Hypoxia induced the differentiation of Tbx18-positive epicardial cells to CoSMCs

scientific article published on 26 July 2016

Hypoxia induced the differentiation of Tbx18-positive epicardial cells to CoSMCs is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SREP30468
P932PMC publication ID4960593
P698PubMed publication ID27456656

P2093author name stringYajie Liu
Ling Wu
Qin Qin
Xiaoming Wei
Yulin Gao
Yuling Yan
Qiang She
Jianlin Du
Songbai Deng
Songlin Xiao
Xiaodong Jing
P2860cites workEssential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function.Q51948104
Inhibition of hypoxia-inducible factor activity in endothelial cells disrupts embryonic cardiovascular development.Q52038303
Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells.Q54324139
Notch signaling regulates smooth muscle differentiation of epicardium-derived cells.Q54618721
Coronary smooth muscle differentiation from proepicardial cells requires rhoA-mediated actin reorganization and p160 rho-kinase activityQ77469542
Methodologies for staining and visualisation of beta-galactosidase in mouse embryos and tissuesQ80739107
SnapShot: The epithelial-mesenchymal transitionQ83767418
Epicardial-myocardial signaling directing coronary vasculogenesisQ24303956
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locusQ24797230
Epithelial-mesenchymal transitions in development and diseaseQ27860630
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Induction of HIF-1alpha in response to hypoxia is instantaneousQ28188144
Hydroxylation of HIF-1: oxygen sensing at the molecular levelQ28276549
Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transitionQ28303161
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3Q28594589
A novel role of CDX1 in embryonic epicardial developmentQ33961259
δ-Tocotrienol oxazine derivative antagonizes mammary tumor cell compensatory response to CoCl2-induced hypoxiaQ34032720
Knockdown of β-Catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1α.Q34190465
The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cellsQ34612490
Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinomaQ34622198
Curcumin inhibits cobalt chloride-induced epithelial-to-mesenchymal transition associated with interference with TGF-β/Smad signaling in hepatocytesQ34672530
Signaling mechanisms of the epithelial-mesenchymal transitionQ35213019
Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.Q35552677
Tbx5 is required for avian and Mammalian epicardial formation and coronary vasculogenesisQ36503371
Early fetal hypoxia leads to growth restriction and myocardial thinningQ36846737
The role of hypoxia in development of the Mammalian embryoQ37671050
The Role of Snail in EMT and TumorigenesisQ37732532
The epicardium in cardiac repair: From the stem cell viewQ37799410
Mechanisms of T-box gene function in the developing heartQ37865969
Regulation of hypoxia-inducible factor-1a by reactive oxygen species: new developments in an old debateQ38302740
Reversibility of the Snail-induced epithelial-mesenchymal transition revealed by the Cre-loxP systemQ38909663
BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2.Q39022844
Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest stem cell lineQ40570886
Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established diseaseQ40666383
A myocardial lineage derives from Tbx18 epicardial cellsQ41213731
The Critical Impact of HIF-1a on Gastric Cancer BiologyQ41779542
Epicardial HIF signaling regulates vascular precursor cell invasion into the myocardiumQ41807001
Tbx18 regulates development of the epicardium and coronary vessels.Q41903030
Altered hypoxia-inducible factor-1 alpha expression levels correlate with coronary vessel anomaliesQ42096169
Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling.Q42137346
Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.Q42945812
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.Q44426540
Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cellsQ46782583
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P304page(s)30468
P577publication date2016-07-26
P1433published inScientific ReportsQ2261792
P1476titleHypoxia induced the differentiation of Tbx18-positive epicardial cells to CoSMCs
P478volume6

Reverse relations

cites work (P2860)
Q90903342Autophagy is involved in the differentiation of epicardial progenitor cells into vascular smooth muscle cells in mice
Q64271375Bone morphogenetic protein 4 promotes the differentiation of Tbx18-positive epicardial progenitor cells to pacemaker-like cells
Q52589939Hypoxia Supports Epicardial Cell Differentiation in Vascular Smooth Muscle Cells through the Activation of the TGFβ Pathway.

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