-base extended forms within mature human immunodeficiency virus type 1.Q35875824
Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self-priming from minus-strand strong-stop DNA.Q35888060
Effects of nucleic acid local structure and magnesium ions on minus-strand transfer mediated by the nucleic acid chaperone activity of HIV-1 nucleocapsid proteinQ35891627
Measuring the binding stoichiometry of HIV-1 Gag to very-low-density oligonucleotide surfaces using surface plasmon resonance spectroscopy.Q36114072
Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanismQ36258296
Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G.Q36328929
Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.Q36857096
Human immunodeficiency virus type 1 assembly, release, and maturation.Q36857103
Mutations in human immunodeficiency virus type 1 nucleocapsid protein zinc fingers cause premature reverse transcriptionQ36898781
Nucleocapsid protein function in early infection processesQ37086413
Strand transfer events during HIV-1 reverse transcriptionQ37086417
RNA chaperones, RNA annealers and RNA helicasesQ37112437
Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle productionQ37247951
Peeling back the mystery of DNA overstretching.Q37416509
HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitroQ37427179
HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.Q37447762
Defects in primer-template binding, processive DNA synthesis, and RNase H activity associated with chimeric reverse transcriptases having the murine leukemia virus polymerase domain joined to Escherichia coli RNase H.Q38296468
DNA strand exchange and selective DNA annealing promoted by the human immunodeficiency virus type 1 nucleocapsid proteinQ38304784
A HIV-1 minimal gag protein is superior to nucleocapsid at in vitro annealing and exhibits multimerization-induced inhibition of reverse transcriptionQ38330143
Possible roles of HIV-1 nucleocapsid protein in the specificity of proviral DNA synthesis and in its variabilityQ38346120
Compensatory point mutations in the human immunodeficiency virus type 1 Gag region that are distal from deletion mutations in the dimerization initiation site can restore viral replicationQ39579618
Roles of the human immunodeficiency virus type 1 nucleocapsid protein in annealing and initiation versus elongation in reverse transcription of viral negative-strand strong-stop DNAQ39582290
Roles of Pr55(gag) and NCp7 in tRNA(3)(Lys) genomic placement and the initiation step of reverse transcription in human immunodeficiency virus type 1.Q39585566
Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid ProteinQ39748566
Roles of Gag and NCp7 in facilitating tRNA(Lys)(3) Annealing to viral RNA in human immunodeficiency virus type 1Q39843165
A large deletion in the matrix domain of the human immunodeficiency virus gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic reticulumQ40046621
Mutant murine leukemia virus Gag proteins lacking proline at the N-terminus of the capsid domain block infectivity in virions containing wild-type Gag.Q40326740
Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tailQ40579232
Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assemblyQ41047831
Small finger protein of avian and murine retroviruses has nucleic acid annealing activity and positions the replication primer tRNA onto genomic RNA.Q41107385
A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycleQ42546287
A conformational switch controlling HIV-1 morphogenesisQ42690194
HIV-1 gag proteins: diverse functions in the virus life cycleQ43783202
HIV-1 nucleocapsid protein zinc finger structures induce tRNA(Lys,3) structural changes but are not critical for primer/template annealingQ44253743
Preparation of recombinant HIV-1 gag protein and assembly of virus-like particles in vitro.Q45388539
Human immunodeficiency virus type 1 nucleocapsid zinc-finger mutations cause defects in reverse transcription and integrationQ45415531
Actin-binding cellular proteins inside human immunodeficiency virus type 1.Q45745422
Cis elements and trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1.Q45852163
In vitro identification and characterization of an early complex linking HIV-1 genomic RNA recognition and Pr55Gag multimerizationQ47215552
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmolecular chaperonesQ422496
viral nucleocapsidQ4384107
P304page(s)556-567
P577publication date2010-07-23
P1433published inVirologyQ7934867
P1476titleFundamental differences between the nucleic acid chaperone activities of HIV-1 nucleocapsid protein and Gag or Gag-derived proteins: biological implications
P478volume405

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cites work (P2860)
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