The role of FilGAP-filamin A interactions in mechanoprotection

scientific article published on 14 January 2009

The role of FilGAP-filamin A interactions in mechanoprotection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E08-08-0872
P932PMC publication ID2649276
P698PubMed publication ID19144823

P2093author name stringChristopher A McCulloch
David A Calderwood
Yasutaka Ohta
Yulia Shifrin
Pamela D Arora
P2860cites workThe small GTPase RalA targets filamin to induce filopodiaQ22008839
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodellingQ24297925
Rho GTPases and the actin cytoskeletonQ27860579
Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.Q27919621
Structural and functional aspects of filaminsQ28187219
Cortactin: coupling membrane dynamics to cortical actin assemblyQ28199365
Filamins as integrators of cell mechanics and signallingQ28205076
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formationQ28206691
Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaBQ28216113
Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1Q28219213
Integrins in mechanotransductionQ28244898
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cellsQ28302003
Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignmentQ28348367
Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathwayQ28566405
Effects of cell tension on the small GTPase RacQ28568393
Small GTP-binding proteinsQ29547372
The Ras superfamily at a glanceQ29617344
Cooperative effects of Rho and mechanical stretch on stress fiber organizationQ30446661
Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression.Q30453215
Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometryQ30478880
Distinct membrane mechanical properties of human mesenchymal stem cells determined using laser optical tweezersQ30806176
NO protects alveolar type II cells from stretch-induced apoptosis. A novel role for macrophages in the lungQ31558739
Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffnessQ33340920
The structural and mechanical complexity of cell-growth controlQ33772662
Focal adhesions - the cytoskeletal connectionQ33840319
The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actinQ33930483
Suppression of Ras-induced apoptosis by the Rac GTPaseQ33959056
Mechanotransduction across the cell surface and through the cytoskeletonQ34306171
Stretch-induced programmed myocyte cell deathQ35766096
Mechanotransduction at cell-matrix and cell-cell contactsQ35837614
The many faces of filamin: a versatile molecular scaffold for cell motility and signallingQ35934200
Overview of ventilator-induced lung injury mechanisms.Q36014203
Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress responseQ36385575
Filamins: promiscuous organizers of the cytoskeletonQ36510058
Actin polymerization and intracellular solvent flow in cell surface blebbingQ36535754
Cytoprotection against mechanical forces delivered through beta 1 integrins requires induction of filamin A.Q38299547
Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides productionQ38491199
Pressure-induced arterial wall stress and atherosclerosisQ40539857
Recovery from DNA damage-induced G2 arrest requires actin-binding protein filamin-A/actin-binding protein 280.Q40609753
Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factorQ40703140
Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forcesQ40742956
Activation of the RacGTPase inhibits apoptosis in human tumor cellsQ40775778
Anti-apoptotic function of Rac in hematopoietic cells.Q40976654
Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway.Q41002093
The role of actin-binding protein 280 in integrin-dependent mechanoprotectionQ41069999
The cellular and molecular response of cardiac myocytes to mechanical stress.Q41388060
Loss, restoration, and maintenance of plasma membrane integrityQ41432538
Role of integrins in cellular responses to mechanical stress and adhesionQ41612571
Actin-binding protein requirement for cortical stability and efficient locomotionQ41643536
A new method for application of force to cells via ferric oxide beadsQ41651179
Effects of mechanical forces on signal transduction and gene expression in endothelial cellsQ41695590
Model of coupled transient changes of Rac, Rho, adhesions and stress fibers alignment in endothelial cells responding to shear stressQ42471564
Rapid induction and isolation of focal adhesion complexesQ42483319
The molecular basis of filamin binding to integrins and competition with talinQ42805546
Rac1 prevents cisplatin-induced apoptosis through down-regulation of p38 activation in NIH3T3 cells.Q42815640
Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosisQ42819041
Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinasesQ42917027
Mechanical stress increases RhoA activation in airway smooth muscle cellsQ44374308
Increased stromelysin-1 (MMP-3), proteoglycan degradation (3B3- and 7D4) and collagen damage in cyclically load-injured articular cartilageQ47627328
In situ detection of apoptosis during embryogenesis with annexin V: from whole mount to ultrastructure.Q52191302
Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress.Q52520253
Magnetic fields applied to collagen-coated ferric oxide beads induce stretch-activated Ca2+ flux in fibroblastsQ71569052
The carboxy-terminal pleckstrin homology domain of ROCK interacts with filamin-AQ73009469
Calcium ions and tyrosine phosphorylation interact coordinately with actin to regulate cytoprotective responses to stretchingQ73018227
Force-induced osteoclast apoptosis in vivo is accompanied by elevation in transforming growth factor beta and osteoprotegerin expressionQ73069646
Generation of deletion and point mutations with one primer in a single cloning stepQ73206310
Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-AQ77221552
Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migrationQ80919123
P4510describes a project that usesImageJQ1659584
P433issue5
P304page(s)1269-1279
P577publication date2009-01-14
P1433published inMolecular Biology of the CellQ2338259
P1476titleThe role of FilGAP-filamin A interactions in mechanoprotection
P478volume20

