Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.

scientific article published in March 2008

Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2008.01.035
P698PubMed publication ID18329363
P5875ResearchGate publication ID5523623

P50authorRita S. ChaQ51661449
P2093author name stringJesús A Carballo
Steven G Sedgwick
Anthony L Johnson
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)758-770
P577publication date2008-03-01
P1433published inCellQ655814
P1476titlePhosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination.
P478volume132

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cites work (P2860)
Q60908009A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
Q57793791A chromatin-associated protein required for inducing and limiting meiotic DNA double-strand break formation
Q61446381A conserved filamentous assembly underlies the structure of the meiotic chromosome axis
Q33504549A high throughput genetic screen identifies new early meiotic recombination functions in Arabidopsis thaliana
Q34514500A method for sporulating budding yeast cells that allows for unbiased identification of kinase substrates using stable isotope labeling by amino acids in cell culture.
Q38243395A non-sister act: recombination template choice during meiosis
Q35156707A quality control mechanism coordinates meiotic prophase events to promote crossover assurance
Q97519370ATM Promotes RAD51-Mediated Meiotic DSB Repair by Inter-Sister-Chromatid Recombination in Arabidopsis
Q21145047ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes
Q98161266ATR Signaling in Mammalian Meiosis: From Upstream Scaffolds to Downstream Signaling
Q37019209ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing
Q55506171ATR is a multifunctional regulator of male mouse meiosis.
Q55505997ATR is required to complete meiotic recombination in mice.
Q37208603ATR/Mec1 prevents lethal meiotic recombination initiation on partially replicated chromosomes in budding yeast.
Q47594999Affinity proteomics reveals extensive phosphorylation of the Brassica chromosome axis protein ASY1 and a network of associated proteins at prophase I of meiosis.
Q34487215An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control.
Q35683573Analysis of the Relationships between DNA Double-Strand Breaks, Synaptonemal Complex and Crossovers Using the Atfas1-4 Mutant
Q52443651Are the effects of elevated temperature on meiotic recombination and thermotolerance linked via the axis and synaptonemal complex?
Q27930407Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1
Q27932605Budding Yeast SLX4 Contributes to the Appropriate Distribution of Crossovers and Meiotic Double-Strand Break Formation on Bivalents During Meiosis
Q34795521Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery.
Q35921916Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair
Q46160152Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2.
Q42119369Contrasting roles of checkpoint proteins as recombination modulators at Fob1-Ter complexes with or without fork arrest
Q57179283Control of meiotic double-strand-break formation by ATM: local and global views
Q48177373Coordination of Double Strand Break Repair and Meiotic Progression in Yeast by a Mek1-Ndt80 Negative Feedback Loop.
Q36942440Crossovers trigger a remodeling of meiotic chromosome axis composition that is linked to two-step loss of sister chromatid cohesion
Q27931634Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis
Q30884204Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast
Q35898808DNA damage response clamp 9-1-1 promotes assembly of ZMM proteins for formation of crossovers and synaptonemal complex
Q34931255DNA strand exchange and RecA homologs in meiosis
Q27934547Differential association of the conserved SUMO ligase Zip3 with meiotic double-strand break sites reveals regional variations in the outcome of meiotic recombination
Q36311155Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans.
Q34244927Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.
Q37311491Distribution of meiotic recombination events: talking to your neighbors
Q27324663Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor
Q41825330Down-regulation of Rad51 activity during meiosis in yeast prevents competition with Dmc1 for repair of double-strand breaks
Q45416294Effects of XRCC2 and RAD51B mutations on somatic and meiotic recombination in Arabidopsis thaliana
Q35725882Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1
Q21092719Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis
Q54977503Functional Impact of the H2A.Z Histone Variant During Meiosis in Saccharomyces cerevisiae.
Q53331688Functional interactions among members of the meiotic initiation complex in fission yeast.
Q48149888Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis
Q35221514Genetic evidence that synaptonemal complex axial elements govern recombination pathway choice in mice
Q52351581Genetic interactions between the chromosome axis-associated protein Hop1 and homologous recombination determinants in Schizosaccharomyces pombe.
Q34742310Genetic requirements and meiotic function of phosphorylation of the yeast axial element protein Red1.
Q37669186Genetics of mammalian meiosis: regulation, dynamics and impact on fertility
Q28649852Gradual implementation of the meiotic recombination program via checkpoint pathways controlled by global DSB levels
Q58696735HO Endonuclease-Initiated Recombination in Yeast Meiosis Fails To Promote Homologous Centromere Pairing and Is Not Constrained To Utilize the Dmc1 Recombinase
Q28594947HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes
Q28594068HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity
Q47684827Histone H3 Threonine 11 Phosphorylation Is Catalyzed Directly by the Meiosis-Specific Kinase Mek1 and Provides a Molecular Readout of Mek1 Activity in Vivo.
Q38239320Homeostatic regulation of meiotic DSB formation by ATM/ATR.
Q27345390Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis
Q36026803Identification of Putative Mek1 Substrates during Meiosis in Saccharomyces cerevisiae Using Quantitative Phosphoproteomics
Q42316656Impact of histone H4K16 acetylation on the meiotic recombination checkpoint in Saccharomyces cerevisiae
Q57112790Impeding DNA Break Repair Enables Oocyte Quality Control
Q42917873Inhibition of the Smc5/6 complex during meiosis perturbs joint molecule formation and resolution without significantly changing crossover or non-crossover levels.
Q37362826Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis
Q27336045Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis
Q35530032Juxtaposition of heterozygous and homozygous regions causes reciprocal crossover remodelling via interference during Arabidopsis meiosis
Q37574327Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis.
