A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny

scientific article published on 7 July 2016

A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/V8070189
P932PMC publication ID4974524
P698PubMed publication ID27399760

P2093author name stringB Matija Peterlin
Luciana Jesus da Costa
Marcela Sabino Cunha
Thatiane Lima Sampaio
P2860cites workOrigin of HIV-1 in the chimpanzee Pan troglodytes troglodytesQ22251299
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by NefQ24338889
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporationQ24338895
Structure--function relationships in HIV-1 Nef.Q24522550
Retroviruses have differing requirements for proteasome function in the budding processQ24550599
The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 productionQ24557498
The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motifQ24596374
A role for ubiquitin ligase recruitment in retrovirus releaseQ24642874
Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2Q24643016
Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different ratesQ24812175
Human immunodeficiency viruses: SIV infection in wild gorillasQ28273219
CD4 downregulation by the human immunodeficiency virus type 1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cellsQ45372692
Virological importance of the protease-cleavage site in human immunodeficiency virus type 1 Nef is independent of both intravirion processing and CD4 down-regulation.Q45752560
Generation and characterization of the human immunodeficiency virus type 1 mutantsQ45859881
Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replicationQ47817189
An African primate lentivirus (SIVsm) closely related to HIV-2.Q48295012
HIV-1 Nef inhibits Protease activity and its absence alters protein content of mature viral particlesQ28538038
AIDS as a zoonosis: scientific and public health implicationsQ29617393
Exploring the functional interaction between POSH and ALIX and the relevance to HIV-1 releaseQ30157284
Functional characterization of HIV-1 Nef mutants in the context of viral infectionQ30159805
Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.Q30176459
Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.Q30193319
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable mannerQ33333829
The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturationQ33727091
The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity.Q33783315
Inhibition of human immunodeficiency virus type 1 virion entry by dominant-negative Hck.Q33785940
Association of Nef with the human immunodeficiency virus type 1 coreQ33821376
Human immunodeficiency virus type 1 negative factor is a transcriptional silencerQ33836630
Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivityQ33843610
Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicityQ33929164
Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.Q34323971
Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitorQ34323995
Equine infectious anemia virus and the ubiquitin-proteasome systemQ34332683
Budding of equine infectious anemia virus is insensitive to proteasome inhibitorsQ34332698
NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domainsQ34758977
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesisQ35845204
Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion proteinQ35863401
Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral proteaseQ35876343
Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1Q36098898
Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.Q36524357
Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.Q36651371
The role of ubiquitin in retroviral egressQ36889025
Conservation of Nef function across highly diverse lineages of SIVsmmQ37182075
HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.Q37447762
Human infection by genetically diverse SIVSM-related HIV-2 in west AfricaQ39242650
cis expression of the F12 human immunodeficiency virus (HIV) Nef allele transforms the highly productive NL4-3 HIV type 1 to a replication-defective strain: involvement of both Env gp41 and CD4 intracytoplasmic tails.Q39588750
A nonproducer, interfering human immunodeficiency virus (HIV) type 1 provirus can be transduced through a murine leukemia virus-based retroviral vector: recovery of an anti-HIV mouse/human pseudotype retrovirus.Q39872193
Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentivirusesQ40069610
Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1.Q40815179
Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef proteinQ40947083
Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramolecular mechanismQ41275889
The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.Q41290352
Differential effects of nef on HIV replication: implications for viral pathogenesis in the hostQ41757870
Ordered processing of the human immunodeficiency virus type 1 GagPol precursor is influenced by the context of the embedded viral proteaseQ41997191
Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaquesQ42068006
A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycleQ42546287
Role of myristoylation and N-terminal basic residues in membrane association of the human immunodeficiency virus type 1 Nef proteinQ44154949
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P577publication date2016-07-07
P1433published inVirusesQ7935305
P1476titleA Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny
P478volume8

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