Evaluation of strategies for improving proteolytic resistance of antimicrobial peptides by using variants of EFK17, an internal segment of LL-37.

scientific article

Evaluation of strategies for improving proteolytic resistance of antimicrobial peptides by using variants of EFK17, an internal segment of LL-37. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.00477-08
P932PMC publication ID2630634
P698PubMed publication ID19029324

P50authorArtur SchmidtchenQ88461456
Mukesh PasupuletiQ41552759
Martin MalmstenQ58780071
P2093author name stringAdam A Strömstedt
P2860cites workThe human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytesQ24336630
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A simple method for displaying the hydropathic character of a proteinQ26778481
LL-37, the only human member of the cathelicidin family of antimicrobial peptidesQ28241675
Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and TrpQ28271872
Cation-pi interactions in structural biologyQ29617384
A PhoP-regulated outer membrane protease of Salmonella enterica serovar typhimurium promotes resistance to alpha-helical antimicrobial peptides.Q30453404
Internalisation and degradation of histatin 5 by Candida albicansQ30911101
The preference of tryptophan for membrane interfaces.Q31997161
Proteus mirabilis ZapA metalloprotease degrades a broad spectrum of substrates, including antimicrobial peptidesQ33206136
Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of actionQ33245928
Aromatic-aromatic interactions and protein stability. Investigation by double-mutant cyclesQ33527126
All-D amino acid-containing channel-forming antibiotic peptidesQ33643488
Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophilsQ33695688
Substrate specificity of three different extracellular proteolytic enzymes from Staphylococcus aureusQ69363078
Peptide synthesis catalysed by Pseudomonas aeruginosa elastaseQ70688521
Fine chemical modifications at N- and C-termini enhance peptide presentation to T cells by increasing the lifespan of both free and MHC-complexed peptidesQ71108234
Computed circular dichroism spectra for the evaluation of protein conformationQ71225133
Peptide stability in drug development. II. Effect of single amino acid substitution and glycosylation on peptide reactivity in human serumQ72589601
The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epitheliumQ73043045
The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophilsQ73774823
Energetics of polar side-chain interactions in helical peptides: salt effects on ion pairs and hydrogen bondsQ74023804
Structural consequences of carboxyamidation of dermaseptin S3Q74226357
Formation of model lipid bilayers at the silica-water interface by co-adsorption with non-ionic dodecyl maltoside surfactantQ74251707
Amphipathic alpha helical antimicrobial peptidesQ77086082
Apolipoprotein A-I binds and inhibits the human antibacterial/cytotoxic peptide LL-37Q77630845
Antifungal activity of C3a and C3a-derived peptides against CandidaQ79433625
Effect of peptide length on the interaction between consensus peptides and DOPC/DOPA bilayersQ83343090
Antimicrobial and chemoattractant activity, lipopolysaccharide neutralization, cytotoxicity, and inhibition by serum of analogs of human cathelicidin LL-37.Q33883780
Bactericidal activity of mammalian cathelicidin-derived peptides.Q34004332
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substancesQ34750112
In silico identification and biological evaluation of antimicrobial peptides based on human cathelicidin LL-37Q35023257
Bacterial evasion of innate defense at epithelial liningsQ36173729
Antimicrobial peptide resistance mechanisms of human bacterial pathogens.Q36383728
Alpha-helical antimicrobial peptides--using a sequence template to guide structure-activity relationship studiesQ36469872
Molecular mechanisms of bacterial resistance to antimicrobial peptides.Q36566222
Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guideQ37284698
Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinasesQ37624709
Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37.Q38362260
Interactions of tryptophan-rich cathelicidin antimicrobial peptides with model membranes studied by differential scanning calorimetryQ40199965
Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domainQ40432691
Are bacterial proteinases pathogenic factors?Q40947491
Composition effect on peptide interaction with lipids and bacteria: variants of C3a peptide CNY21.Q41047319
Controlled alteration of the shape and conformational stability of alpha-helical cell-lytic peptides: effect on mode of action and cell specificity.Q41906637
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activityQ42158764
Cooperative helix stabilization by complex Arg-Glu salt bridges.Q43028867
Cation-pi interaction in model alpha-helical peptides.Q43934981
Contribution of aromatic interactions to alpha-helix stabilityQ44099740
Further studies of the helix dipole model: effects of a free alpha-NH3+ or alpha-COO- group on helix stabilityQ45735421
Role of the S' subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni.Q46008032
Mapping the S' subsites of serine proteases using acyl transfer to mixtures of peptide nucleophilesQ46071689
Comparison of the helix-coil transition of a titrating polypeptide in aqueous solutions and at the air-water interfaceQ46505055
Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic applicationQ46869207
An electrochemical study into the interaction between complement-derived peptides and DOPC mono- and bilayersQ46871884
Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membraneQ50128217
Thermodynamics of the alpha-helix-coil transition of amphipathic peptides in a membrane environment: implications for the peptide-membrane binding equilibrium.Q52131787
Effect of D-amino acid substitution on the stability, the secondary structure, and the activity of membrane-active peptide.Q52537084
Mechanism of fluorescence concentration quenching of carboxyfluorescein in liposomes: energy transfer to nonfluorescent dimers.Q52561693
Formation of supported phospholipid bilayers via co-adsorption with beta-D-dodecyl maltoside.Q53627574
Purification and Properties of an Extracellular Protease of Staphylococcus aureusQ54005456
All-D-magainin: chirality, antimicrobial activity and proteolytic resistance.Q54311933
Specificity in transmembrane helix-helix interactions mediated by aromatic residues.Q54441747
Effects of topology, length, and charge on the activity of a kininogen-derived peptide on lipid membranes and bacteria.Q54448979
Substrate specificity in the highly heterogeneous M4 peptidase family is determined by a small subset of amino acidsQ56901567
Effect of lipid headgroup composition on the interaction between melittin and lipid bilayersQ61644817
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
antimicrobial peptideQ1201508
antimicrobial resistanceQ63391344
P304page(s)593-602
P577publication date2008-11-24
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleEvaluation of strategies for improving proteolytic resistance of antimicrobial peptides by using variants of EFK17, an internal segment of LL-37.
P478volume53

