Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis

scientific article published on January 2008

Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1515/REVNEURO.2008.19.4-5.327
P932PMC publication ID2629410
P698PubMed publication ID19145988

P50authorSushmita SinhaQ59677276
Halina OffnerQ89146584
P2093author name stringArthur A Vandenbark
Gregory G Burrows
Chunhe Wang
P2860cites workStructural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigenQ27748865
A rationally designed CD4 analogue inhibits experimental allergic encephalomyelitisQ28251844
Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitisQ28584050
IL-17 family cytokines and the expanding diversity of effector T cell lineagesQ29619361
Signal transduction by lymphocyte antigen receptorsQ29619894
Cytokines and the central nervous systemQ34221106
Multiple sclerosis: more than inflammation and demyelinationQ34327785
Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale.Q34413750
Axonal injury in multiple sclerosisQ35105813
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.Q36189566
Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE.Q36329275
Models of T cell anergy: is there a common molecular mechanism?Q36366967
Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligandsQ36367500
Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitisQ36368128
T(H)-17 cells in the circle of immunity and autoimmunityQ36765453
Pathogenesis of axonal and neuronal damage in multiple sclerosisQ36840382
Natalizumab for multiple sclerosisQ36854538
MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8Q38329233
Multiple sclerosis: an immunologic reassessmentQ39897571
T-Cell-Mediated Immunopathology in Viral InfectionsQ39943334
Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injuryQ40390990
Regulation and function of p21ras in T lymphocytes.Q40508456
Regulation of encephalitogenic T cells with recombinant TCR ligandsQ40875297
Altered T cell receptor ligands trigger a subset of early T cell signalsQ41180292
Myelin basic protein specific T cell lines and clones derived from the CNS of rats with EAE only recognize encephalitogenic epitopesQ41663454
Vaccination against experimental allergic encephalomyelitis with T cell receptor peptidesQ43794379
Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activationQ44539452
Opposing roles for TGF-beta1 and TGF-beta3 isoforms in experimental autoimmune encephalomyelitisQ44704488
Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice.Q44870661
Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitisQ45351794
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.Q46007698
Ligand recognition by alpha beta T cell receptorsQ46222293
Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosisQ46253564
Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic miceQ47817045
Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switchQ47914644
Increases in soluble VCAM-1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon beta-1bQ48718477
Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple SclerosisQ50127386
A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.Q50657622
Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules.Q52443678
Definition of encephalitogenic and immunodominant epitopes of guinea pig myelin basic protein (Gp-BP) in Lewis rats tolerized neonatally with Gp-BP or Gp-BP peptides.Q54199477
Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury.Q55480343
α4Integrins as Therapeutic Targets in Autoimmune DiseaseQ58199770
Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsivenessQ70179724
The effect of interferon-beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosisQ72249443
Design, engineering and production of functional single-chain T cell receptor ligandsQ73041460
Design, engineering, and production of human recombinant t cell receptor ligands derived from human leukocyte antigen DR2Q73798778
Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI resultsQ74009726
Demyelinating diseases--new pathological insights, new therapeutic targetsQ74100782
Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cellsQ74601834
Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligandsQ77929073
Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic miceQ79674405
P433issue4-5
P921main subjectmultiple sclerosisQ8277
P304page(s)327-339
P577publication date2008-01-01
P1433published inReviews in the NeurosciencesQ15750651
P1476titleRecombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis
P478volume19

Reverse relations

cites work (P2860)
Q61445020A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury
Q34077153Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.
Q34350992Characterization of human platelet binding of recombinant T cell receptor ligand.
Q37149410Effective Arrestin-Specific Immunotherapy of Experimental Autoimmune Uveitis with RTL: A Prospect for Treatment of Human Uveitis
Q37351198Induction of tolerance against the arthritogenic antigen with type-II collagen peptide-linked soluble MHC class II molecules
Q35722702Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity
Q35797272Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice
Q28742932RTL551 treatment of EAE reduces CD226 and T-bet+ CD4 T cells in periphery and prevents infiltration of T-bet+ IL-17, IFN-γ producing T cells into CNS
Q35893543Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study
Q33645392Sex-dependent treatment of chronic EAE with partial MHC class II constructs
Q36231789Systemic immunotherapy delays photoreceptor cell loss and prevents vascular pathology in Royal College of Surgeons rats.
Q35036755Therapy with recombinant T-cell receptor ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in mice

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