Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae

scientific article published on December 2004

Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.48.12.4703-4712.2004
P953full work available at URLhttps://europepmc.org/articles/pmc529187?pdf=render
P932PMC publication ID529187
P698PubMed publication ID15561847

P7228access restriction statusopen accessQ232932
P2093author name stringRalph Reid
Steven D Dong
Christopher D Reeves
Andreas Schirmer
Leonard Katz
Zhihao Hu
W Peter Revill
Oleg V Petrakovsky
Shannon L Ward
P2860cites workA polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetlesQ24540336
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteriaQ27635569
The structures of four macrolide antibiotics bound to the large ribosomal subunitQ27639442
Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.Q31967474
Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.Q33227202
Genes and enzymes involved in deoxysugar biosynthesis in bacteriaQ33683728
Rhamnose biosynthesis pathway supplies precursors for primary and secondary metabolism in Saccharopolyspora spinosaQ33996927
Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergyQ34378672
Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine productionQ34444688
The ketolides: a critical reviewQ34767447
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesisQ34867101
Mechanisms of enzymatic CbondO bond cleavages in deoxyhexose biosynthesisQ34987340
Macrolide antibiotic interaction and resistance on the bacterial ribosomeQ35096318
Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell lineQ36466678
A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversityQ36518025
Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraeaQ36896359
Genetics of Streptomyces fradiae and tylosin biosynthesisQ39548280
The Database of Ribosomal Cross links (DRC).Q39722364
Resistance to macrolides, lincosamides and streptogramin type B antibiotics due to a mutation in an rRNA operon of Streptomyces ambofaciens.Q41090843
Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamineQ41694678
The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.Q42600945
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosaQ42649630
Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraeaQ42668726
Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticusQ42681734
Study of C-4 deoxygenation in the biosynthesis of desosamine: evidence implicating a novel mechanismQ43699980
Relationship of structures and microbiological activities of the 16-membered macrolidesQ43869661
Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin.Q44025296
Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycinQ44170594
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubidaQ44313136
Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.Q44314986
Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene clusterQ44486148
Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae.Q52535030
A chain initiation factor common to both modular and aromatic polyketide synthasesQ60301879
Antimycoplasma activities of macrolide antibioticsQ70395837
GERI-155, a new macrolide antibiotic related to chalcomycinQ71808212
A new 16-membered chalcomycin type macrolide antibiotic, 250-144CQ73147813
Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strainsQ73277195
An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene clusterQ73693997
Chalcomycin B, a New Macrolide Antibiotic from the Marine Isolate Streptomyces sp. B7064.Q78429240
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectStreptomyces fradiaeQ7623383
Streptomyces bikiniensisQ22287015
KLGADJPDTCIJLO-FCNIXBKESA-NQ105142598
P6954online access statusopen accessQ232932
P304page(s)4703-4712
P577publication date2004-12-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleChalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae
P478volume48

Reverse relations

cites work (P2860)
Q27672783A New Structural Form in the SAM/Metal-Dependent O‑Methyltransferase Family: MycE from the Mycinamicin Biosynthetic Pathway
Q52671646A Single Gene Cluster for Chalcomycins and Aldgamycins: Genetic Basis for Bifurcation of Their Biosynthesis.
Q40494065An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products
Q41882561Analysis of the loading and hydroxylation steps in lankamycin biosynthesis in Streptomyces rochei.
Q37549963Antitumor compounds from marine actinomycetes
Q41112288Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway
Q64916664Biosynthesis of Polyketides in Streptomyces.
Q53302757Characterization of Methyltransferase AlmCII in Chalcomycin Biosynthesis: The First TylF Family O-Methyltransferase Works on a 4'-Deoxysugar.
Q37699551Cloning and Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Streptomyces Species
Q37710901Complete genome sequencing and antibiotics biosynthesis pathways analysis of Streptomyces lydicus 103.
Q81430383Deoxy sugars: occurrence and synthesis
Q42378669Dihydrochalcomycin Production and Glycosyltransferase from Streptomyces SP. KCTC 0041BP.
Q92599386Engineering actinomycetes for biosynthesis of macrolactone polyketides
Q38089805Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis
Q46228327Extensive mutational analysis of modular-iterative mixed polyketide biosynthesis of lankacidin in Streptomyces rochei.
Q42110605Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin
Q42625255Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics
Q45269243Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns
Q36676569Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM)
Q28833700Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway
Q37379780Heterologous expression systems for polyketide synthases
Q83638594Heterologous production of polyketides in bacteria
Q52605046Identification and characterization of gerPI and gerPII involved in epoxidation and hydroxylation of dihydrochalcolactone in Streptomyces species KCTC 0041BP.
Q28486930Identification of the missing trans-acting enoyl reductase required for phthiocerol dimycocerosate and phenolglycolipid biosynthesis in Mycobacterium tuberculosis
Q34331635Imaging secondary metabolism of Streptomyces sp. Mg1 during cellular lysis and colony degradation of competing Bacillus subtilis.
Q34049173In-silico and In-vitro based studies of Streptomyces peucetius CYP107N3 for oleic acid epoxidation
Q37814157Natural glycoconjugates with antitumor activity
Q30492476Natural-product sugar biosynthesis and enzymatic glycodiversification
Q39018273Pantoea ananatis: genomic insights into a versatile pathogen
Q37831207Strain improvement in actinomycetes in the postgenomic era.
Q37751993Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters
Q33243837Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42.
Q35612402Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases.
Q27657980The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily
Q46773244The DEBS paradigm for type I modular polyketide synthases and beyond
Q39231472The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines
Q38141851The role of transcription in heterologous expression of polyketides in bacterial hosts.

Search more.