Cardiac electrophysiology in mice: a matter of size

scientific article published on 05 September 2012

Cardiac electrophysiology in mice: a matter of size is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHYS.2012.00345
P932PMC publication ID3433738
P698PubMed publication ID22973235
P5875ResearchGate publication ID230843828

P2093author name stringSander Verheule
Sven Kaese
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Persistent activation of a swelling-activated cation current in ventricular myocytes from dogs with tachycardia-induced congestive heart failureQ39472359
Optical mapping of action potentials and calcium transients in the mouse heart.Q39585815
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2Q39696685
Digital blood flow and plasma endothelin concentration in clinically endotoxemic horsesQ39717214
Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 familiesQ40658302
Functional Roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant miceQ40730951
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Phenotypic screening for heart rate variability in the mouseQ40754804
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Electrophysiologic mechanisms of perpetuation of atrial fibrillationQ40952422
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Monophasic action potential mapping in human subjects with normal electrocardiograms: direct evidence for the genesis of the T waveQ41478760
The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts.Q41947515
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HCN3 contributes to the ventricular action potential waveform in the murine heartQ42494063
Minimal force-frequency modulation of inotropy and relaxation of in situ murine heartQ42507340
Cardiac Small Conductance Ca 2+ -Activated K + Channel Subunits Form Heteromultimers via the Coiled-Coil Domains in the C Termini of the ChannelsQ42535885
Electrophysiological characterization of murine myocardial ischemia and infarctionQ42651965
Effects of overexpression of the Na+-Ca2+ exchanger on [Ca2+]i transients in murine ventricular myocytesQ42675974
Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerabilityQ42930378
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse heartsQ42946844
A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.Q43196997
Induction of atrial tachycardia and fibrillation in the mouse heartQ43619779
Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsivenessQ43633756
Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model.Q43648748
Catheter stimulation of cardiac parasympathetic nerves in humans: a novel approach to the cardiac autonomic nervous systemQ43797639
Renal cortical and medullary blood flow during modest saline loading in humans.Q43838491
Intrinsic sinus and atrioventricular node electrophysiologic adaptations in endurance athletesQ43919820
Correlation of repolarization of ventricular monophasic action potential with ECG in the murine heartQ44027039
Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmiaQ44257722
Regional upregulation of Kv2.1-encoded current, IK,slow2, in Kv1DN mice is abolished by crossbreeding with Kv2DN miceQ44279084
Subdiaphragmatic murine electrophysiological studies: sequential determination of ventricular refractoriness and arrhythmia inductionQ44443099
Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptorsQ44480248
Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na(+)-Ca(2+) exchangerQ44572694
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Further evidence of a close anatomical relation between the oesophagus and pulmonary veins.Q53567147
Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45.Q53604390
Demonstration of Dual A-V Nodal Pathways in Patients with Paroxysmal Supraventricular TachycardiaQ53811308
Calcium content of the sarcoplasmic reticulum in isolated ventricular myocytes from patients with terminal heart failure.Q53954037
Right atrial free wall conduction velocity and degree of anisotropy in patients with stable sinus rhythm studied during open heart surgery.Q53957593
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Heterogeneous Connexin43 distribution in heart failure is associated with dispersed conduction and enhanced susceptibility to ventricular arrhythmiasQ54952185
Formation of the Venous Pole of the Heart From an Nkx2-5-Negative Precursor Population Requires Tbx18Q56000972
Reduced Cx43 Expression Triggers Increased Fibrosis Due to Enhanced Fibroblast ActivityQ58423184
Characterization of Atrial Remodeling Studied Remote from Episodes of Typical Atrial FlutterQ58865297
Pulmonary vein as an ectopic focus in digitalis-induced arrhythmiaQ59064425
Downregulation of connexin40 and increased prevalence of atrial arrhythmias in transgenic mice with cardiac-restricted overexpression of tumor necrosis factorQ59192120
Electrophysiologic Properties of the Atrioventricular Node in Pediatric PatientsQ59200856
Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mappingQ59241313
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Organisation of the mouse sinoatrial node: structure and expression of HCN channelsQ59594730
Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injuryQ60056545
Atrioventricular conduction in mammalian species: Hemodynamic and electrical scalingQ60183720
Dynamics of wavelets and their role in atrial fibrillation in the isolated sheep heartQ60183793
Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient miceQ60332323
Early Exercise Training Normalizes Myofilament Function and Attenuates Left Ventricular Pump Dysfunction in Mice With a Large Myocardial InfarctionQ62476637
Dual atrioventricular nodal pathways: a common electrophysiologic response in childrenQ66957764
Incidence and prognostic significance of intraventricular conduction abnormalities after coronary bypass surgeryQ68890613
Immunohistochemical delineation of the conduction system. I: The sinoatrial nodeQ70469133
Evidence for two components of delayed rectifier K+ current in human ventricular myocytesQ71089385
Total Excitation of the Isolated Human HeartQ71602119
Decreased heart rate variability in transgenic mice overexpressing atrial beta 1-adrenoceptorsQ71738245
Incidence and clinical relevance of the occurrence of bundle-branch block in patients treated with thrombolytic therapyQ71785114
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Paradoxical twitch potentiation after rest in cardiac muscle: increased fractional release of SR calciumQ72712946
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Slow conduction in the infarcted human heart. 'Zigzag' course of activationQ72885921
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PR interval and the response to enzyme-replacement therapy for Fabry's diseaseQ73149338
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Experimental hypothermia; respiratory and blood pH changes in relation to cardiac functionQ73349696
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Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40Q73635736
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Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3Q33906850
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Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous miceQ34092878
A quantitative study of cardiac ventricular mass in dogsQ34094206
The mathematical formulation of the problem of conduction of impulses in a network of connected excitable elements, specifically in cardiac muscle.Q34104592
Basic mechanisms of reentrant arrhythmiasQ34109839
Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in miceQ34150626
Spiral waves in two-dimensional models of ventricular muscle: formation of a stationary coreQ34168261
Inward rectifiers in the heart: an update on I(K1).Q34198377
Differential cardiac remodeling in preload versus afterloadQ34200561
Modulation of cardiac gap junction expression and arrhythmic susceptibility.Q34207091
Invasive cardiac electrophysiology in the mouse: techniques and applicationsQ34294249
Novel molecular mechanism involving alpha1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia.Q34424309
Sarcolemmal K(ATP) channels in the heart: molecular mechanisms brought to light, but physiologic consequences still in the darkQ34431594
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Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronineQ34466447
Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular nodeQ34596202
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Remodeling of early-phase repolarization: a mechanism of abnormal impulse conduction in heart failureQ34658164
Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillationQ34682855
Length of excitation wave and susceptibility to reentrant atrial arrhythmias in normal conscious dogsQ34687432
Heart rate, lifespan, and mortality riskQ34885151
Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventriclesQ34909859
Cardiac electrophysiologic and antiarrhythmic actions of a pavine alkaloid derivative, O-methyl-neocaryachine, in rat heartQ35044401
Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.Q35103181
Electrophysiological phenotyping in genetically engineered miceQ35127289
Development of the cardiac pacemaking and conduction systemQ35136820
Oxidized CaMKII causes cardiac sinus node dysfunction in mice.Q35572691
Developmental anatomy of the heart: a tale of mice and man.Q35581652
Arrhythmogenic effect of sympathetic histamine in mouse hearts subjected to acute ischemiaQ35719014
Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout miceQ35737061
Studying cardiac arrhythmias in the mouse--a reasonable model for probing mechanisms?Q35761984
Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart.Q35768779
Remodeling of the peripheral cardiac conduction system in response to pressure overloadQ35900985
Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humansQ36042506
Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoproteinQ36072681
QTc prolongation is associated with impaired right ventricular function and predicts mortality in pulmonary hypertensionQ36075721
