Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

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Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes is …
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scholarly articleQ13442814

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P819ADS bibcode2014PNAS..111E3177G
P356DOI10.1073/PNAS.1317022111
P3181OpenCitations bibliographic resource ID2837857
P932PMC publication ID4128148
P698PubMed publication ID25049397
P5875ResearchGate publication ID264125965

P50authorCarolina EpifanoQ58598650
Daniel LiethaQ30158438
Mirna Perez-MorenoQ37646646
Frauke GräterQ40933977
Francesco Luigi GervasioQ54665519
Leonor KremerQ56154048
Jasminka BoskovicQ56810508
P2093author name stringJing Zhou
Michael J Eck
M Teresa Martín
Marta Camacho-Artacho
Agnieszka Bronowska
Guillermina M Goñi
P2860cites workIntegrin-dependent control of inositol lipid synthesis in vascular endothelial cells and smooth muscle cellsQ71033955
Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibitionQ24297931
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinasesQ24306594
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substratesQ24324381
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motilityQ24338202
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60srcQ24614033
Structural basis for the autoinhibition of focal adhesion kinaseQ24678318
Mechanosensitivity and compositional dynamics of cell-matrix adhesionsQ26849684
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillinQ27637397
The structural basis of localization and signaling by the focal adhesion targeting domainQ27638962
NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding modelQ27642755
FAK dimerization controls its kinase-dependent functions at focal adhesionsQ27681534
Cell signaling by receptor tyrosine kinasesQ27860474
Alternative splicing controls the mechanisms of FAK autophosphorylationQ28118951
FAK integrates growth-factor and integrin signals to promote cell migrationQ28144169
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talinQ28214335
Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesionsQ28214350
Nanoscale architecture of integrin-based cell adhesionsQ28299215
Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesionQ28508195
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient miceQ29617498
Focal adhesion kinase as a regulator of cell tension in the progression of cancerQ30440310
Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic interventionQ30445536
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasionQ30445760
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for CrkQ30452729
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.Q30495320
Focal adhesion kinase is involved in mechanosensing during fibroblast migrationQ33944467
Molecular complexity and dynamics of cell-matrix adhesionsQ34438160
Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.Q34948215
Focal adhesion kinase stabilizes the cytoskeleton.Q35512646
Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migrationQ36118826
Evolution of the eukaryotic protein kinases as dynamic molecular switchesQ36153870
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout miceQ36638658
Visualizing and manipulating focal adhesion kinase regulation in live cellsQ36724913
Lipid binding to the tail domain of vinculin: specificity and the role of the N and C terminiQ37119768
Coarse-grained modeling of allosteric regulation in protein receptorsQ37321069
Signal transduction by focal adhesion kinase in cancerQ37377635
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functionsQ37717830
Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancerQ37750751
The FERM domain: organizing the structure and function of FAK.Q37802193
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesisQ37813854
Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesisQ39938242
Spatial and temporal regulation of focal adhesion kinase activity in living cells.Q40060648
Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interactionQ40172193
Structural basis for the autoinhibition of talin in regulating integrin activationQ42410877
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.Q42615205
Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cellsQ44053770
Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnoverQ46171629
Pre-steady-state kinetic analysis of cAMP-dependent protein kinase using rapid quench flow techniquesQ46651487
P4510describes a project that usesImageJQ1659584
P433issue31
P407language of work or nameEnglishQ1860
P304page(s)E3177-86
P577publication date2014-08-05
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePhosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes
P478volume111