Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag

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Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01626-06
P932PMC publication ID1676313
P698PubMed publication ID17035324

P2093author name stringJing Zhou
Christopher Aiken
Chin Ho Chen
P2860cites workThe sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acidQ24793247
Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturationQ28360742
Gene splicing by overlap extension: tailor-made genes using the polymerase chain reactionQ29615257
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesisQ35845204
Betulinic acid derivatives as HIV-1 antiviralsQ36009015
The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV.Q36187060
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturationQ36944553
PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processingQ37089562
Characterization of a putative alpha-helix across the capsid-SP1 boundary that is critical for the multimerization of human immunodeficiency virus type 1 gag.Q39685850
Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.Q39880513
Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particlesQ40357793
Mutation of the SP1 sequence impairs both multimerization and membrane-binding activities of human immunodeficiency virus type 1 Gag.Q40894533
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivativesQ41066416
Proteolytic processing and particle maturationQ41100821
3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitroQ42424208
The R362A mutation at the C-terminus of CA inhibits packaging of human immunodeficiency virus type 1 RNA.Q44003068
p24 antigen capture assay for quantification of human immunodeficiency virus using readily available inexpensive reagentsQ45761377
P433issue24
P304page(s)12095-12101
P577publication date2006-10-11
P1433published inJournal of VirologyQ1251128
P1476titleHuman immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag
P478volume80

Reverse relations

cites work (P2860)
Q39917695A single amino acid substitution in a segment of the CA protein within Gag that has similarity to human immunodeficiency virus type 1 blocks infectivity of a human endogenous retrovirus K provirus in the human genome
Q42546287A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle
Q27324263Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors
Q37287731Fullerene Derivatives Strongly Inhibit HIV-1 Replication by Affecting Virus Maturation without Impairing Protease Activity
Q24614498HIV type 1 Gag as a target for antiviral therapy
Q35761626HIV-1 Gag as an Antiviral Target: Development of Assembly and Maturation Inhibitors
Q38366763HIV-1 gag: an emerging target for antiretroviral therapy.
Q34529834HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice
Q33351623High-throughput screening-based identification of paramyxovirus inhibitors
Q38032330Human Immunodeficiency Virus Gag and protease: partners in resistance
Q35992805Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Q28829072Identification of potent maturation inhibitors against HIV-1 clade C
Q37192174Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457)
Q24617174Improved Bevirimat resistance prediction by combination of structural and sequence-based classifiers
Q37901613New approaches for antiviral targeting of HIV assembly
Q33624690Novel approaches to inhibiting HIV-1 replication.
Q26771739Pharmacological intervention of HIV-1 maturation
Q33864444Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat
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Q21284351Predicting Bevirimat resistance of HIV-1 from genotype
Q41844750Protease-Mediated Maturation of HIV: Inhibitors of Protease and the Maturation Process
Q36967857Recent progress in antiretrovirals--lessons from resistance
Q90646261Resistance to Second-Generation HIV-1 Maturation Inhibitors
Q28485054Structural and functional insights into the HIV-1 maturation inhibitor binding pocket
Q28828191Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396
Q37928913Targeting human immunodeficiency virus type 1 assembly, maturation and budding.
Q37979697Targets for inhibition of HIV replication: entry, enzyme action, release and maturation
Q30437103The structural biology of HIV assembly
Q39630669Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication
Q33356201Understanding HIV-1 protease autoprocessing for novel therapeutic development
Q33774977Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid
Q24642446Virus maturation as a new HIV-1 therapeutic target

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