TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli

scientific article published on 23 April 2010

TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AEM.03083-09
P932PMC publication ID2893496
P698PubMed publication ID20418422

P2093author name stringHugo Gramajo
John R Carney
Guillermo R Labadie
Eduardo Rodríguez
Salvador Peirú
Mariana Useglio
P2860cites workAknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.Q38325948
Antiparasitic effects of the intra-Golgi transport inhibitor megalomicinQ39559177
Production of the potent antibacterial polyketide erythromycin C in Escherichia coliQ40425373
Megalomicin inhibits HIV-1 replication and interferes with gp160 processingQ41071206
Megalomicin disrupts lysosomal functionsQ41096000
The role of carbohydrates in biologically active natural productsQ41468708
Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.Q44909083
Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesisQ45196753
The megalomicins. Part V. Mass spectral studiesQ54127976
Characterization of the heterodimeric MegBIIa:MegBIIb aldo-keto reductase involved in the biosynthesis of L-mycarose from Micromonospora megalomicea.Q54439655
The megalomicins. Part IV. The structures of megalomicins A, B, C1, and C2Q69696791
Megalomicin, a new macrolide antibiotic complex produced by MicromonosporaQ72483969
Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraeaQ74266942
In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolidesQ24657200
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0Q26778434
Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesisQ28344862
Characterization and investigation of substrate specificity of the sugar aminotransferase WecE from E. coli K12.Q33205141
Metabolically engineered Escherichia coli for efficient production of glycosylated natural products.Q33801571
Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamineQ34138957
In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.Q34499313
Megalomycin C, a macrolide antibiotic that blocks protein glycosylation and shows antiviral activityQ34554111
Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementationQ34574869
Biochemical characterization of dTDP-D-Qui4N and dTDP-D-Qui4NAc biosynthetic pathways in Shigella dysenteriae type 7 and Escherichia coli O7.Q34695635
The impact of enzyme engineering upon natural product glycodiversificationQ34803952
Enzymatic tools for engineering natural product glycosylation.Q36468505
Engineering the glycosylation of natural products in actinomycetesQ36782462
Intra-Golgi transport inhibition by megalomicin.Q36799181
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
P304page(s)3869-3877
P577publication date2010-04-23
P1433published inApplied and Environmental MicrobiologyQ4781593
P1476titleTDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli
P478volume76

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cites work (P2860)
Q36558360Chemobiosynthesis of new antimalarial macrolides.
Q92599386Engineering actinomycetes for biosynthesis of macrolactone polyketides
Q58772177Enzymatic Synthesis of the C-Glycosidic Moiety of Nogalamycin R
Q37340715Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules
Q38578677Glycosyltransferases: mechanisms and applications in natural product development
Q51069123New insights into polyene macrolide biosynthesis in Couchioplanes caeruleus.
Q127060107OSMAC Method to Assess Impact of Culture Parameters on Metabolomic Diversity and Biological Activity of Marine-Derived Actinobacteria
Q123351297Prioritization of Microorganisms Isolated from the Indian Ocean Sponge Scopalina hapalia Based on Metabolomic Diversity and Biological Activity for the Discovery of Natural Products
Q24633331Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII
Q57016865Synthetic Biology of Antibiotic Production

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