Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response

scientific article published on 13 May 2016

Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M116.729343
P932PMC publication ID4933190
P698PubMed publication ID27226613

P2093author name stringTao Wang
Yi Yang
Jin Xu
Zhenlin Zhang
Meiling Qin
Puhua Bao
Wangchao Xu
Fuxiao Shen
P2860cites workThe Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosisQ24298775
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p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylationQ39866014
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Inhibition of autophagy, lysosome and VCP function impairs stress granule assemblyQ42030945
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ATPase activity of p97-valosin-containing protein (VCP). D2 mediates the major enzyme activity, and D1 contributes to the heat-induced activityQ28215759
Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformationQ28247784
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VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutationsQ30540665
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD modelQ33815368
Uncovering global SUMOylation signaling networks in a site-specific mannerQ34041994
Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinomaQ34117172
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Generation of human induced pluripotent stem cells from urine samples.Q34310664
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Nucleocytoplasmic shuttling of valosin-containing protein (VCP/p97) regulated by its N domain and C-terminal regionQ34625857
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Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding.Q35102083
Structural insights into the p97-Ufd1-Npl4 complex.Q35568482
The Role of SUMO-Conjugating Enzyme Ubc9 in the Neuroprotection of Isoflurane Preconditioning Against Ischemic Neuronal InjuryQ35619730
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseasesQ35976721
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functionsQ36215827
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectprotein sumoylationQ3503705
P304page(s)14373-14384
P577publication date2016-05-13
P1433published inJournal of Biological ChemistryQ867727
P1476titlePathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response
P478volume291