| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Ramesh Prasad Pandey | Q48024268 |
| Dipesh Dhakal | Q57555503 | ||
| P2093 | author name string | Jae Kyung Sohng | |
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| Heterologous Biosynthesis of Spinosad: An Omics-Guided Large Polyketide Synthase Gene Cluster Reconstitution in Streptomyces. | Q48159351 | ||
| Improved heterologous erythromycin A production through expression plasmid re-design. | Q50875384 | ||
| Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae. | Q50947457 | ||
| Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes. | Q51044348 | ||
| Engineering of the spinosyn PKS: directing starter unit incorporation. | Q51091211 | ||
| Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin. | Q52356559 | ||
| Doramectin, a new avermectin highly efficacious against gastrointestinal nematodes and lungworms of cattle and pigs: two studies carried out under field conditions in Germany. | Q52544501 | ||
| Expression analysis of the tylosin-biosynthetic gene cluster: pivotal regulatory role of the tylQ product. | Q52545262 | ||
| Discovery, Biosynthesis, and Heterologous Production of Streptoseomycin, an Anti-Microaerophilic Bacteria Macrodilactone. | Q52561850 | ||
| Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation. | Q52677567 | ||
| Biotransformation of rosamicin antibiotic into 10,11-dihydrorosamicin with enhanced in vitro antibacterial activity against MRSA. | Q53314772 | ||
| Regio-selectively reduced streptogramin A analogue, 5,6-dihydrovirginiamycin M1 exhibits improved potency against MRSA. | Q53324322 | ||
| Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities. | Q53404184 | ||
| Biosynthesis of glycosylated derivatives of tylosin in Streptomyces venezuelae. | Q53417910 | ||
| Manipulation of Modular Polyketide Synthases. | Q53673885 | ||
| Application of a new versatile electron transfer system for cytochrome P450-based Escherichia coli whole-cell bioconversions. | Q54320837 | ||
| Effects of NADH kinase on NADPH-dependent biotransformation processes in Escherichia coli. | Q54326023 | ||
| Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus | Q24536090 | ||
| Discovery Strategies of Bioactive Compounds Synthesized by Nonribosomal Peptide Synthetases and Type-I Polyketide Synthases Derived from Marine Microbiomes | Q26752366 | ||
| Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel | Q27636992 | ||
| Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase | Q27652658 | ||
| Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis | Q27681389 | ||
| Genome editing. The new frontier of genome engineering with CRISPR-Cas9 | Q28252298 | ||
| Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster | Q28534635 | ||
| Characterization of a pathway-specific activator of milbemycin biosynthesis and improved milbemycin production by its overexpression in Streptomyces bingchenggensis. | Q30381863 | ||
| Natural-product sugar biosynthesis and enzymatic glycodiversification | Q30492476 | ||
| Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli | Q32075037 | ||
| Combinatorial biosynthesis for drug development | Q33286975 | ||
| Coalition of Biology and Chemistry for Ameliorating Antimicrobial Drug Discovery | Q33634190 | ||
| The beta-lactam antibiotics: past, present, and future | Q33697219 | ||
| Heterologous expression of pikromycin biosynthetic gene cluster using Streptomyces artificial chromosome system | Q33750113 | ||
| Marine Rare Actinobacteria: Isolation, Characterization, and Strategies for Harnessing Bioactive Compounds. | Q33799744 | ||
| Metabolically engineered Escherichia coli for efficient production of glycosylated natural products. | Q33801571 | ||
| Roles of type II thioesterases and their application for secondary metabolite yield improvement | Q34100622 | ||
| Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens | Q34173936 | ||
| Biocatalytic synthesis of pikromycin, methymycin, neomethymycin, novamethymycin, and ketomethymycin | Q42161107 | ||
| An insight into the "-omics" based engineering of streptomycetes for secondary metabolite overproduction | Q42181821 | ||
| Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase | Q42433911 | ||
| Optimizing the heterologous production of epothilone D in Myxococcus xanthus | Q42519433 | ||
| Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates | Q42577561 | ||
| Positive control of tylosin biosynthesis: pivotal role of TylR. | Q54692683 | ||
| CasPER, a method for directed evolution in genomic contexts using mutagenesis and CRISPR/Cas9 | Q56889839 | ||
| Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm? | Q57149935 | ||
| Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products | Q57479721 | ||
| Generation of a cluster-free Streptomyces albus chassis strains for improved heterologous expression of secondary metabolite clusters | Q57994911 | ||
| Recent advances in the discovery and combinatorial biosynthesis of microbial 14-membered macrolides and macrolactones | Q58556862 | ||
| Nystatin-like Pseudonocardia polyene B1, a novel disaccharide-containing antifungal heptaene antibiotic | Q58751665 | ||
| Engineering and modification of microbial chassis for systems and synthetic biology | Q60045721 | ||
| Heterologous expression-facilitated natural products’ discovery in actinomycetes | Q62673366 | ||
| Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline | Q64166981 | ||
| Acyltransferases as Tools for Polyketide Synthase Engineering. | Q64897732 | ||
| Biosynthesis of the macrolide antibiotic tylosin. A preferred pathway from tylactone to tylosin | Q71687635 | ||
| Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases | Q73419416 | ||
| Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase | Q73502930 | ||
| Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea | Q74266942 | ||
| Precursor-directed biosynthesis of 12-ethyl erythromycin | Q77452184 | ||
| Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase | Q77716392 | ||
| New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis | Q78555201 | ||
| Generation of reduced macrolide analogs by regio-specific biotransformation | Q82577823 | ||
| Heterologous expression of galbonolide biosynthetic genes in Streptomyces coelicolor | Q86860683 | ||
| Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli | Q86918456 | ||
| Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives | Q87418269 | ||
| Production of pikromycin using branched chain amino acid catabolism in Streptomyces venezuelae ATCC 15439 | Q88013414 | ||
| Streptomyces species: Ideal chassis for natural product discovery and overproduction | Q88934294 | ||
| Library of Synthetic Streptomyces Regulatory Sequences for Use in Promoter Engineering of Natural Product Biosynthetic Gene Clusters | Q89388065 | ||
| Biosynthesis of Quinolidomicin, the Largest Known Macrolide of Terrestrial Origin: Identification and Heterologous Expression of a Biosynthetic Gene Cluster over 200 kb | Q90447012 | ||
| Heterologous expression of bacterial natural product biosynthetic pathways | Q90939885 | ||
| Extender Unit Promiscuity and Orthogonal Protein Interactions of an Aminomalonyl-ACP Utilizing Trans-Acyltransferase from Zwittermicin Biosynthesis | Q93363943 | ||
| Regulation of the Biosynthesis of the Macrolide Antibiotic Spiramycin in Streptomyces ambofaciens | Q34192714 | ||
| Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586. | Q34200501 | ||
| Genome-scale promoter engineering by coselection MAGE | Q34224602 | ||
| Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10. | Q34335001 | ||
| Polyketide biosynthesis: a millennium review | Q34362914 | ||
| The tylosin-biosynthetic genes of Streptomyces fradiae | Q34510130 | ||
| Natural Products as Sources of New Drugs from 1981 to 2014. | Q34512692 | ||
| Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics | Q34517653 | ||
| Improved precursor-directed biosynthesis in E. coli via directed evolution. | Q34538516 | ||
| Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. | Q34555236 | ||
| Structural basis for macrolactonization by the pikromycin thioesterase | Q34565714 | ||
| Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics | Q34778133 | ||
| Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes | Q34857316 | ||
| Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold | Q35078349 | ||
| Macrolide antibiotics: binding site, mechanism of action, resistance | Q35100800 | ||
| The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. | Q35131209 | ||
| An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strain | Q35748454 | ||
| Minimum Information about a Biosynthetic Gene cluster. | Q35748739 | ||
| Commentary: Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal | Q35856285 | ||
| Engineered biosynthesis of natural products in heterologous hosts | Q35876112 | ||
| Synthetic Biology of Natural Products | Q36098396 | ||
| Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering | Q36254235 | ||
| Tailoring pathway modularity in the biosynthesis of erythromycin analogs heterologously engineered in E. coli | Q36268224 | ||
| Combinatorial biosynthesis of reduced polyketides | Q36328793 | ||
| Taxonomy, Physiology, and Natural Products of Actinobacteria | Q36457919 | ||
| Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae | Q36538915 | ||
