The role of the complement system in acute kidney injury

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The role of the complement system in acute kidney injury is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.SEMNEPHROL.2013.08.005
P932PMC publication ID3816009
P698PubMed publication ID24161039

P2093author name stringJoshua M Thurman
Brandon Renner
James W McCullough
P2860cites workRapid induction of neutrophil–endothelial adhesion by endothelial complement fixationQ59054348
C4b-binding Protein and Factor H Compensate for the Loss of Membrane-bound Complement Inhibitors to Protect Apoptotic Cells against Excessive Complement AttackQ60250539
Complement activation retards resolution of acute ischemic renal failure in the ratQ67804884
Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosisQ68856319
Initiation of the alternative complement pathway due to spontaneous hydrolysis of the thioester of C3Q70939345
Anaphylatoxin formation during hemodialysis: effects of different dialyzer membranesQ71006733
Regulated expression of complement factor B in the human kidneyQ71612640
Localization of the complement regulatory proteins in the normal human kidneyQ71651834
Ischemic acute tubular necrosis induces an extensive local cytokine response. Evidence for induction of interferon-gamma, transforming growth factor-beta 1, granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-10Q72601437
Biocompatible membranes in acute renal failure: prospective case-controlled studyQ72688835
The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cellsQ73395775
Evaluation of haemodialysis membrane biocompatibility by parallel assessment in an ex vivo model in healthy volunteersQ73718941
Pathophysiological role of T lymphocytes in renal ischemia-reperfusion injury in miceQ74247708
Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitorQ74515425
Ischemia/reperfusion-induced IFN-gamma up-regulation: involvement of IL-12 and IL-18Q77399412
Up-regulation of intracellular calcium, cyclic adenosine monophosphate and fibronectin synthesis in tubuar epithelial cells by complementQ77402483
Complement regulatory proteins in glomerular diseasesQ77650589
Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivoQ79369849
The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusionQ79370206
Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injuryQ79431461
Unrestricted C3 activation occurs in Crry-deficient kidneys and rapidly leads to chronic renal failureQ79578913
C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusionQ79609757
Intravenous immunoglobulin attenuates mesenteric ischemia-reperfusion injuryQ81245282
Acute tubular necrosis is characterized by activation of the alternative pathway of complementQ81324722
Local extravascular pool of C3 is a determinant of postischemic acute renal failureQ82436381
Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1Q24291669
Acute renal failure: definitions, diagnosis, pathogenesis, and therapyQ24563291
C5a-induced expression of P-selectin in endothelial cellsQ24633672
Expression of complement components differs between kidney allografts from living and deceased donorsQ24654702
C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunityQ24675774
Structure and biology of complement protein C3, a connecting link between innate and acquired immunityQ28202590
C3d of complement as a molecular adjuvant: bridging innate and acquired immunityQ28272810
The internal thioester and the covalent binding properties of the complement proteins C3 and C4Q28304143
Requirement and role of C5a in acute lung inflammatory injury in ratsQ28569055
Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cellsQ28610892
Initiation of the alternative pathway of complement: recognition of activators by bound C3b and assembly of the entire pathway from six isolated proteinsQ28610965
Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3Q28610996
Macrophages, dendritic cells, and kidney ischemia-reperfusion injuryQ30432565
Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectinQ33217116
The simple design of complement factor H: Looks can be deceivingQ33372312
Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndromeQ33375728
Translational mini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals.Q33378236
Complement regulators and inhibitory proteinsQ33386110
Atypical hemolytic-uremic syndromeQ33386736
Eculizumab for atypical hemolytic uremic syndrome recurrence in renal transplantation.Q33403196
Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathiesQ33403607
Complement genes strongly predict recurrence and graft outcome in adult renal transplant recipients with atypical hemolytic and uremic syndromeQ33405522
Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injuryQ33646877
Targeted and restricted complement activation on acrosome-reacted spermatozoaQ33743670
Therapeutic targeting of classical and lectin pathways of complement protects from ischemia-reperfusion-induced renal damageQ33745120
Expression of the anaphylatoxin C5a receptor in non-myeloid cellsQ33852657
Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infectionQ33925353
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidneyQ33948196
Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injuryQ34162118
Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.Q34179243
Interleukin 2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cellsQ34191473
AKI in the ICU: definition, epidemiology, risk stratification, and outcomesQ34221657
Complement-targeted therapeuticsQ34255011
Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion.Q34315819
Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3.Q34548269
Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejectionQ35088132
Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activationQ35095565
B cell subsets contribute to renal injury and renal protection after ischemia/reperfusionQ35097477
Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injuryQ35097512
The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.Q35097528
Cellular pathophysiology of ischemic acute kidney injuryQ35484725
Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodiesQ35570402
Tubulointerstitial injury induced in rats by a monoclonal antibody that inhibits function of a membrane inhibitor of complementQ35766363
Acute renal failure and sepsisQ35833149
Ischemic acute renal failure: an inflammatory disease?Q35836380
Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissueQ35885799
