C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy

scientific article published on 21 January 2009

C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1681/ASN.2008040434
P932PMC publication ID2653680
P698PubMed publication ID19158354

P50authorEllen HatchQ57982426
P2093author name stringBao Lu
Steven H Sacks
Neil S Sheerin
Ziyong Tang
P2860cites workEpithelial-mesenchymal transition and its implications for fibrosisQ24302042
Complement. First of two partsQ28210663
Complement. Second of two partsQ28211878
Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosisQ28379067
Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9Q28573545
Evidence that fibroblasts derive from epithelium during tissue fibrosisQ29616581
Role of CD8(+) cells in the progression of murine adriamycin nephropathyQ32082443
Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetesQ34331403
Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of rapamycin, mycophenolate, cyclosporin, azathioprine, and methylprednisoloneQ80112123
Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in miceQ80209369
The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathyQ80375869
TGF-beta-induced EMT: mechanisms and implications for fibrotic lung diseaseQ34581113
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosisQ35087744
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosisQ35746891
Interstitial nephritis induced by protein-overload proteinuriaQ35817159
A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndromeQ35830280
Why is proteinuria an ominous biomarker of progressive kidney disease?Q35918705
Complement-mediated dysfunction of glomerular filtration barrier accelerates progressive renal injuryQ36677636
Interstitial myofibroblasts: predictors of progression in membranous nephropathyQ37202587
The transcription factors AP-1 and Ets are regulators of C3a receptor expressionQ38319410
Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: a morphometric contributionQ39718181
High levels of complement C3a receptor in the glomeruli in lupus nephritisQ40138591
Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in tubular epithelial cells of human, murine and rat kidneysQ40163511
Transdifferentiation of cultured tubular cells induced by hypoxiaQ40590913
The consequences for renal function of widening of the interstitium and changes in the tubular epithelium of the renal cortex and outer medulla in various renal diseasesQ41114296
Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell linesQ41125748
Elevated urinary excretion of the C5b-9 complex in membranous nephropathyQ41148483
Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats.Q42461036
Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient miceQ43612859
BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injuryQ44479221
Blockade of CD40-CD40 ligand protects against renal injury in chronic proteinuric renal diseaseQ44581630
Renal expression of the C3a receptor and functional responses of primary human proximal tubular epithelial cellsQ45050747
C5b-9 regulates peritubular myofibroblast accumulation in experimental focal segmental glomerulosclerosisQ45116503
Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritisQ46610901
Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injuryQ46881209
Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cellsQ46953152
The membrane attack complex, C5b-9, up regulates collagen gene expression in renal tubular epithelial cells.Q47927287
Transforming growth factor production by chemically transformed cellsQ52826927
Complement 3 is involved in changing the phenotype of human glomerular mesangial cells.Q53551146
The Brush Border of Proximal Tubules of Normal Human Kidney Activates the Alternative Pathway of the Complement System In VitroaQ58831953
A role for the C3a anaphylatoxin receptor in the effector phase of asthmaQ59068707
Measurement of SC5b-9 in urine in patients with the nephrotic syndromeQ67804910
Long-term prognosis of chronic idiopathic membranous glomerulonephritis. An analysis of 334 cases with particular regard to tubulo-interstitial changesQ69952626
Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease StudyQ71777734
Myofibroblasts, predictors of progression of mesangial IgA nephropathy?Q72396539
Membrane attack complex and membrane cofactor protein are related to tubulointerstitial inflammation in various human glomerulopathiesQ73091717
Complement membrane attack complex (C5b-9) mediates interstitial disease in experimental nephrotic syndromeQ73131858
C3a is made by proximal tubular HK-2 cells and activates them via the C3a receptorQ73205085
Complement activation products in the urine from proteinuric patientsQ73638841
The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritisQ73691361
C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritisQ77146531
C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneysQ77816447
C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusionQ79609757
Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosisQ80060245
P433issue3
P921main subjectkidney diseaseQ1054718
P304page(s)593-603
P577publication date2009-01-21
P1433published inJournal of the American Society of NephrologyQ17123893
P1476titleC3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy
P478volume20