Reverse relations

cites work (P2860)
Q33804128Accurate mass comparison coupled with two endopeptidases enables identification of protein termini
Q37372512Alpha-1 antitrypsin reduces severity of pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and pseudomonas invasion of respiratory epithelial cells
Q48366454Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1.
Q52592947Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds.
Q36959721Antimicrobial activity, improved cell selectivity and mode of action of short PMAP-36-derived peptides against bacteria and Candida
Q26829600Antimicrobial peptides
Q37954721Antimicrobial peptides: key components of the innate immune system
Q38265118Antimicrobial peptides: therapeutic potentials
Q37500469Antimicrobial properties and membrane-active mechanism of a potential α-helical antimicrobial derived from cathelicidin PMAP-36.
Q90176517Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
Q47601044Bcl-XL-binding helical peptides possessing d-Ala residues at their C-termini with the advantage of long-lasting intracellular stabilities
Q38135778Bioassays in natural product research - strategies and methods in the search for anti-inflammatory and antimicrobial activity
Q37285243Boosting antimicrobial peptides by hydrophobic oligopeptide end tags
Q36182408Cathelicidin Insufficiency in Patients with Fatal Leptospirosis
Q41869149Characterization of Antimicrobial Peptides toward the Development of Novel Antibiotics
Q35866086Comparative Evaluation of the Antimicrobial Activity of Different Antimicrobial Peptides against a Range of Pathogenic Bacteria
Q47777488De novo generation of short antimicrobial peptides with enhanced stability and cell specificity
Q40775683Effects of N-terminus modifications on the conformation and permeation activities of the synthetic peptide L1A.
Q36132580Effects of a single nucleotide polymorphism in the chicken NK-lysin gene on antimicrobial activity and cytotoxicity of cancer cells.
Q42060877Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha
Q38982372Efficacy of the designer antimicrobial peptide SHAP1 in wound healing and wound infection
Q36238251Helical antimicrobial polypeptides with radial amphiphilicity
Q41016131Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy.
Q34441271Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to gram-positive bacterial pathogens
Q41790542Lipid segregation explains selective toxicity of a series of fragments derived from the human cathelicidin LL-37.
Q48147388Mechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa.
Q52682682Membrane interactions and antimicrobial effects of layered double hydroxide nanoparticles.
Q41907587Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis.
Q41887880Primary structure and antibacterial activity of chicken bone marrow-derived beta-defensins
Q33912692Protease-resistant peptide ligands from a knottin scaffold library
Q42067261Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency
Q30413794Robust, quantitative analysis of proteins using peptide immunoreagents, in vitro translation, and an ultrasensitive acoustic resonant sensor
Q64115635Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection
Q59807100Short Symmetric-End Antimicrobial Peptides Centered on β-Turn Amino Acids Unit Improve Selectivity and Stability
Q38264736Strategic approaches to optimizing peptide ADME properties
Q37122994Structure-activity relationship of synthetic variants of the milk-derived antimicrobial peptide αs2-casein f(183-207).
Q49490467The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs
Q50786210The antimicrobial peptide LL37 and its truncated derivatives potentiates proinflammatory cytokine induction by lipoteichoic acid in whole blood
Q47714243Tryptophan-Containing Cyclic Decapeptides with Activity against Plant Pathogenic Bacteria.
Q21559399β-Microseminoprotein endows post coital seminal plasma with potent candidacidal activity by a calcium- and pH-dependent mechanism

Search more.