Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.

scientific article published on 09 June 2016

Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10295-016-1790-2
P932PMC publication ID4939285
P698PubMed publication ID27277081

P50authorAshootosh TripathiQ55318823
P2093author name stringDavid H Sherman
Eung-Soo Kim
Si-Sun Choi
P2860cites workBiochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide HydrolaseQ27663333
Tolerance and specificity of polyketide synthasesQ28139420
Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.Q33279724
Mining and engineering natural-product biosynthetic pathwaysQ33288081
Exonic splicing signals impose constraints upon the evolution of enzymatic activityQ33635556
Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracisQ33641697
Genetic Contributions to Understanding Polyketide SynthasesQ34114722
Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediatesQ35138927
Structure of a modular polyketide synthaseQ41608053
Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthasesQ42019933
Mechanisms of molecular recognition in the pikromycin polyketide synthaseQ44878838
The Lego-ization of polyketide biosynthesis.Q51358168
Identification and characterization of wblA-dependent tmcT regulation during tautomycetin biosynthesis in Streptomyces sp. CK4412Q84223884
Horizontal gene transfer and gene conversion drive evolution of modular polyketide synthasesQ84242297
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)1189-1193
P577publication date2016-06-09
P1433published inJournal of Industrial Microbiology & BiotechnologyQ1709847
P1476titleThioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412
P478volume43

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cites work (P2860)
Q38979235Biosynthesis, regulation, and engineering of a linear polyketide tautomycetin: a novel immunosuppressant in Streptomyces sp. CK4412.
Q90380911Diversification of polyketide structures via synthase engineering
Q47215208Engineered polyketides: Synergy between protein and host level engineering.
Q92599386Engineering actinomycetes for biosynthesis of macrolactone polyketides
Q58556862Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones
Q96155794Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis
Q97425379Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases
Q38761039Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects

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