Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis

scientific article published on 17 June 2013

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.00438-13
P932PMC publication ID3753904
P698PubMed publication ID23775120

P2093author name stringTing-Fang Wang
Chi-Ning Chuang
Yun-Hsin Cheng
Feng-Ming Lin
Hui-Ju Shen
P2860cites workFrequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosisQ21092719
SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiaeQ24681493
The meiosis-specific zip4 protein regulates crossover distribution by promoting synaptonemal complex formation together with zip2.Q27929737
Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombinationQ27929793
Meiotic chromosomes: it takes two to tangoQ27930023
CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpointQ27930799
A Role for SUMO in meiotic chromosome synapsisQ27931422
A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis.Q27931673
The budding yeast Msh4 protein functions in chromosome synapsis and the regulation of crossover distributionQ27931846
The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeastQ27932800
DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progressionQ27933115
Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formationQ27933968
Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosisQ27934346
Zip2, a meiosis-specific protein required for the initiation of chromosome synapsisQ27934770
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.Q27934937
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.Q27934939
NDT80, a meiosis-specific gene required for exit from pachytene in Saccharomyces cerevisiaeQ27935026
Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choiceQ27935546
A Mec1- and PP4-dependent checkpoint couples centromere pairing to meiotic recombinationQ27935744
A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpointQ27936045
Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsisQ27936223
Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeastQ27936239
Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombinationQ27936736
Polo-like kinase Cdc5 drives exit from pachytene during budding yeast meiosisQ27936840
Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosisQ27936900
Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination.Q27938325
The transcriptional program of sporulation in budding yeastQ27938344
Zip3 provides a link between recombination enzymes and synaptonemal complex proteinsQ27939710
Differential timing and control of noncrossover and crossover recombination during meiosisQ28207440
DNA double-strand breaks in meiosis: checking their formation, processing and repairQ28246052
Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labelingQ28768890
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageQ29614218
Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombinationQ29615272
ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsisQ29618281
DNA helicase Srs2 disrupts the Rad51 presynaptic filamentQ29618305
The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombinationQ29618523
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeastQ29618612
Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeastQ29976896
Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1.Q30827295
Acquisition of inhibitor-sensitive protein kinases through protein designQ33716168
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.Q33863002
The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates.Q33938817
Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.Q33953047
Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeastQ34014307
The pachytene checkpointQ34023299
Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1.Q34148240
A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegansQ34474546
Genetic Evidence That Polysumoylation Bypasses the Need for a SUMO-Targeted Ub LigaseQ34477461
Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiaeQ34608894
Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.Q34742310
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.Q34841266
The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replicationQ34985764
Prelude to a divisionQ35619405
The genetics and molecular biology of the synaptonemal complex.Q35912834
BLM ortholog, Sgs1, prevents aberrant crossing-over by suppressing formation of multichromatid joint moleculesQ36082370
Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathwayQ36178621
Mek1 stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during yeast meiosisQ36478038
Global analysis of SUMO chain function reveals multiple roles in chromatin regulationQ36732737
Role of the Saccharomyces cerevisiae Rad53 checkpoint kinase in signaling double-strand breaks during the meiotic cell cycleQ36748090
Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM.Q36900909
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1.Q37301087
Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaksQ37358029
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanismQ39896119
Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylationQ42088017
Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpointQ42142499
Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligaseQ42180908
Sister cohesion and structural axis components mediate homolog bias of meiotic recombinationQ42589701
Evidence that MEK1 positively promotes interhomologue double-strand break repairQ42702326
Two distinct surveillance mechanisms monitor meiotic chromosome metabolism in budding yeastQ42775595
ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.Q44079733
The SUMO isopeptidase Ulp2 prevents accumulation of SUMO chains in yeastQ44564184
The Sgs1 Helicase Regulates Chromosome Synapsis and Meiotic Crossing OverQ47388021
Imposition of crossover interference through the nonrandom distribution of synapsis initiation complexesQ47910491
Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.Q51962360
Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis.Q53609546
THE LEPTOTENE-ZYGOTENE TRANSITION OF MEIOSISQ56136641
Intermediates of Yeast Meiotic Recombination Contain Heteroduplex DNAQ58486283
A meiotic recombination checkpoint controlled by mitotic checkpoint genesQ59098626
Spo11-accessory proteins link double-strand break sites to the chromosome axis in early meiotic recombinationQ64386697
A DNA damage response pathway controlled by Tel1 and the Mre11 complexQ64388109
B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosisQ64388227
Identification of joint molecules that form frequently between homologs but rarely between sister chromatids during yeast meiosisQ64389750
MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repairQ71919357
Regulation of meiotic S phase by Ime2 and a Clb5,6-associated kinase in Saccharomyces cerevisiaeQ77319700
Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiaeQ86714300
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)3365-3376
P577publication date2013-06-17
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThree distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis
P478volume33

Reverse relations

cites work (P2860)
Q91559728A lncRNA coordinates with Ezh2 to inhibit HIF-1α transcription and suppress cancer cell adaption to hypoxia
Q97519370ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination in Arabidopsis
Q35921916Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair
Q47684827Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.
Q38239320Homeostatic regulation of meiotic DSB formation by ATM/ATR.
Q37499591Pch2 prevents Mec1/Tel1-mediated Hop1 phosphorylation occurring independently of Red1 in budding yeast meiosis
Q35754808Reduced Crossover Interference and Increased ZMM-Independent Recombination in the Absence of Tel1/ATM.
Q36701066S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.
Q34248122The meiotic checkpoint network: step-by-step through meiotic prophase

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