Reverse relations

cites work (P2860)
Q38608946ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing
Q42952495Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.
Q42176707Cellular mechanotransduction: filamin A strains to regulate motility
Q34662242Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells
Q36999018Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve
Q41428426Diverse phenotypic consequences of mutations affecting the C-terminus of FLNA.
Q36824474Domain-domain interactions in filamin A (16-23) impose a hierarchy of unfolding forces
Q99619292FLN-1/Filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue
Q30392606FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans
Q38114125FilGAP and its close relatives: a mediator of Rho-Rac antagonism that regulates cell morphology and migration
Q35755363FilGAP, a Rac-specific Rho GTPase-activating protein, is a novel prognostic factor for follicular lymphoma
Q30529774FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration
Q42098426Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix
Q27333875Filamin A-hinge region 1-EGFP: a novel tool for tracking the cellular functions of filamin A in real-time
Q48220223Filamin C plays an essential role in the maintenance of the structural integrity of cardiac and skeletal muscles, revealed by the medaka mutant zacro.
Q27322806Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca
Q30402039Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?
Q33900830Filamins in mechanosensing and signaling
Q27335443Filamins regulate cell spreading and initiation of cell migration
Q42795953Force-induced apoptosis mediated by the Rac/Pak/p38 signalling pathway is regulated by filamin A.
Q38116705Integrins in mechanotransduction
Q38880148Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
Q63408491Mechanisms and impact of altered tumour mechanics
Q35432698Mechano-transduction: from molecules to tissues
Q42080692Modeling the Mechanosensitivity of Neutrophils Passing through a Narrow Channel
Q33583554N-terminal strands of filamin Ig domains act as a conformational switch under biological forces
Q30360988PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility.
Q37475550Phosphorylation facilitates the integrin binding of filamin under force
Q38836141Phosphorylation of Serine 402 Regulates RacGAP Protein Activity of FilGAP Protein
Q30596295Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation.
Q38196358Regulation of the endothelial barrier function: a filum granum of cellular forces, Rho-GTPase signaling and microenvironment.
Q30539318Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.
Q26992281Rho GAPs and GEFs: controling switches in endothelial cell adhesion
Q38224569Rho GTPases: masters of cell migration
Q39084479Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction.
Q47820974Signaling by Small GTPases at Cell-Cell junctions: Protein Interactions Building Control and Networks.
Q35890184Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM10.
Q39863533The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling
Q37268466The effects of cytotoxic necrotizing factor 1 expression in the uptake of Escherichia coli K1 by macrophages and the onset of meningitis in newborn mice.
Q34891266The filamins: organizers of cell structure and function
Q26825105The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration
Q38735665The role of FilGAP, a Rac-specific Rho-GTPase-activating protein, in tumor progression and behavior of astrocytomas
Q91729090The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

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