Q48256770Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes.
Q34931212Mechanism and regulation of meiotic recombination initiation
Q28592420Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice
Q28585141Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms
Q28069368Meiotic DSB patterning: A multifaceted process
Q27940335Meiotic crossover control by concerted action of Rad51-Dmc1 in homolog template bias and robust homeostatic regulation
Q35541520Meiotic functions of RAD18.
Q28594654Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.
Q27937705Mek1 Down Regulates Rad51 Activity during Yeast Meiosis by Phosphorylation of Hed1
Q60310762Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80
Q34340732Mek1 kinase governs outcomes of meiotic recombination and the checkpoint response
Q36478038Mek1 stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during yeast meiosis
Q33975345Mek1 suppression of meiotic double-strand break repair is specific to sister chromatids, chromosome autonomous and independent of Rec8 cohesin complexes
Q28586590Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase
Q33826136Mouse HORMAD1 is a meiosis i checkpoint protein that modulates DNA double- strand break repair during female meiosis
Q34558046Multiple opposing constraints govern chromosome interactions during meiosis
Q41875887Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1.
Q27936069Pch2 acts through Xrs2 and Tel1/ATM to modulate interhomolog bias and checkpoint function during meiosis
Q27934512Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1
Q33486503Pch2 links chromosome axis remodeling at future crossover sites and crossover distribution during yeast meiosis
Q35222734Pch2 modulates chromatid partner choice during meiotic double-strand break repair in Saccharomyces cerevisiae.
Q37499591Pch2 prevents Mec1/Tel1-mediated Hop1 phosphorylation occurring independently of Red1 in budding yeast meiosis
Q38431480Pch2(TRIP13): controlling cell division through regulation of HORMA domains
Q64096730Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes
Q37499545Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae.
Q34162317Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis
Q35872885Phosphorylation of the Synaptonemal Complex Protein Zip1 Regulates the Crossover/Noncrossover Decision during Yeast Meiosis
Q33653455Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop
Q37058652Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR).
Q37485516Prevention of DNA Rereplication Through a Meiotic Recombination Checkpoint Response
Q90883934Principles of meiotic chromosome assembly revealed in S. cerevisiae
Q39155608Prophase I: Preparing Chromosomes for Segregation in the Developing Oocyte
Q53262517Rec10- and Rec12-independent recombination in meiosis of Schizosaccharomyces pombe.
Q28262099Recombination, Pairing, and Synapsis of Homologs during Meiosis
Q37289048Recombinogenic conditions influence partner choice in spontaneous mitotic recombination.
Q35754808Reduced Crossover Interference and Increased ZMM-Independent Recombination in the Absence of Tel1/ATM.
Q41327161Reduced dosage of the chromosome axis factor Red1 selectively disrupts the meiotic recombination checkpoint in Saccharomyces cerevisiae
Q90044520Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
Q36748090Role of the Saccharomyces cerevisiae Rad53 checkpoint kinase in signaling double-strand breaks during the meiotic cell cycle
Q37769457Role of ubiquitination in meiotic recombination repair
Q33725455Roles of Hop1 and Mek1 in meiotic chromosome pairing and recombination partner choice in Schizosaccharomyces pombe
Q36529251S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.
Q36701066S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.
Q91871060S. cerevisiae Srs2 helicase ensures normal recombination intermediate metabolism during meiosis and prevents accumulation of Rad51 aggregates
Q84564246SUMOylation is required for normal development of linear elements and wild-type meiotic recombination in Schizosaccharomyces pombe
Q50928315Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end-joining activity and potentiates Hop1-promoted pairing of double-stranded DNA.
Q27317410Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions
Q39412683Synaptonemal Complex Components Are Required for Meiotic Checkpoint Function in Caenorhabditis elegans
Q33953047Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.
Q55432533Tackling Plant Meiosis: From Model Research to Crop Improvement.
Q37560589Taming the tiger by the tail: modulation of DNA damage responses by telomeres
Q53659612Tel1(ATM)-mediated interference suppresses clustered meiotic double-strand-break formation.
Q90300212The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis
Q95831637The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes
Q36218780The Chromosome Axis Mediates Feedback Control of CHK-2 to Ensure Crossover Formation in C. elegans
Q47899203The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.
Q36631422The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species
Q35962395The MRX Complex Ensures NHEJ Fidelity through Multiple Pathways Including Xrs2-FHA-Dependent Tel1 Activation
Q34620846The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.
Q41117313The Pch2 AAA+ ATPase promotes phosphorylation of the Hop1 meiotic checkpoint adaptor in response to synaptonemal complex defects
Q26864595The Sum1/Ndt80 transcriptional switch and commitment to meiosis in Saccharomyces cerevisiae
Q27014855The ancient and evolving roles of cohesin in gene expression and DNA repair
Q38394869The budding yeast polo-like kinase Cdc5 regulates the Ndt80 branch of the meiotic recombination checkpoint pathway.
Q90637153The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding
Q34248122The meiotic checkpoint network: step-by-step through meiotic prophase
Q64388083The meiotic-specific Mek1 kinase in budding yeast regulates interhomolog recombination and coordinates meiotic progression with double-strand break repair
Q64386525The recombinases DMC1 and RAD51 are functionally and spatially separated during meiosis in Arabidopsis
Q33350963The recombinases Rad51 and Dmc1 play distinct roles in DNA break repair and recombination partner choice in the meiosis of Tetrahymena
Q37914029The template choice decision in meiosis: is the sister important?
Q37122881Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis
Q34469022Topoisomerase II- and condensin-dependent breakage of MEC1ATR-sensitive fragile sites occurs independently of spindle tension, anaphase, or cytokinesis.
Q33728150Trying to Avoid Your Sister
Q42363311Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex
Q27936223Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis