Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3

scientific journal article

Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.108.187062
P3181OpenCitations bibliographic resource ID1085718
P698PubMed publication ID19096026

P50authorMathilda MommersteegQ42853256
P2093author name stringRannar Airik
Andreas Kispert
Cornelia Wiese
Antoon F. M. Moorman
Corrie de Gier-de Vries
Karin Schuster-Gossler
Vincent M. Christoffels
Ajmal Gardiwal
Thomas Grieskamp
P433issue3
P921main subjectT-box 3Q21980211
T-box18Q21980217
P304page(s)388–397
P577publication date2009-02-13
P1433published inCirculation ResearchQ2599020
P1476titleFormation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3
P478volume104

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cites work (P2860)
Q92420779A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles
Q35878118A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node
Q33923145A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues.
Q38072446A molecular and genetic outline of cardiac morphogenesis.
Q64057867A new combination of transcription factors increases the harvesting efficiency of pacemaker‑like cells
Q35108630A novel autosomal dominant condition consisting of congenital heart defects and low atrial rhythm maps to chromosome 9q
Q64066191A rat model of complete atrioventricular block recapitulates clinical indices of bradycardia and provides a platform to test disease-modifying therapies
Q34289875Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node
Q36458816Biology of the Sinus Node and its Disease
Q64271375Bone morphogenetic protein 4 promotes the differentiation of Tbx18-positive epicardial progenitor cells to pacemaker-like cells
Q38042920Cardiac electrophysiology in mice: a matter of size
Q36371042Cell-cell junction remodeling in the heart: possible role in cardiac conduction system function and arrhythmias?
Q49923297Comparative developmental biology of the cardiac inflow tract.
Q52345226Comparison of mouse brown and white adipose‑derived stem cell differentiation into pacemaker‑like cells induced by TBX18 transduction.
Q36958996Connexin diversity in the heart: insights from transgenic mouse models
Q90577103Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1
Q30498016Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4
Q45262771Development and Function of the Cardiac Conduction System in Health and Disease
Q38987999Development of the cardiac pacemaker
Q89672951Development of the human heart
Q33968240Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overview
Q88723294Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing
Q38413376Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications
Q30544927Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.
Q55280396Dynamic Cellular Integration Drives Functional Assembly of the Heart's Pacemaker Complex.
Q35754355Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling
Q30543317Electrophysiological mapping of embryonic mouse hearts: mechanisms for developmental pacemaker switch and internodal conduction pathway
Q37777867Epicardium and Myocardium Originate From a Common Cardiogenic Precursor Pool
Q48156775Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells.
Q38548809Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models
Q26995702Gene regulatory networks in cardiac conduction system development
Q41448207Generation of murine cardiac pacemaker cell aggregates based on ES-cell-programming in combination with Myh6-promoter-selection
Q36372470Genetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole
Q38324392Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer
Q91790358Genetically Modified Porcine Mesenchymal Stem Cells by Lentiviral Tbx18 Create a Biological Pacemaker
Q37705120HCN-related channelopathies.
Q33598169HCN4 dynamically marks the first heart field and conduction system precursors
Q38546717HCN4, Sinus Bradycardia and Atrial Fibrillation
Q37125418Hypoxia induced the differentiation of Tbx18-positive epicardial cells to CoSMCs
Q45347141Identification and detection of the isolated sinus venosus from the Asian toad
Q27313717Identification and functional characterization of cardiac pacemaker cells in zebrafish
Q58582681In vitro study of the effects of reprogramming neonatal rat fibroblasts transfected with TBX18 on spontaneous beating in neonatal rat cardiomyocytes
Q41928156Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice
Q38066128Insights from cardiac development relevant to congenital defects and adult clinical anatomy
Q38274311Insights into cardiac conduction system formation provided by HCN4 expression.
Q37088714Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity
Q41136701Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia
Q35565852Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells
Q36038172Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development
Q28586231Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis
Q49257420Lineages of the Cardiac Conduction System
Q28593346Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse
Q36471561Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling
Q37865969Mechanisms of T-box gene function in the developing heart
Q46255546Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature
Q91374435Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome
Q42561001Molecular beacon-based detection and isolation of working-type cardiomyocytes derived from human pluripotent stem cells
Q38429601Morpho-functional characterization of the systemic venous pole of the reptile heart
Q24338673Mutations in TBX18 Cause Dominant Urinary Tract Malformations via Transcriptional Dysregulation of Ureter Development
Q39275029Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype
Q37819523Myocardial lineage development
Q38649331New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development
Q50923894Novel and functional variants within the TBX18 gene promoter in ventricular septal defects.
Q48172096On the Evolution of the Cardiac Pacemaker
Q38538855Pacing the Heart with Genes: Recent Progress in Biological Pacing
Q34416384Partial absence of pleuropericardial membranes in Tbx18- and Wt1-deficient mice
Q46008985Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.
Q38333728Pluripotent stem cell derived cardiovascular progenitors--a developmental perspective
Q51903805Prenatal exposure to carbon monoxide delays postnatal cardiac maturation.
Q49258743Probing the Electrophysiology of the Developing Heart.
Q38983973Programming and isolation of highly pure physiologically and pharmacologically functional sinus-nodal bodies from pluripotent stem cells
Q26823933Programming and reprogramming a human heart cell
Q58803849Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins
Q35132359RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells
Q38088192Regulation of organogenesis and stem cell properties by T-box transcription factors.
Q38456300Reprogramming the conduction system: Onward toward a biological pacemaker
Q34980766SHOX2 overexpression favors differentiation of embryonic stem cells into cardiac pacemaker cells, improving biological pacing ability
Q46425614Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by Electrophysiology.
Q43071287Setting the pace: Tbx3 and Tbx18 in cardiac conduction system development
Q37032381Shox2 influences mesenchymal stem cell fate in a co-culture model in vitro
Q35808773Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo
Q38726677Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker.
Q48106167Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate.
Q50085975Specific Cell (Re-)Programming: Approaches and Perspectives
Q37606872Specification of the cardiac conduction system by transcription factors
Q37933422T-box factors: insights into the evolutionary emergence of the complex heart
Q37341443TBX18 gene induces adipose-derived stem cells to differentiate into pacemaker-like cells in the myocardial microenvironment.
Q91797417TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome
Q42379949Tbx18 and the generation of a biological pacemaker. Are we there yet?
Q41903030Tbx18 regulates development of the epicardium and coronary vessels.
Q38851187Tbx18-dependent differentiation of brown adipose tissue-derived stem cells toward cardiac pacemaker cells
Q38067632The anatomy of the conduction system: implications for the clinical cardiologist
Q38010672The clinical and molecular relations between idiopathic preterm labor and maternal congenital heart defects
Q90086183The expanding phenotypes of cohesinopathies: one ring to rule them all!
Q26770904The formation and function of the cardiac conduction system
Q34100720The molecular genetics of congenital heart disease: a review of recent developments
Q51817893The role of Shox2 in SAN development and function.
Q35062042The role of transcription factors in atrial fibrillation
Q81446772The roles and regulation of TBX3 in development and disease.
Q44464144The sinus venosus progenitors separate and diversify from the first and second heart fields early in development
Q34612490The transcription factors Tbx18 and Wt1 control the epicardial epithelial-mesenchymal transition through bi-directional regulation of Slug in murine primary epicardial cells
Q38181536Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization.
Q36040426Transcription factor ISL1 is essential for pacemaker development and function.
Q47329000Transcription factor TBX18 promotes adult rat bone mesenchymal stem cell differentiation to biological pacemaker cells
Q58776077Transcription factor Tbx18 induces the differentiation of c-kit canine mesenchymal stem cells (cMSCs) into SAN-like pacemaker cells in a co-culture model in vitro
Q89014504Transcriptional regulation of the cardiac conduction system
Q34800053Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes
Q38695345Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice
Q90465039Unique Ca2+-Cycling Protein Abundance and Regulation Sustains Local Ca2+ Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells
Q38152991Urinary tract pacemaker cells: current knowledge and insights from nonrenal pacemaker cells provide a basis for future discovery
Q33821188Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.

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