Reverse relations

cites work (P2860)
Q34882286A complement receptor C5a antagonist regulates epithelial to mesenchymal transition and crystallin expression after lens cataract surgery in mice
Q90681133Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury
Q42386506All Things Complement
Q38238367Alport syndrome: its effects on the glomerular filtration barrier and implications for future treatment
Q38035773An update on the pathomechanisms and future therapies of Alport syndrome
Q35083760Anti-complement component C5 mAb synergizes with CTLA4Ig to inhibit alloreactive T cells and prolong cardiac allograft survival in mice.
Q35080166Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy
Q89666162Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations
Q36200905C3a and C5a promote renal ischemia-reperfusion injury
Q64076914C3a and suPAR drive versican V1 expression in tubular cells of focal segmental glomerulosclerosis
Q28545168C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway
Q37792654Cancer and the Complement Cascade
Q39097599Classical complement pathway activation in the nasal tissue of patients with chronic rhinosinusitis
Q45908661Complement 3 activates the renal renin-angiotensin system by induction of epithelial-to-mesenchymal transition of the nephrotubulus in mice.
Q48269323Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis
Q92335780Complement activation by autoantigen recognition in the growth process of benign prostatic hyperplasia
Q38348940Complement activation in progressive renal disease
Q38217273Complement as a multifaceted modulator of kidney transplant injury
Q40986583Complement in Non-Antibody-Mediated Kidney Diseases.
Q26827470Complement regulation of T cell immunity
Q26823956Complement regulation of T-cell alloimmunity
Q35151737Complement regulation of T-cell alloimmunity.
Q36913772Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis
Q27302883Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin
Q34828696Correlation analysis connects cancer subtypes
Q34365488Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis
Q84372476Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury
Q34386483Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.
Q26995453Effects of complement activation on allograft injury
Q45025014Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians
Q39759058Epidemiology of glomerulonephritis in Northern Germany
Q34786452Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia.
Q35131205Glomerular proteinuria: a complex interplay between unique players
Q53159611ISN Forefronts Symposium 2010 in Sylt, Germany: 'Induction and Resolution of Renal Inflammation'.
Q95840971Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage
Q90626648Linking innate immunity and chronic antibody-mediated allograft rejection
Q39229285Many drugs for many targets: novel treatments for complement-mediated glomerular disease
Q33711255Molecular mechanisms of chronic kidney transplant rejection via large-scale proteogenomic analysis of tissue biopsies.
Q33419651Molecules Great and Small: The Complement System
Q60313364Myofibroblasts in macular fibrosis secondary to neovascular age-related macular degeneration - the potential sources and molecular cues for their recruitment and activation
Q37439735Nitro-oleic acid protects against adriamycin-induced nephropathy in mice
Q37657039Novel aspects of complement in kidney injury
Q27004486Obstacles in haemocompatibility testing
Q91614118Pathological significance of urinary complement activation in diabetic nephropathy: A full view from the development of the disease
Q30999305Quantitative and qualitative urinary cellular patterns correlate with progression of murine glomerulonephritis
Q24657528Renal fibrosis
Q33647738Review: Complement and its regulatory proteins in kidney diseases
Q39352236Role of complement 3 in TNF-α-induced mesenchymal transition of renal tubular epithelial cells in vitro
Q92097260Role of complement 3 in the pathogenesis of hypertension
Q47560276Screening of genes involved in epithelial-mesenchymal transition and differential expression of complement-related genes induced by PAX2 in renal tubules
Q38850489Targeting the complement cascade: novel treatments coming down the pike.
Q48284080The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis.
Q99711527The Complement C3a and C3a Receptor Pathway in Kidney Diseases
Q49401359The Complement System in Dialysis: A Forgotten Story?
Q36846948The Expression Profile of Complement Components in Podocytes
Q40725046The complement receptor C5aR1 contributes to renal damage but protects the heart in angiotensin II-induced hypertension
Q88129968The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis
Q35231345The role of complement in tumor growth
Q37275159The role of the complement system in acute kidney injury
Q26851705Therapeutic regulation of complement in patients with renal disease - where is the promise?
Q61444784Upregulated long noncoding RNA LOC105375913 induces tubulointerstitial fibrosis in focal segmental glomerulosclerosis
Q57790022Urinary properdin excretion is associated with intrarenal complement activation and poor renal function

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