Separation of early afterdepolarizations from arrhythmogenic substrate in the isolated perfused hypokalaemic murine heart through modifiers of calcium homeostasisQ36088707
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in miceQ36116647
Na(+)--Ca2+ exchange in the regulation of cardiac excitation-contraction couplingQ36151260
Effects of Na+-Ca2+ exchange expression on excitation-contraction coupling in genetically modified miceQ36225124
Of circles and spirals: bridging the gap between the leading circle and spiral wave concepts of cardiac reentryQ36231056
Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1.Q36249250
Mechanisms of atrial fibrillation: lessons from animal models.Q36272316
Interleukin 6 knockout prevents angiotensin II hypertension: role of renal vasoconstriction and janus kinase 2/signal transducer and activator of transcription 3 activationQ36406495
Calcium signaling in transgenic mice overexpressing cardiac Na(+)-Ca2+ exchangerQ36411808
Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytesQ36420431
Propagation of pacemaker activityQ36585110
Triggered firing and atrial fibrillation in transgenic mice with selective atrial fibrosis induced by overexpression of TGF-β1.Q36671389
Universal scaling law of electrical turbulence in the mammalian heartQ36693417
Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failureQ36737403
Visualization and functional characterization of the developing murine cardiac conduction systemQ36778773
Regional, age-dependent, and genotype-dependent differences in ventricular action potential duration and activation time in 410 Langendorff-perfused mouse heartsQ44767110
Effects of Na(+)/Ca(2+)-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes.Q44796804
Effects of mechanical uncouplers, diacetyl monoxime, and cytochalasin-D on the electrophysiology of perfused mouse heartsQ44932400
Functional properties of K+ currents in adult mouse ventricular myocytesQ44991716
"Early" class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goatQ45057043
Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic miceQ45166532
Is the 1975 Reference Man still a suitable reference?Q45396245
Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in miceQ45546298
Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization?Q45919942
Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant mice.Q45960359
Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes.Q45990555
Development and characterization of a mouse in vitro model of ischaemia-induced ventricular fibrillation.Q46116646
In vivo effect of a dominant negative Kv4.2 loss-of-function mutation eliminating I(to,f) on atrial refractoriness and atrial fibrillation in miceQ46162420
Cardiovascular indexes in the mouse at rest and with exercise: new tools to study models of cardiac diseaseQ46183015
Function and structure of the mouse sinus node: nothing you can see that isn't shownQ46372156
Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atriumQ46453506
Heart weight as a function of body weight in mammalsQ46626959
Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injuryQ46716871
Cardiac alternans in embryonic mouse ventriclesQ46748619
Heart weight and heart weight/body weight coefficient in malnourished adultsQ47185705
Organ weight in 684 adult autopsies: new tables for a Caucasoid populationQ47210091
Differences in left ventricular long-axis function from mice to humans follow allometric scaling to ventricular size.Q47375857
New insights into the atrial electrophysiology of rodents using a novel modality: the miniature-bipolar hook electrodeQ47428141
Spontaneous and inducible ventricular arrhythmias after myocardial infarction in miceQ47773542
Involvement of IsK-associated K+ channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndromeQ47817391
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.Q47866453
Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conductionQ47954061
Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouseQ48220117
Mouse strain determines the outcome of wound healing after myocardial infarctionQ48560772
Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardiumQ48749195
An equine model of chronic atrial fibrillation: methodologyQ49040219
Blood pressure and heart rate variabilities in normotensive and hypertensive human beingsQ49108735
Myocardial ischemia and reperfusion: a murine model.Q50755945
Transgenic upregulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability.Q50797858
Incidence and prognostic value of electrocardiographic abnormalities after heart transplantation.Q50864472
Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice.Q50866066
Measurement of heart rate and Q-T interval in the conscious mouse.Q50898283
Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts.Q51015768
Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43.Q51033472
Atrioventricular nodal reverse facilitation in connexin40-deficient mice.Q51329451
Short-term and long-term blood pressure and heart rate variability in the mouse.Q51421834
Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation.Q51469223
Murine cardiac function: a cautionary tail.Q51528456
Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide.Q51564122
Maximum heart rate of soricine shrews: correlation with contractile properties and myosin compositionQ51692020
Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice.Q51795127
Molecular analysis of patterning of conduction tissues in the developing human heart.Q51867176
Developmental origin, growth, and three-dimensional architecture of the atrioventricular conduction axis of the mouse heart.Q51903075
Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system.Q51988770
Embryonic conduction tissue: a spatial correlation with adult arrhythmogenic areas.Q52001186
Postnatal development of atrial repolarization in the mouse.Q52087592
Electrical remodeling due to atrial fibrillation in chronically instrumented conscious goats: roles of neurohumoral changes, ischemia, atrial stretch, and high rate of electrical activationQ73937010
A spontaneously active focus drives a model atrial sheet more easily than a model ventricular sheetQ74103849
Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conductionQ74292476
Electrophysiological features of the mouse sinoatrial node in relation to connexin distributionQ74513784
Effect of endurance training on cardiac morphology in Alaskan sled dogsQ77369261
Na+-Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+-Ca2+ exchangerQ77400588
Monophasic action potential recordings from intact mouse heart: validation, regional heterogeneity, and relation to refractorinessQ77402063
A double-blind placebo-controlled evaluation of the human electrophysiologic effects of zatebradine, a sinus node inhibitorQ77442824
Importance of refractoriness heterogeneity in the enhanced vulnerability to atrial fibrillation induction caused by tachycardia-induced atrial electrical remodelingQ77555009
Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytesQ77648912
Differential effects of cytochalasin D and 2,3 butanedione monoxime on isometric twitch force and transmembrane action potential in isolated ventricular muscle: implications for optical measurements of cardiac repolarizationQ77738218
Atrial electrophysiologic remodeling: another vicious circle?Q77738235
Anisotropic conduction properties in canine atria analyzed by high-resolution optical mapping: preferential direction of conduction block changes from longitudinal to transverse with increasing ageQ78019752
Reentry and fibrillation in the mouse heart. A challenge to the critical mass hypothesisQ78031811
Cardiac Na/Ca exchange function in rabbit, mouse and man: what's the difference?Q78049992
In-vivo electrophysiological study in mice with chronic anterior myocardial infarctionQ78050736
Induction of atrial fibrillation in mice by rapid transesophageal atrial pacingQ78413988
Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conductionQ79313815
In vivo temporal and spatial distribution of depolarization and repolarization and the illusive murine T waveQ79317566
Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QTQ79365505
Atrioventricular nodal reentrant tachycardia with multiple discontinuities in the atrioventricular node conduction curve: immediate success rates of radiofrequency ablation and long-term clinical follow-up results as compared to patients with singleQ80064180
Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitutionQ80237119
The effect of vernakalant (RSD1235), an investigational antiarrhythmic agent, on atrial electrophysiology in humansQ80711628
Postnatal development has a marked effect on ventricular repolarization in miceQ80736288
Overexpression of junctate induces cardiac hypertrophy and arrhythmia via altered calcium handlingQ80915724
Mechanism for atrial tachyarrhythmia in chronic volume overload-induced dilated atriaQ80951729
Discontinuous conduction in mouse bundle branches is caused by bundle-branch architectureQ81307969
Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-{alpha}Q81795819
Intracellular sodium increase and susceptibility to ischaemia in hearts from type 2 diabetic db/db miceQ82315525
Rotigaptide (ZP123) reverts established atrial conduction velocity slowingQ82795780
Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heartQ83154234
Arrhythmia phenotype in mouse models of human long QTQ83196257
Abnormal atrioventricular node conduction and atrioventricular nodal reentrant tachycardia in patients older versus younger than 65 years of ageQ83402848
Left atrial remodeling in patients with atrial septal defectsQ83988595
Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heartQ84980492
Fibrillatory conduction in the atrial free walls of goats in persistent and permanent atrial fibrillationQ85179948
P921main subjectelectrophysiologyQ1154774
P304page(s)345
P577publication date2012-09-05
P1433published inFrontiers in PhysiologyQ2434141
P1476titleCardiac electrophysiology in mice: a matter of size
P478volume3

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