TLR4 activation mediates kidney ischemia/reperfusion injuryQ35987574
Innate autoimmunityQ36037749
C3a and C5a promote renal ischemia-reperfusion injuryQ36200905
Identification of the target self-antigens in reperfusion injuryQ36227933
Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complementQ36366602
The central role of the alternative complement pathway in human diseaseQ36372905
Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injuryQ36401591
Mannan binding lectin and its interaction with immunoglobulins in health and in disease.Q36524747
Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout miceQ36718295
C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathyQ37123256
Complement and renal transplantation: from donor to recipientQ37137507
Immunoglobulin and complement deposition in glomeruli of 756 subjects who had committed suicide or met with a violent deathQ37237720
The tick-over theory revisited: formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)Q37240329
A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injuryQ37434667
Dynamic control of the complement system by modulated expression of regulatory proteinsQ37797869
The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injuryQ38782859
Quantitative analysis of adenine nucleotides during the prelytic phase of cell death mediated by C5b-9.Q39250858
Structure and specificity of complement receptors.Q39764682
The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligandQ39785346
Complement activation by tubular cells is mediated by properdin bindingQ39946407
CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cellsQ40387246
Predominant role for C5b-9 in renal ischemia/reperfusion injury.Q40437461
The C5a receptor is expressed by human renal proximal tubular epithelial cellsQ40863588
Transforming growth factor-beta 1 regulates chemokine and complement production by human proximal tubular epithelial cellsQ41058011
Nontransgenic Hyperexpression of a Complement Regulator in Donor Kidney Modulates Transplant Ischemia/Reperfusion Damage, Acute Rejection, and Chronic NephropathyQ41090414
The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activityQ41923727
Specificity of the thioester-containing reactive site of human C3 and its significance to complement activationQ42828955
Inhibiting the complement system does not reduce injury in renal ischemia reperfusionQ43651985
Detection of the complement degradation product C4d in renal allografts: diagnostic and therapeutic implications.Q43830010
Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytesQ43852773
The effect of pH and nucleophiles on complement activation by human proximal tubular epithelial cellsQ43974278
Classical pathway of complement activation in normal and diseased human glomeruliQ44026716
A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in ratsQ44242757
Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in miceQ44285426
Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation.Q44317230
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assemblyQ44441855
Changes in neutrophil surface-receptor expression after stimulation with FMLP, endotoxin, interleukin-8 and activated complement compared to degranulationQ44728179
Role of Toll-like receptor 4 in endotoxin-induced acute renal failureQ44757046
Critical protection from renal ischemia reperfusion injury by CD55 and CD59.Q44788674
Renal expression of the C3a receptor and functional responses of primary human proximal tubular epithelial cellsQ45050747
Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injuryQ46480573
Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritisQ46610901
Treatment with an inhibitory monoclonal antibody to mouse factor B protects mice from induction of apoptosis and renal ischemia/reperfusion injury.Q46935293
Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils.Q48024813
Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability.Q50518455
Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology.Q50955754
Biocompatibility of hemodialysis membranes: a study in healthy subjects.Q51597719
Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional propertiesQ52735864
Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation.Q54399040
Cytolytically inactive terminal complement complex causes transendothelial migration of polymorphonuclear leukocytes in vitro and in vivoQ56943166
Mice Deficient in Complement Receptors 1 and 2 Lack a Tissue Injury-Inducing Subset of the Natural Antibody RepertoireQ57331400
Local synthesis of complement component C3 regulates acute renal transplant rejectionQ57369617
P433issue6
P304page(s)543-556
P577publication date2013-11-01
P1433published inSeminars in NephrologyQ15761561
P1476titleThe role of the complement system in acute kidney injury
P478volume33

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cites work (P2860)
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Q48055653Anti-LG3 Antibodies Aggravate Renal Ischemia-Reperfusion Injury and Long-Term Renal Allograft Dysfunction
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Q33432423Complement in disease: a defence system turning offensive
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Q34501875Complementing the inflammasome.
Q35406436Crescentic acute glomerulonephritis with isolated C3 deposition: a case report and review of literature
Q38187566Delayed kidney graft function: from mechanism to translation
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Q56341973Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease
Q55219729Epithelial C5aR1 Signaling Enhances Uropathogenic Escherichia coli Adhesion to Human Renal Tubular Epithelial Cells.
Q41106073Human Tamm-Horsfall protein, a renal specific protein, serves as a cofactor in complement 3b degradation.
Q90076810Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury
Q34484801Immunosuppressive Medications
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Q92928302Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica
Q98465643Mesenchymal Stromal Cell Uses for Acute Kidney Injury-Current Available Data and Future Perspectives: A Mini-Review
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Q38645385Potential Roles for C1 Inhibitor in Transplantation
Q91711957Trib1 Contributes to Recovery From Ischemia/Reperfusion-Induced Acute Kidney Injury by Regulating the Polarization of Renal Macrophages

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