Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis.

scientific article published on 25 November 2013

Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.01167-13
P932PMC publication ID3910818
P698PubMed publication ID24277028

P50authorCatherine M GreeneQ56915426
Deirdre Fitzgerald-HughesQ57789080
Marc C DevocelleQ61827211
Hilary HumphreysQ64729399
P2093author name stringEanna Forde
P2860cites workAncient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new optionsQ21091000
Antimicrobial peptides of multicellular organismsQ28131811
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategiesQ29617810
High-throughput generation of small antibacterial peptides with improved activityQ33220258
Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosisQ33874056
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activityQ33876601
Antimicrobial peptide therapeutics for cystic fibrosisQ33883742
Bacterial host interactions in cystic fibrosisQ34089951
Magainins and the disruption of membrane-linked free-energy transductionQ34300587
Enhanced membrane pore formation through high-affinity targeted antimicrobial peptidesQ34328258
Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathwayQ34606483
Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?Q35010044
Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptideQ35127866
Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed cultureQ35203439
A novel target-specific, salt-resistant antimicrobial peptide against the cariogenic pathogen Streptococcus mutansQ35363615
Pathophysiology and Management of Pulmonary Infections in Cystic FibrosisQ35557791
Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug-resistant pathogensQ37026697
Evaluation of strategies for improving proteolytic resistance of antimicrobial peptides by using variants of EFK17, an internal segment of LL-37.Q37072064
Proteases and cystic fibrosisQ37131650
Platelet microbicidal proteins and neutrophil defensin disrupt the Staphylococcus aureus cytoplasmic membrane by distinct mechanisms of actionQ37377013
Clinical challenges in addressing resistance to antimicrobial drugs in the twenty-first centuryQ37538527
Has the era of untreatable infections arrived?Q37578902
Designing antimicrobial peptides: form follows function.Q37968899
Challenges with current inhaled treatments for chronic Pseudomonas aeruginosa infection in patients with cystic fibrosisQ37991778
Beyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternativesQ37992706
Current dilemmas in antimicrobial therapy in cystic fibrosis.Q38042719
Treatment of lung infection in patients with cystic fibrosis: current and future strategiesQ38058617
Inhaled antibiotics for the treatment of chronic bronchopulmonary Pseudomonas aeruginosa infection in cystic fibrosis: systematic review of randomised controlled trialsQ38099053
Human host defense peptide LL-37 prevents bacterial biofilm formationQ38289682
Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell linesQ39203205
Biological properties of structurally related alpha-helical cationic antimicrobial peptidesQ39510622
Antimicrobial activity of the recombinant designer host defence peptide P-novispirin G10 in infected full-thickness wounds of porcine skin.Q40243759
TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells.Q40468230
Translocating proline-rich peptides from the antimicrobial peptide bactenecin 7.Q40687738
Targeted antimicrobial peptides.Q41854349
In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogensQ42058965
Salt resistance and synergistic effect with vancomycin of alpha-helical antimicrobial peptide P18.Q43846571
The antimicrobial activity of the cathelicidin LL37 is inhibited by F-actin bundles and restored by gelsolinQ44296193
Comparison of two treatment regimens for eradication of Pseudomonas aeruginosa infection in children with cystic fibrosisQ44412993
Glycosaminoglycans inhibit the antibacterial activity of LL-37 in biological fluidsQ46875179
Inhibition of neutrophil elastase in CF sputum by L-658,758.Q48541764
Nebulised 7% hypertonic saline improves lung function and quality of life in bronchiectasisQ48563615
Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membraneQ50128217
Release of the antimicrobial peptide LL-37 from DNA/F-actin bundles in cystic fibrosis sputum.Q51084969
Effect of D-amino acid substitution on the stability, the secondary structure, and the activity of membrane-active peptide.Q52537084
All-D-magainin: chirality, antimicrobial activity and proteolytic resistance.Q54311933
LL-37 Complexation with Glycosaminoglycans in Cystic Fibrosis Lungs Inhibits Antimicrobial Activity, Which Can Be Restored by Hypertonic SalineQ58817684
Targeting neutrophil elastase in cystic fibrosisQ60056989
Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melittin hybrid peptidesQ77296547
The antimicrobial peptide cathelicidin interacts with airway mucusQ80236200
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcystic fibrosisQ178194
P1104number of pages8
P304page(s)978-985
P577publication date2013-11-25
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titlePotential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis
P478volume58

Reverse relations

cites work (P2860)
Q35607838Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia.
Q27027316Antimicrobial peptides in 2014
Q55263222Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria.
Q33809988D-BMAP18 Antimicrobial Peptide Is Active In vitro, Resists to Pulmonary Proteases but Loses Its Activity in a Murine Model of Pseudomonas aeruginosa Lung Infection
Q27301457Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles
Q41289926Differential In Vitro and In Vivo Toxicities of Antimicrobial Peptide Prodrugs for Potential Use in Cystic Fibrosis.
Q38755670Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation
Q38814378Eradication of Staphylococcus aureus Biofilm Infections Using Synthetic Antimicrobial Peptides.
Q33673156Human antimicrobial peptides and proteins
Q33897664Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa
Q38369494Modifications of natural peptides for nanoparticle and drug design
Q28071357Neutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway disease
Q96303360Optimizing Exogenous Surfactant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2
Q35543287Pro-moieties of antimicrobial peptide prodrugs
Q64986513Vibrating Mesh Nebulisation of Pro-Antimicrobial Peptides for Use in Cystic Fibrosis.

Search more.