Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini

scientific article published on 24 December 2008

Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M807842200
P932PMC publication ID2652276
P698PubMed publication ID19110481

P2093author name stringSharon L Campbell
Michael D Schaller
Martin P Playford
Susan W Craig
Sean M Palmer
P2860cites workF-actin binding site masked by the intramolecular association of vinculin head and tail domainsQ24309102
Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphateQ42812246
Conformational change in the vinculin C-terminal depends on a critical histidine residue (His-906).Q43624034
Three-dimensional structure of vinculin bound to actin filamentsQ44718700
Structural basis for vinculin activation at sites of cell adhesion.Q44934819
Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathyQ46763552
Crystal structure of human vinculinQ47227024
A conserved motif in the tail domain of vinculin mediates association with and insertion into acidic phospholipid bilayersQ47838828
The carboxy-terminal tail domain of vinculin contains a cryptic binding site for acidic phospholipidsQ49270032
A Pleckstrin Homology Domain Specific for Phosphatidylinositol 4,5-Bisphosphate (PtdIns-4,5-P2) and Fused to Green Fluorescent Protein Identifies Plasma Membrane PtdIns-4,5-P2as Being Important in ExocytosisQ56689853
Role of vinculin in regulating focal adhesion turnoverQ60227714
Purification and characterization of an 85 kDa talin-binding fragment of vinculinQ67266976
Molecular shape and self-association of vinculin and metavinculinQ69969265
Diversity of vinculin/meta-vinculin in human tissues and cultivated cells. Expression of muscle specific variants of vinculin in human aorta smooth muscle cellsQ70385761
The ultrastructure of chicken gizzard vinculin as visualized by high-resolution electron microscopyQ71545242
An intramolecular association between the head and tail domains of vinculin modulates talin bindingQ72403447
Actin activates a cryptic dimerization potential of the vinculin tail domainQ73316721
Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cellsQ74344711
Integrins in regulation of tissue development and functionQ79334879
Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated discQ80204091
A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathyQ83377734
Backbone 1H, 13C, and 15N NMR assignments of the tail domain of vinculinQ84303230
Crystal structure of the vinculin tail suggests a pathway for activationQ27620822
Structure of the Dimerization and β-Catenin- Binding Region of α-CateninQ27625229
Vinculin activation by talin through helical bundle conversionQ27642883
Cell migration: integrating signals from front to backQ27860670
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
NMR View: A computer program for the visualization and analysis of NMR dataQ27860951
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formationQ28139699
Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathyQ28244992
A vinculin-containing cortical lattice in skeletal muscle: transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemmaQ28267917
Spatial distribution and functional significance of activated vinculin in living cellsQ28591795
Integrin signalling in directed cell migration.Q30441276
Vinculin controls focal adhesion formation by direct interactions with talin and actin.Q30441610
A lipid-regulated docking site on vinculin for protein kinase C.Q30777845
Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotionQ33889491
Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formationQ34108948
Modular phosphoinositide-binding domains--their role in signalling and membrane trafficking.Q34429734
Vinculin knockout results in heart and brain defects during embryonic development.Q34458643
PIP(2) and proteins: interactions, organization, and information flowQ34623576
Phosphoinositide regulation of the actin cytoskeletonQ35019759
Heterozygous inactivation of the vinculin gene predisposes to stress-induced cardiomyopathyQ35103087
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosisQ36293644
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.Q36322135
The relationship between force and focal complex developmentQ36323790
Vinculin, an intracellular protein localized at specialized sites where microfilament bundles terminate at cell membranesQ36398107
Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNAQ36531986
Vinculin is essential for muscle function in the nematodeQ36532718
The structure and regulation of vinculin.Q36558847
Integrins and the actin cytoskeletonQ36690530
Cell motility and cytoskeletal regulation in invasion and metastasisQ36844181
Cell-matrix adhesionQ36902965
Coincidence of actin filaments and talin is required to activate vinculinQ40214103
Vinculin acts as a sensor in lipid regulation of adhesion-site turnover.Q40446353
Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin.Q40454932
Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculinQ41044503
Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sitesQ41789701
Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility, and anchorage-dependent growth of 3T3 cells.Q42085008
Polyphosphoinositides inhibit the interaction of vinculin with actin filamentsQ42603817
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)7223-7231
P577publication date2008-12-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleLipid binding to the tail domain of vinculin: specificity and the role of the N and C termini
P478volume284

Reverse relations

cites work (P2860)
Q27661932A Helix Replacement Mechanism Directs Metavinculin Functions
Q50025378A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization
Q51713302Alteration of transbilayer phospholipid compositions is involved in cell adhesion, cell spreading, and focal adhesion formation.
Q42053236Binding of Vinculin to Lipid Membranes in Its Inhibited and Activated States
Q37213739Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization
Q41230015Effects of substrate stiffness and actomyosin contractility on coupling between force transmission and vinculin-paxillin recruitment at single focal adhesions.
Q42209607How far in-silico computing meets real experiments. A study on the structure and dynamics of spin labeled vinculin tail protein by molecular dynamics simulations and EPR spectroscopy
Q30405334Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties
Q39938242Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis
Q34656849Lipid binding promotes oligomerization and focal adhesion activity of vinculin
Q38265394Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites
Q34036028Monomeric and dimeric conformation of the vinculin tail five-helix bundle in solution studied by EPR spectroscopy
Q47136381Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway
Q36742744Novel role for vinculin in ventricular myocyte mechanics and dysfunction.
Q27684765Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes
Q42336468Phosphoinositide Binding Inhibits Actin Crosslinking and Polymerization by Palladin
Q35119240Phosphoinositides in cell architecture.
Q97541097Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin
Q41890872Phosphorylation at Y1065 in vinculin mediates actin bundling, cell spreading, and mechanical responses to force.
Q35926233Phosphorylation primes vinculin for activation
Q27003285Putative biomarkers and targets of estrogen receptor negative human breast cancer
Q37677924Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides
Q36748018Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
Q27681225The Metavinculin Tail Domain Directs Constitutive Interactions with Raver1 and vinculin RNA
Q34697750The interaction of vinculin with actin.
Q35639727The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties
Q27009352Vinculin and metavinculin: oligomerization and interactions with F-actin
Q28592273Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes
Q37563556Vinculin phosphorylation at Tyr1065 regulates vinculin conformation and tension development in airway smooth muscle tissues
Q37636945Vinculin regulation of F-actin bundle formation: what does it mean for the cell?
Q35565750Vinculin-dependent actin bundling regulates cell migration and traction forces.
Q47713707α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion.

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