Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles

scientific article published on 25 October 2005

Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M508951200
P698PubMed publication ID16251182

P50authorLi HuangQ39375954
P2093author name stringJing Zhou
Christopher Aiken
David L Hachey
Chin Ho Chen
P2860cites workThe sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acidQ24793247
Entropic switch regulates myristate exposure in the HIV-1 matrix proteinQ27642873
Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug designQ27730329
High-efficiency transformation of mammalian cells by plasmid DNAQ27860469
AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assemblyQ28239650
HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulatorQ28307391
Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturationQ28360742
The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoatingQ30196243
The stoichiometry of Gag protein in HIV-1.Q34328141
Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartmentsQ34618267
Betulinic acid derivatives as HIV-1 antiviralsQ36009015
Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturationQ36944553
PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processingQ37089562
Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particlesQ39593215
Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tailQ40579232
Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivativesQ41066416
Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cellsQ42073571
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoidsQ42285617
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agentsQ42555749
p24 antigen capture assay for quantification of human immunodeficiency virus using readily available inexpensive reagentsQ45761377
P433issue51
P407language of work or nameEnglishQ1860
P304page(s)42149-42155
P577publication date2005-10-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleInhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles
P478volume280

Reverse relations

cites work (P2860)
Q424242083-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro
Q282946773D Visualization of HIV Virions by Cryoelectron Tomography
Q34771244A sensitive assay using a native protein substrate for screening HIV-1 maturation inhibitors targeting the protease cleavage site between the matrix and capsid
Q42546287A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle
Q37336728A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.
Q27324263Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors
Q45324180Alpha-helicoidal HEAT-like Repeat Proteins (αRep) Selected as Interactors of HIV-1 Nucleocapsid Negatively Interfere with Viral Genome Packaging and Virus Maturation
Q34552402Analysis of the N-terminal region of the murine leukemia virus nucleocapsid protein
Q38106149Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro
Q45173552Determinants of activity of the HIV-1 maturation inhibitor PA-457.
Q30479297Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shells
Q37287731Fullerene Derivatives Strongly Inhibit HIV-1 Replication by Affecting Virus Maturation without Impairing Protease Activity
Q24614498HIV type 1 Gag as a target for antiviral therapy
Q38539565HIV-1 assembly, release and maturation.
Q34529834HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice
Q36857103Human immunodeficiency virus type 1 assembly, release, and maturation.
Q30478394Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag
Q35992805Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Q37192174Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457)
Q35107346Impaired infectivity of ritonavir-resistant HIV is rescued by heat shock protein 90AB1.
Q35184863In vitro analysis of human immunodeficiency virus particle dissociation: gag proteolytic processing influences dissociation kinetics
Q30832180In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway
Q35139703In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).
Q38716274Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein
Q28554482Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors
Q37967727Morphogenesis of the Infectious HIV-1 Virion
Q39763774Mutations in the spacer peptide and adjoining sequences in Rous sarcoma virus Gag lead to tubular budding
Q37901613New approaches for antiviral targeting of HIV assembly
Q36691642New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.
Q43100320New triterpenoids from Arisaema jacquemontii
Q33624690Novel approaches to inhibiting HIV-1 replication.
Q26771739Pharmacological intervention of HIV-1 maturation
Q40750425Phenotypic susceptibility to bevirimat in isolates from HIV-1-infected patients without prior exposure to bevirimat
Q33864444Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat
Q21092230Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice
Q41844750Protease-Mediated Maturation of HIV: Inhibitors of Protease and the Maturation Process
Q36967857Recent progress in antiretrovirals--lessons from resistance
Q90646261Resistance to Second-Generation HIV-1 Maturation Inhibitors
Q25256613Review of "the Twelfth West Coast Retrovirus Meeting" and "the Twenty-third Annual Symposium on Nonhuman Primate Models for AIDS".
Q24812436Review of the twelfth West Coast Retrovirus Meeting
Q28485054Structural and functional insights into the HIV-1 maturation inhibitor binding pocket
Q28828191Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396
Q37928913Targeting human immunodeficiency virus type 1 assembly, maturation and budding.
Q27009643The choreography of HIV-1 proteolytic processing and virion assembly
Q30440445The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain
Q21245046The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles
Q30437103The structural biology of HIV assembly
Q39630669Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication
Q24642446Virus maturation as a new HIV-1 therapeutic target

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