| New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters | Q36547378 | ||
| Chemobiosynthesis of new antimalarial macrolides. | Q36558360 | ||
| Reinvigorating natural product combinatorial biosynthesis with synthetic biology | Q36590659 | ||
| Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis. | Q36607621 | ||
| Engineered biosynthesis of a complete macrolactone in a heterologous host | Q36734757 | ||
| Systems biology of antibiotic production by microorganisms | Q37011465 | ||
| Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. | Q37080940 | ||
| Combinatorial biosynthesis of natural products | Q37130405 | ||
| Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering | Q37233243 | ||
| Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production | Q37294579 | ||
| Structural analysis of protein-protein interactions in type I polyketide synthases | Q37352218 | ||
| Microbial drug discovery: 80 years of progress | Q37365189 | ||
| Antitumor compounds from marine actinomycetes | Q37549963 | ||
| Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites | Q37599348 | ||
| Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae | Q37624538 | ||
| Genetic engineering of macrolide biosynthesis: past advances, current state, and future prospects | Q37630380 | ||
| Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster. | Q37671593 | ||
| Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis | Q37721369 | ||
| Synthetic biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production | Q38019704 | ||
| The structures of type I polyketide synthases | Q38031740 | ||
| Engineering of NADPH regenerators in Escherichia coli for enhanced biotransformation | Q38082702 | ||
| Achievements and impacts of glycosylation reactions involved in natural product biosynthesis in prokaryotes. | Q38110187 | ||
| Steps towards the synthetic biology of polyketide biosynthesis | Q38174180 | ||
| Microbial biotransformation of bioactive flavonoids | Q38275162 | ||
| Enhanced production of nargenicin A1 and creation of a novel derivative using a synthetic biology platform. | Q38412598 | ||
| Microbial production of natural and non-natural flavonoids: Pathway engineering, directed evolution and systems/synthetic biology. | Q38416540 | ||
| Enhanced production of nargenicin A(1) and generation of novel glycosylated derivatives. | Q38429805 | ||
| Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A. | Q38474843 | ||
| Iterative polyketide biosynthesis by modular polyketide synthases in bacteria | Q38628326 | ||
| Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology | Q38629855 | ||
| Biosynthesis of polyketides by trans-AT polyketide synthases | Q38675125 | ||
| The Need for Integrated Approaches in Metabolic Engineering. | Q38801055 | ||
| Engineering microbial hosts for production of bacterial natural products | Q38806940 | ||
| Native and engineered promoters in natural product discovery | Q38903306 | ||
| 16-Membered Macrolide Antibiotics: a Review | Q39409087 | ||
| Modular construction of a functional artificial epothilone polyketide pathway | Q39422715 | ||
| Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles | Q39830742 | ||
| Properties of Streptomyces fradiae Mutants Blocked in Biosynthesis of the Macrolide Antibiotic Tylosin | Q39855569 | ||
| Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome | Q39992589 | ||
| Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029. | Q40228174 | ||
| antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification | Q40231155 | ||
| An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain | Q41066742 | ||
| Structural rearrangements of a polyketide synthase module during its catalytic cycle | Q41456081 | ||
| TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli | Q41518576 | ||
| Structure of a modular polyketide synthase | Q41608053 | ||
| Precursor-directed biosynthesis of 6-deoxyerythronolide B analogs in Streptomyces coelicolor: understanding precursor effects | Q41753468 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P433 | issue | 1 | |
| P921 | main subject | macrolides | Q422687 |
| P304 | page(s) | 137 | |
| P577 | publication date | 2019-08-13 | |
| P1433 | published in | Microbial Cell Factories | Q15766995 |
| P1476 | title | Engineering actinomycetes for biosynthesis of macrolactone polyketides | |
| P478 | volume | 18 |
| Q110391622 | Actinobacteria in natural products research: Progress and prospects |
| Q90227921 | Actinomycete-Derived Polyketides as a Source of Antibiotics and Lead Structures for the Development of New Antimicrobial Drugs |
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